Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00687674
Details
2019-08-20
Interventional
113 
Dexamethasone Lenalidomide Sorafenib
Multiple Myelom… Neoplasms, Plas… Plasmacytoma Multiple Myelom…
Due to study design (and toxicity), this trial closed to accrual prior to opening the phase II portion.
-
NCT00397878
Details
2019-08-20
Interventional
210 
Saracatinib
Adenocarcinoma Colonic Neoplas… Rectal Neoplasm… Recurrence Adenocarcinoma … Adenocarcinoma … Recurrent Colon… Recurrent Recta… Stage IV Colon … Stage IV Rectal…
The study was terminated after all enrolled participants progressed.
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NCT03879278
Details
2019-08-19
Interventional
18 
Immunoglobulin … Immunoglobulins
Amyloidosis
Mild infusion reactions were observed in two healthy volunteers.
-
NCT03242434
Details
2019-08-19
Interventional
118 
Lactulose Mannitol
Burns
This trial was supporting the development of an asset which was terminated, thus the data from the study were no longer required.
-
NCT01124227
2009-017711-15
Details
2019-08-16
Interventional
326 
Icodextrin
Heart Failure Congestive Hear…
Due to very specific inclusion criteria the anticipated number of patients was not reached. Inclusion stopped at N=26, allowing for analyzing primary outcomes.
-
NCT00729807
Details
2019-08-16
Interventional
26 
Pentamidine
Melanoma Melanoma (Skin)
Study was closed at the suggestion of DSMB prior to obtaining target enrollment
Unable to reach the target number of participants needed before study was closed at the suggestion of DSMB
NCT02686710
Details
2019-08-15
Interventional
410 
Propofol Sevoflurane
Glycogen Syntha…
-
-
NCT02636803
Details
2019-08-15
Interventional
20 
Albendazole Oxfendazole
Helminthiasis Trichuriasis
not going to be conducted
-
NCT02394418
Details
2019-08-15
Interventional
40 
Dexmedetomidine Propofol Sevoflurane
Delirium Neuroinflammato…
for technical reasons
-
NCT03480867
Details
2019-08-14
Interventional
10 
Temozolomide
Glioblastoma Glioblastoma Mu…
competing study was opened by the surgeon after this trial was opened
-
NCT03431675
Details
2019-08-14
Interventional
40 
Ciprofloxacin
Meningitis Meningitis, Men…
No epidemic of Men C in 2019
-
NCT02949492
Details
2019-08-14
Interventional
46 
Interleukin-2
Liver Diseases Transplantation
Safety concerns
-
NCT02337478
Details
2019-08-14
Interventional
25 
Vincristine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Recurrent Adult…
The study was stopped early due to futility.
-
NCT02322281
Details
2019-08-14
Interventional
3149 
Docetaxel Gemcitabine Paclitaxel Pemetrexed
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Sponsor discontinued development of CO-1686 for NSCLC
Due to early study termination, only 149 of 600 planned patients were randomized.
NCT02200354
Details
2019-08-14
Interventional
220 
Bevacizumab Pemetrexed
Carcinoma, Non-… Lung Neoplasms Advanced Non-sm…
inclusion speed
-
NCT01659021
2012-001236-65
Details
2019-08-14
Interventional
3
[6 Refs]
261 
Idelalisib Ofatumumab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
-
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NCT01349673
Details
2019-08-14
Interventional
3114 
Budesonide
Proctitis Proctocolitis Ulcer Proctosigmoidit…
Terminated for non-safety reasons when Sponsor felt that sufficient long-term safety data was obtained.
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NCT02338973
Details
2019-08-13
Interventional
1/24 
Interferon-gamm… Interferons
Cone Dystrophy Cone-Rod Dystro… Macular Edema Retinal Degener… Inherited Ophth… Inherited Retin…
-
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NCT02012192
2013-003868-31
Details
2019-08-13
Interventional
1/2133 
Paclitaxel
Carcinoma, Ovar… Fallopian Tube … Ovarian Neoplas… Epithelial Ovar… Fallopian Tube … Primary Periton…
production of IMP has stopped
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NCT03547154
Details
2019-08-12
Interventional
2/3344 
Interferon alph… Interferon-alph… Interferons Peginterferon a…
Leukemia Leukemia, Myelo… Leukemia, Myelo… Chronic Myeloge…
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AE Preferred Terms were converted from WHO-ART dictionary to the MedDRA version 10.0