Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04361214
Details
2024-02-07
Interventional
111 
Leflunomide
COVID-19
Terminated by PI
-
NCT04128696
2019-002263-99
Details
2024-02-07
Interventional
2/3315 
Pembrolizumab
Carcinoma Carcinoma, Squa… Head and Neck N… Squamous Cell C… Neoplasms, Head…
The trial was stopped by the sponsor based on assessment of the clinical data
Data are reported following the interim analysis decision to stop further accrual into the study and discontinue feladilimab/placebo. The study primary completion analysis results should be interpreted with consideration of the immature data
NCT04037254
Details
2024-02-07
Interventional
2-
Follicle Stimul… Hormones Niraparib Prolactin Relea…
Prostatic Neopl… Prostate Adenoc… Stage IIC Prost… Stage III Prost… Stage IIIA Pros… Stage IIIB Pros… Stage IIIC Pros… Stage IVA Prost…
Protocol specified toxicity analysis
-
NCT03974854
Details
2024-02-07
Interventional
225 
Capecitabine Gemcitabine Irinotecan
Adenocarcinoma Metastatic Panc…
sponsor decision
-
NCT05470491
Details
2024-02-06
Interventional
1/2-
Maraviroc Plerixafor
Hematologic Neo… Neoplasms HIV Hematologic Mal…
On administrative hold for interim data analysis.
-
NCT05386472
Details
2024-02-06
Interventional
1-
Nirmatrelvir Ritonavir
COVID-19
Recruitment was paused to allow time for further pharmacokinetic modelling and simulation work to be performed to determine further dose regimens and PK blood sampling. No safety concerns have been observed in participants enrolled to date.
-
NCT04323436
2019-003097-11
Details
2024-02-06
Interventional
231 
Spartalizumab
Carcinoma, Non-…
Study termination based on sponsor decision due to lack of tolerability observed with capmatinib and spartalizumab combination treatment when compared to data from capmatinib single agent studies
-
NCT03722966
Details
2024-02-06
Interventional
2
[1 Refs]
34 
Nicotine Varenicline
Smoking Cessati…
Following the Chantix recall, Pfizer stopped providing medication for the study and and new study enrollments were discontinued.
The study was discontinued early due to the recall of varenicline.
NCT03684694
2018-002625-38
Details
2024-02-06
Interventional
1/2136 
Ibrutinib Loncastuximab t…
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Mantl… Diffuse Large B… Mantle Cell Lym…
Administrative decision
-
NCT03258723
Details
2024-02-06
Interventional
4114 
Metformin
Diabetes Mellit… Diabetes
COVID-19 led to changes in study design and an early end to data collection.
-
NCT00550862
Details
2024-02-06
Interventional
2165 
Ursodeoxycholic…
Fibrosis Liver Cirrhosis Liver Cirrhosis…
Study stopped by sponsor due to administrative reasons
-
NCT05321251
Details
2024-02-05
Interventional
2/3
[1 Refs]
0 
Insulin
Keratitis Neurotrophic Ke…
Study never commenced due to logistical issues.
-
NCT04984278
2020-003271-18
Details
2024-02-05
Interventional
356 
Nabiximols
Multiple Sclero… Muscle Spastici… Sclerosis Spasticity With…
The study was terminated based on a business decision by the Sponsor.
-
NCT04596995
2019-000883-40
Details
2024-02-05
Interventional
343 
Rozanolixizumab
Purpura, Thromb… Thrombocytopeni… Primary Immune …
Strategic Business Decision; Not a safety decision
-
NCT04071236
Details
2024-02-05
Interventional
1/2-
Antibodies, Mon… Avelumab Peposertib Radium Ra 223 d…
Carcinoma Neoplasms Prostatic Neopl… Castration-Resi… Metastatic Mali… Metastatic Pros… Stage IV Prosta…
End of Initial Phase of Multi-phase protocol
-
NCT05351554
Details
2024-02-02
Interventional
21 
Antibodies, Mon… Prednisone
Sarcoidosis Sarcoidosis, Ca…
Sponsor business decision not related to safety
-
NCT04840615
Details
2024-02-02
Interventional
12 
Acetaminophen Dexamethasone Diphenhydramine Famotidine Ipilimumab LMB-100 Promethazine
Mesothelioma Mesothelioma, M…
Study was closed early due to slow accrual.
-
NCT04676061
Details
2024-02-02
Interventional
451 
Norethindrone Norethindrone A…
Hemorrhage Metrorrhagia Uterine Hemorrh… Birth Control Breakthrough Bl… Contraception Implant Uterine Bleedin…
It was in the best interest of the investigator to terminate the study earlier than anticipated.
-
NCT04418167
Details
2024-02-02
Interventional
171 
Dabrafenib
Neoplasms Solid Tumors
Sponsor decision
-
NCT04380545
Details
2024-02-02
Interventional
1/2-
Fluorouracil Interferon alph… Interferon-alph… Interferons Nivolumab
Carcinoma Carcinoma, Hepa… Stage III Hepat… Stage IIIA Hepa… Stage IIIB Hepa… Stage IV Hepato… Stage IVA Hepat… Stage IVB Hepat… Unresectable Fi…
PI Request
-