Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02604199
2014-004145-27
Details
2019-04-16
Interventional
258 
Entecavir Histamine Antag… Histamine H1 An… Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
Company decision to discontinue trial
The ARC-520 Injection development program was terminated early for regulatory and business reasons secondary to findings occurring in a non-clinical toxicology study. Program termination was not due to safety findings in humans.
NCT01789047
Details
2019-04-16
Interventional
242 
Amantadine Topiramate
Dyskinesia, Dru… Dyskinesias Parkinson Disea… Drug Induced Dy… Idiopathic Park…
Sponsor withdrew support
-
NCT01739400
Details
2019-04-16
Interventional
3217 
Macitentan
Eisenmenger Com… Pulmonary Arter…
Primary endpoint of parent study AC-055-305/MAESTRO (NCT01743001) not met.
The MAESTRO parent study AC-055-305 (NCT01743001) did not meet its primary endpoint. The sponsor decided to prematurely terminate this OL study on January 12th 2018.
NCT01072643
Details
2019-04-16
Interventional
2/34 
Dexmedetomidine
Hypertension Hypertension, P… Pulmonary Hyper…
Study was terminated due to increased PVR in one subject from T0-T1 reaching the level of a predetermined stopping rule
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NCT00562055
Details
2019-04-16
Interventional
20 
Atomoxetine Hyd… Reboxetine
Attention Defic… Hyperkinesis Attention Defic…
This study was withdrawn due to business reasons.
-
NCT00403052
Details
2019-04-16
Interventional
114 
1018 oligonucle…
Colorectal Neop…
Administrative reasons
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NCT00387738
Details
2019-04-16
Interventional
2738 
Histamine
Rhinitis Rhinitis, Aller… Rhinitis, Aller…
Interim data indicated that subjects exhibited no meaningful allergic disease during the first ragweed season, making it impossible to measure treatment effect.
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NCT02577029
2015-005499-46
Details
2019-04-12
Interventional
279 
Entecavir Histamine Antag… Histamine H1 An… Interferon alph… Interferon-alph… Interferons Peginterferon a… Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis D
Company decision to discontinue trial
The ARC-520 Injection development program was terminated early for regulatory and business reasons secondary to findings occurring in a non-clinical toxicology study. Program termination was not due to safety findings in humans.
NCT02556593
Details
2019-04-12
Interventional
212 
Erlotinib Hydro…
Brain Neoplasms Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
-
-
NCT02518971
Details
2019-04-12
Interventional
3176 
Tamsulosin
Urinary Retenti… Postoperative U…
interim analysis revealed no significant difference between study groups & increased sample size required to gain significance.
-
NCT01287741
2010-024194-39
Details
2019-04-12
Interventional
31418 
Cyclophosphamid… Doxorubicin Obinutuzumab Prednisone Rituximab Vincristine
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
The study was closed by the Sponsor according to the protocol-specified minimum post-treatment follow-up period of 3 years.
-
NCT02910882
Details
2019-04-11
Interventional
24 
Gemcitabine
Adenocarcinoma Pancreatic Aden…
Safety
-
NCT03553615
Details
2019-04-10
Interventional
20 
Ivermectin
Dermatitis Dermatitis, Ato… Eczema Atopic Dermatit…
Limited clinical capacity
-
NCT02706015
Details
2019-04-10
Interventional
30 
Caffeine Dihydroergotami… Dipyrone
Headache Migraine Disord… Migraine Headac…
Strategic reasons of the company
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NCT02582996
Details
2019-04-10
Interventional
3-
Acetaminophen Caffeine Dihydroergotami… Metoclopramide
Migraine Disord… Migraine
Strategic reasons of the company
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NCT01856101
2012-004123-20
Details
2019-04-10
Interventional
222 
Dactolisib MTOR Inhibitors
Carcinoma Carcinoma, Tran… Carcinoma Trans…
Novartis decided to stop the marketing of BEZ235
-
NCT01213329
Details
2019-04-10
Interventional
452 
Alemtuzumab
Kidney Transpla…
-
Processing of blood samples was inconsistent and lab results were questionable. Research blood specimens were in addition to Standard of Care (SOC) required blood. Most research visits were planned at the same time as SOC visits.
NCT03038009
Details
2019-04-09
Interventional
40 
Pantoprazole
Peptic Ulcer Stomach Ulcer Ulcer Gastric Ulcer I… Proton Pump Inh… Ulcer of the Ga…
A new registration has been submitted due to a redesign of the study protocol.
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NCT00923390
NCT00870389
Details
2019-04-09
Interventional
15 
Aldesleukin Cyclophosphamid… Fludarabine
Carcinoma, Rena… Kidney Neoplasm… Kidney Cancer Renal Cancer
-
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NCT03114280
Details
2019-04-08
Interventional
1/20 
Carboplatin
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
MSD would not able to support the study's continuation after protocol modifications required by ANSM through dose de-escalation of pembrolizumab
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