Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02598310
Details
2019-08-28
Interventional
2-
Paclitaxel Trastuzumab
Breast Neoplasm… Breast Cancer Estrogen Recept… HER-2 Positive …
-
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NCT02438787
2015-000288-16
Details
2019-08-28
Interventional
3315 
Golimumab Ustekinumab
Axial Spondyloa… Spondylarthriti… Spondylitis
This study was stopped because ustekinumab did not achieve key endpoints in a related study. The safety profile was consistent with past ustekinumab studies.
The study was discontinued before it was fully enrolled due to lack of efficacy of either dose of ustekinumab in the CNTO1275AKS3001 (NCT02437162) study.
NCT02437162
2014-003679-48
Details
2019-08-28
Interventional
3347 
Golimumab Ustekinumab
Axial Spondyloa… Spondylarthriti… Spondylitis
Neither dose achieved the study's primary or major secondary endpoints. The safety profile was consistent with previous ustekinumab studies.
The study was terminated since neither dose achieved the study's primary or major secondary endpoints.
NCT02054338
2006-001139-23
Details
2019-08-28
Interventional
31004 
Gemcitabine Paclitaxel
Breast Neoplasm… Advanced Breast…
Study was stopped before progressive disease or death of alive subjects.
None reported
NCT02013375
Details
2019-08-28
Interventional
22 
Alemtuzumab Cyclophosphamid… Sirolimus
Anemia, Sickle … Sickle Cell Dis…
-
-
NCT01189409
Details
2019-08-28
Interventional
470 
Sennosides
Constipation Opioid-Induced … Cancer
This study was terminated based on results of interim analysis.
-
NCT01090414
Details
2019-08-28
Interventional
1/2
[28 Refs]
202 
Idelalisib
Leukemia, Lymph… Leukemia, Lymph… Lymphoma, Non-H… Chronic Lymphoc…
-
-
NCT01016262
Details
2019-08-28
Interventional
3119 
Mesalamine
Proctitis Ulcer Proctitis, Ulce…
The decision was taken solely for business/administrative reasons, no safety considerations entered into this. Ongoing randomized patients to complete.
The study was terminated because of business/administrative reasons and not because of safety considerations.
NCT00167206
Details
2019-08-26
Interventional
1/216 
Cyclophosphamid… Fludarabine
Anemia Fanconi Anemia Fanconi Syndrom…
Treatment with thymic shielding found safe, another study started.
Study ended early as thymic shielding was found to be safe. Therefore, a new study was designed using thymic shielding.
NCT03232307
Details
2019-08-22
Interventional
20 
Antibodies Antibodies, Mon… Antineoplastic … BB 1101 Dexamethasone Dexamethasone a… Ibrutinib Immunoglobulins Lenalidomide Rituximab
Lymphoma Lymphoma, Mantl… CCND1 Positive CD20-Positive N… Mantle Cell Lym…
Sponsor does not wish to proceed
-
NCT03726281
Details
2019-08-21
Interventional
20 
Nivolumab
Neoplasms, Germ… Germ Cell Tumor…
End of Agreement between BMS and SGHL
-
NCT03395873
Details
2019-08-21
Interventional
17 
Avelumab Decitabine
Acute Myeloid L…
Recent FDA approval of a new drug for the same patient population
-
NCT02275806
Details
2019-08-21
Interventional
24 
Camptothecin Irinotecan
Carcinoma, Non-… Lung Neoplasms Lung Neoplasms,…
PI decided to terminate study
-
NCT00836069
Details
2019-08-21
Interventional
35 
Paroxetine
Anxiety Disorde…
Pfizer has terminated the execution of this protocol
-
NCT03226080
Details
2019-08-20
Interventional
40 
Rocuronium
Fractures, Bone Hip Fractures Anesthesia, Gen… Anesthesia, Spi… Neuromuscular B…
Study terminated with IRB on 20Feb2019 due to lack of enrollment.
-
NCT03031340
Details
2019-08-20
Interventional
33 
Pregabalin
Spinal Fusion
Incidence of AE
-
NCT02871323
Details
2019-08-20
Interventional
10 
Antibodies, Mon… Durvalumab Immunoglobulin … Immunoglobulins
Polycythemia Polycythemia Ve… Primary Myelofi… Polycythemia Ve…
PI decided to withdraw the study after it opened for enrollment but before any patients were enrolled
-
NCT02605824
Details
2019-08-20
Interventional
41 
Acetylcysteine N-monoacetylcys…
Asthma
The study was closed after we determined that this albuterol/NAC regimen may be associated with excessive bronchoconstriction.
-
NCT02196207
Details
2019-08-20
Interventional
30 
Antibodies, Bis…
Hemophilia A Severe Hemophil…
The trial was revised to be two protocols, one Prevention, one Eradication Trials.
-
NCT01539291
2011-006293-72
Details
2019-08-20
Interventional
3
[3 Refs]
161 
Idelalisib
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
-
-