Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03988114
2019-001781-16
Details
2019-09-06
Interventional
40 
Aromatase Inhib…
Breast Neoplasm… Metastatic Brea…
Strategic decision due to emerging new data for patients with HR+, HER2- metastatic breast cancer.
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NCT02902809
Details
2019-09-06
Interventional
328 
Antibodies, Mon…
Asthma Inadequately Co…
The study was terminated due to the discontinuation of the tralokinumab asthma program (as per the results of the Phase III study [D2210C00008])
Study was terminated due to discontinuation of tralokinumab asthma program. Study was reported in a synopsis format. Individual listings of laboratory variables, physical examinations, vitals and ECG were evaluated for safety signal.
NCT02789189
Details
2019-09-06
Interventional
2-
Gemcitabine Nedaplatin
Carcinoma Nasopharyngeal … Recurrent and M…
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NCT02674893
Details
2019-09-06
Interventional
448 
Liraglutide
Diabetes Mellit… Diabetes Mellit… Overweight Type 2 Diabetes
Exploratory protocol, convincing results, robust analysis
-
NCT02302339
Details
2019-09-06
Interventional
2132 
Antibodies, Mon… Glembatumumab v… Nivolumab Pembrolizumab
Melanoma
Development of glembatumumab vedotin was discontinued
Study was discontinued early, leading to small number of subjects analyzed in Cohort 4 and minimal patient follow up in Cohorts 3 and 4.
NCT01679405
Details
2019-09-06
Interventional
19 
Afatinib Cisplatin Gemcitabine
Neoplasm Metast… Metastatic Dise…
No sufficient clinical or molecular signals for efficacy were observed.
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NCT01408160
Details
2019-09-06
Interventional
118 
Cytarabine Immunotoxins
Leukemia Leukemia, Lymph… Precursor Cell … Adult B Acute L… Recurrent Adult…
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NCT01335867
Details
2019-09-06
Interventional
232 
Vigabatrin
Alcoholism Cocaine-Related… Cocaine Depende…
interim analysis of efficacy completed and termination recommended
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NCT01938664
Details
2019-09-04
Interventional
230 
Candesartan Candesartan cil…
Cocaine-Related… Cocaine Depende…
Results of interim efficacy analysis showed results were not promising.
-
NCT01182350
Details
2019-09-04
Interventional
2
[1 Refs]
53 
Bevacizumab Erlotinib Hydro… Temozolomide
Diffuse Intrins… Glioma
Per design: Stop if fewer than 3 cohorts by molecular classification were with 10 participants or only 1 cohort enrolled at least 15 participants of 50.
The study was terminated early having met the pre-specified stopping rule which required 3 or more cohorts with at least 10 patients each or 2 cohorts with at least 15 patients each in the first 50 patients with informative biopsies.
NCT02614508
Details
2019-09-03
Interventional
11 
Antibodies, Mon… Ibrutinib Ofatumumab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Recurrence Recurrent Chron… Recurrent Small… Refractory Chro… Refractory Smal…
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NCT01648465
2011-006160-48
Details
2019-09-03
Interventional
225 
Everolimus
Digestive Syste… Gastrointestina… Intestinal Neop… Neoplasms Neuroendocrine … Pancreatic Neop… Stomach Neoplas… Gastrointestina… Gastrointestina… Pancreatic Neur… Pancreatic Tumo…
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NCT02982395
Details
2019-08-30
Interventional
336 
Docetaxel Ethanol Mitomycin Mitomycins
Non-Muscle Inva… Urinary Bladder… Non Muscle Inva…
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NCT02972450
Details
2019-08-29
Interventional
1/21 
Vaccines Vedolizumab
Communicable Di… Infections Persistent Infe… HIV-1-infection
Due to the bankruptcy of FITBiotech, the provider of the GTU DNA vaccine.
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NCT03785184
Details
2019-08-28
Interventional
20 
Dexamethasone Lenalidomide Venetoclax
Multiple Myelom… Neoplasms, Plas…
Strategic considerations
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NCT03602118
Details
2019-08-28
Interventional
30 
Phenobarbital
Seizures Neonatal Seizur…
Sponsor withdrawing the subject IND
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NCT03582007
Details
2019-08-28
Interventional
32 
Anti-Bacterial … Murepavadin
Healthcare-Asso… Pneumonia
Safety data review
-
NCT03409679
Details
2019-08-28
Interventional
341 
Anti-Bacterial … Murepavadin
Pneumonia
Safety data review
-
NCT03407404
Details
2019-08-28
Interventional
2/3124 
Ketamine Midazolam Morphine
Critical Illnes…
Futility
-
NCT02918708
Details
2019-08-28
Interventional
40 
Heptavalent Pne…
Immunization Vaccination
funding channel amended by UK department of health
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