Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02663674
Details
2019-07-05
Interventional
472 
Fluconazole
Coccidioidomyco… Coccidiosis Pneumonia
Study terminated due to lack of feasibility of study design.
The study terminated early due to low enrollment rates. When the study was stopped, 72 of a planned 1000 participants were enrolled and randomized; therefore, formal comparisons of the endpoints are not included.
NCT02630186
Details
2019-07-05
Interventional
1/23 
Atezolizumab
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
The study terminated before Phase 1 was completed. This study was reprioritized within the rociletinib development program.
This study was terminated early which lead to small number of subjects analyzed. The study did not reach the target number of participants needed to achieve target power and statistically reliable results.
NCT02496715
Details
2019-07-05
Interventional
30 
Fluticasone Salmeterol Xina… Xhance
Asthma
Development terminated.
-
NCT02435303
Details
2019-07-05
Interventional
2/32 
Sildenafil Citr…
Hypertension Hypertension, P… Diseases of Mit…
Number of candidates for this study is expected to be too small.
-
NCT02065336
Details
2019-07-05
Interventional
258 
Chlorpheniramin… Entecavir
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch…
Company decision to discontinue trial
The ARC-520 Injection development program was terminated early for regulatory and business reasons secondary to findings occurring in a non-clinical toxicology study. Program termination was not due to safety findings in humans.
NCT01760980
Details
2019-07-05
Interventional
10 
Exemestane
Healthy
Development halted by management
-
NCT01601093
Details
2019-07-05
Interventional
2-
Cefoperazone Sulbactam Sulperazone
Communicable Di… Infections Respiratory Tra… Urinary Tract I…
other project got priority
-
NCT01912872
Details
2019-07-02
Interventional
4112 
Budesonide Formoterol Fuma… Omalizumab
Asthma Severe IgE-medi…
Termination was due to identified errors in data management handling after an internal audit by the sponsor performed by third party.
-
NCT00759642
Details
2019-07-01
Interventional
233 
Lapatinib
Breast Neoplasm… Metastatic Brea…
IRB decision
-
NCT02696954
Details
2019-06-28
Interventional
1/217 
Amodiaquine Artemether Artemether, Lum… Lumefantrine Primaquine
Drug Combinatio… Healthy Pharmacokinetic
-
-
NCT02932488
Details
2019-06-27
Interventional
117 
Sumatriptan
Healthy Volunte…
Pilot study with sumatriptan found no significant changes in the primary outcome parameter (change in CBF)
-
NCT01632566
Details
2019-06-27
Interventional
139 
Celecoxib LY3031207 Simvastatin
Healthy Volunte…
Elevation of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in some participants.
Lilly voluntarily discontinued dosing of LY3031207 for all participants in LBCB because of early discontinuation criteria being met. Data for some endpoints (including blood pressure and Japanese comparison) were incomplete for the planned analyses.
NCT01111188
Details
2019-06-27
Interventional
120 
Bortezomib Palbociclib
Lymphoma Lymphoma, Mantl… Mantle Cell Lym…
-
-
NCT00148616
Details
2019-06-27
Interventional
313 
Memantine
Cognitive Dysfu… Schizophrenia Chronic Schizop…
-
-
NCT00148590
Details
2019-06-27
Interventional
324 
Memantine
Cognitive Dysfu… Schizophrenia
-
-
NCT02759315
Details
2019-06-26
Interventional
2
[1 Refs]
160 
Ruzasvir Uprifosbuvir
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch…
The study was terminated based on review of Phase 2 efficacy data
-
NCT02367352
Details
2019-06-26
Interventional
19 
Paclitaxel
Small Cell Lung… Advanced Solid … Ovarian Cancer Small Cell Lung…
Sponsor's decision
-
NCT02343575
Details
2019-06-26
Interventional
43 
Haloperidol Haloperidol dec… Valproic Acid
Delirium Hyperkinesis Psychomotor Agi… Hyperactive Del… Mixed Delirium
We did not recruit the research assistant and terminated the study
The study terminated early and did not meet its planned sample size of 30 participants, leading to a small number of subjects analyzed.
NCT01892345
Details
2019-06-26
Interventional
3
[1 Refs]
143 
Eculizumab
Neuromyelitis O… Neuromyelitis O…
-
After rigorous review of blinded study data, the Sponsor terminated the study at 23 adjudicated events, not the protocol-specified 24. This was not driven by safety or efficacy concerns, but rather by uncertainty in estimating final event occurrence.
NCT02966730
Details
2019-06-25
Interventional
12 
Ibrutinib
Lymphoma Lymphoma, Folli… Follicular Lymp… Follicular Lymp… Follicular Lymp… Follicular Lymp…
Lack of accrual
-