Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01662895
Details
2019-06-12
Interventional
242 
Deferoxamine
Cerebral Hemorr… Hemorrhage Intracerebral H…
By DSMB on October 18, 2013 due to increased incidence of ARDS. See modified protocol [NCT02175225
The study was terminated prematurely, and only 42 subjects were enrolled. As a result, any formal evaluation of these outcomes would be under-powered. Only descriptive statistics are provided.
NCT00731874
Details
2019-06-12
Interventional
434 
Tacrolimus
Immunosuppressi…
A higher rate of late rejection was seen in the low tacrolimus arm.
The population reported is small because the study was stopped early due to the increase in late antibody mediated rejection (occurring after month 15) that was seen in Arm 2 (target tacrolimus trough 3 to 5 ng/mL).
NCT03697239
Details
2019-06-11
Interventional
1/20 
Albumin-Bound P… Ascorbic Acid Gemcitabine Paclitaxel
Adenocarcinoma Pancreatic Neop… Metastatic Panc… Pancreas Cancer Pancreatic Aden… Pancreatic Canc… Pancreatic Duct… Pancreatic Meta…
FDA indicated the same study could not be conducted under multiple INDs
-
NCT02147834
Details
2019-06-11
Interventional
25 
Ranolazine
Angina
due to futility
-
NCT02769065
Details
2019-06-10
Interventional
1179 
Donepezil
Alzheimer Disea… Cognitive Dysfu… Healthy Volunte…
Terminated prematurely as data from cohort no longer needed due to indication change.
-
NCT00968968
Details
2019-06-10
Interventional
337 
Lapatinib Trastuzumab
Cancer
-
This study was closed to further enrollment since the enrollment rate would not allow the study to complete enrollment within an acceptable timeframe.
NCT03299387
Details
2019-06-06
Interventional
40 
Gentamicins Nitrofurantoin
Communicable Di… Infections Urinary Tract I…
Study never recruited
-
NCT01920477
Details
2019-06-06
Interventional
335 
Ofatumumab
Pemphigus Pemphigus Vulga…
Novartis has acquired the rights to ofatumumab and terminated the OPV116910 and OPV117059 studies. This decision is not linked to any safety consideration.
-
NCT03571594
Details
2019-06-05
Interventional
176 
Octreotide
Acromegaly
The study met a pre-defined protocol study stopping criteria
-
NCT03468543
2017-000982-61
Details
2019-06-05
Interventional
13 
Memantine
Gastric Retenti… Healthy
Per protocol stopping rules
The trial was prematurely ended after the dosing of three subjects.
NCT03099161
Details
2019-06-05
Interventional
110 
Pembrolizumab
Neoplasm
The data did not support study endpoints
This study was terminated early because the data did not support the study endpoints.
NCT02398500
2014-005214-37
Details
2019-06-05
Interventional
1/225 
Ranibizumab
Macular Degener… Age-related Mac…
Management decision
-
NCT01862263
Details
2019-06-05
Interventional
4191 
Vildagliptin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
-
-
NCT01582152
Details
2019-06-05
Interventional
1/212 
Bevacizumab
Brain Neoplasms Central Nervous… Glioblastoma Neoplasms Nervous System …
Phase 2 part of the trial will no longer continue since the protocol competes with another TPI287 protocol in outside institution supported by the sponsor.
-
NCT00524173
Details
2019-06-05
Interventional
235 
Emtricitabine Tenofovir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
-
-
NCT02585479
Details
2019-06-04
Interventional
2/30 
Ethiodized Oil Gelatin Sponge,… Oxaliplatin Pirarubicin
Carcinoma Carcinoma, Hepa… Hepatocellular …
It doesn't meet the requirements of randomized trials
-
NCT02534337
Details
2019-06-04
Interventional
2/30 
Fluorouracil Gemcitabine Leucovorin Oxaliplatin
Carcinoma Carcinoma, Hepa… Hepatocellular …
It doesn't meet the requirements of randomized trials
-
NCT02527772
Details
2019-06-04
Interventional
2/3
[2 Refs]
0 
Doxorubicin Fluorouracil Gemcitabine Leucovorin Liposomal doxor… Oxaliplatin
Carcinoma Carcinoma, Hepa… Hepatocellular …
It doesn't meet the requirements of randomized trials
-
NCT02490774
2013-003980-74
Details
2019-06-04
Interventional
2174 
Levonorgestrel
Contraception
-
-
NCT01748240
2012-001401-25
Details
2019-06-04
Interventional
221 
Azacitidine Vorinostat
Myelodysplastic… Preleukemia Syndrome Myelodysplastic…
inefficiency
-