Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02736578
Details
2019-06-25
Interventional
2
[1 Refs]
8 
Cetuximab
Pancreatic Aden…
Logistics
-
NCT00748189
Details
2019-06-25
Interventional
3447 
Chlorambucil Ofatumumab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Leukaemia, Lymp…
Majority of patients (62%) had been treated with next line therapies, including new highly effective therapies confounding the interpretation of the OS results.
-
NCT00448864
Details
2019-06-25
Interventional
275 
Ecallantide
Blood Loss, Sur… Hemorrhage
Experience gained from this study is sufficient to design and facilitate the follow-on study.
-
NCT02762331
Details
2019-06-24
Interventional
16 
Ascorbic Acid
Atrial Fibrilla… Heart Valve Dis… Complications D… Disorder of Vit… Heart Valve Dis…
Therapy shown effective by larger studies
-
NCT01987375
Details
2019-06-24
Interventional
11 
Cetuximab
Head and Neck N… Head and Neck C…
logistics
-
NCT03642145
Details
2019-06-21
Interventional
30 
Deflazacort
Muscular Dystro… Muscular Dystro… Duchenne Muscul…
Study is no longer necessary given the safety and efficacy of emflaza in this age range has already been established after review of already available data.
-
NCT02494102
Details
2019-06-20
Interventional
4105 
Modafinil
Apnea Delayed Emergen… Sleep Apnea Syn… Sleep Apnea, Ob… Delayed Emergen… Obstructive Sle…
-
Trial terminated for statistical futility on scheduled interim analysis
NCT02524106
Details
2019-06-19
Interventional
311 
Bococizumab
Cardiovascular … Dyslipidemias Cardiovascular … Dyslipidemia
Industry won't be moving forward with production of bococizumab
-
NCT01247922
2010-023478-38
Details
2019-06-19
Interventional
24 
Erlotinib Hydro…
Ependymoma
In a pre-planned interim analysis, OSI-774-205 met futility for efficacy with no safety concerns. As a result, the companion trial, OSI-774-206 has been stopped
Company makes no warranties or representations of any kind as to the posting, expressed or implied, including warranties of merchantability and fitness for a particular purpose, and shall not be liable for any damages.
NCT01176318
Details
2019-06-19
Interventional
40 
Erdosteine
Lung Diseases Lung Diseases, … Pulmonary Disea… Chronic Obstruc…
grant was withdrawn no financial support to conduct the study.
-
NCT01032070
2009-016836-11
Details
2019-06-19
Interventional
225 
Erlotinib Hydro… Etoposide
Ependymoma Recurrence Recurrent or Re…
In a pre-planned interim analysis, OSI-774-205 met futility for efficacy with no safety concerns. As a result, it has been stopped.
Company makes no warranties or representations of any kind as to the posting, expressed or implied, including warranties of merchantability and fitness for a particular purpose, and shall not be liable for any damages.
NCT02160041
Details
2019-06-18
Interventional
284 
Infigratinib
Hematologic Neo… Neoplasms Hematologic Mal… Solid Tumor
-
-
NCT01853228
2013-000390-70
Details
2019-06-17
Interventional
1/217 
Cytarabine Decitabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
EMA/PDCO acknowledged that available results from this study do not support further clinical studies in relapsed/refractory AML paediatric patients.
The Sponsor terminated the study earlier than planned due to lack of efficacy with 8 evaluable participants in Phase 2 with no clinically meaningful anti-leukemic activity.
NCT02918266
Details
2019-06-14
Interventional
118 
Butylscopolammo… Donepezil Scopolamine
Cognitive Dysfu… Healthy Volunte…
Terminated prematurely due to indication change.
-
NCT02744833
Details
2019-06-14
Interventional
1/22 
Enoxaparin Enoxaparin sodi…
Thrombosis Venous Thrombos… Deep Venous Thr…
The trial was funded in part by a grant; the trial closed when the grant ended.
-
NCT02431260
Details
2019-06-14
Interventional
1/269 
INCB054329
Hematologic Neo… Neoplasms Solid Tumors an…
As of 31 JAN 2018, the study was terminated by the sponsor due to PK variability.
-
NCT03348904
Details
2019-06-13
Interventional
32 
Carboplatin Gemcitabine Nivolumab Paclitaxel Pemetrexed
Carcinoma, Non-… Lung Neoplasms Lung Cancer
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention.
-
NCT02608931
Details
2019-06-13
Interventional
20 
Dronabinol
Autonomic Nervo… Dysautonomia, F… Nausea Primary Dysauto… Vomiting Familial Dysaut…
Unable to begin study with drug provider
-
NCT02206932
Details
2019-06-13
Interventional
40 
Simeprevir Sofosbuvir
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… HIV CDC Categor…
never opened
-
NCT03715023
2018-001667-24
Details
2019-06-12
Interventional
25 
PC-786
Communicable Di… Infections Respiratory Syn…
Practical issues that could not be resolved resulting in recruitment difficulties at sites.
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