Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02735694
Details
2019-09-17
Interventional
118 
Cycloserine
Apnea Sleep Apnea Syn…
Analysis of initial sample shows negative results.
-
NCT01891357
2012-003679-21
Details
2019-09-17
Interventional
264 
Lapatinib Paclitaxel Trastuzumab
Carcinoma, Duct… Carcinoma, Duct…
Early termination due to significant lack of relevant patient data for evaluation of objectives.
Only a limited number of core biopsies was available evaluation of dynamic biological changes. Very slow patient recruitment. Negative study results from ALTTO study did no longer justify further conduct.
NCT00972023
Details
2019-09-17
Interventional
11 
Dehydroepiandro…
Breast Neoplasm… Breast Cancer
-
-
NCT03878654
Details
2019-09-16
Interventional
111 
Ursodoxicoltaur…
Asthma
IRB protocol violations
-
NCT02797704
Details
2019-09-16
Interventional
1/2
[6 Refs]
6 
Aflibercept
Corneal Neovasc… Neovascularizat…
the treatment was found to be inefficient for all recruited patients
-
NCT03182257
Details
2019-09-13
Interventional
11 
ONO-7579
Neoplasms Solid Tumor
The study was stopped for commercial reasons. No safety issues were reported.
-
NCT01500785
2011-002643-10
Details
2019-09-13
Interventional
450 
Hydroxocobalami… Simendan Vitamin B 12
Myocardial Stun…
Change of schedule
-
NCT00661973
2007-006664-29
Details
2019-09-13
Interventional
40 
Budesonide
Asthma
The study was withdrawn for administrative reasons
-
NCT03854942
Details
2019-09-12
Interventional
143 
Naltrexone
Alcoholism Alcohol Addicti…
Recruitment rate could not be met in the study period, review group was dissolved before regular end of study. Recruitment was therefore terminated.
-
NCT03522987
Details
2019-09-12
Interventional
40 
Escitalopram
Anxiety Disorde… Depression Depressive Diso… Epilepsy Anxiety
Decided not to perform the pilot phase
-
NCT03291249
Details
2019-09-12
Interventional
20 
Omeprazole
Diabetes Mellit… Diabetes Mellit… Fatty Liver Non-alcoholic F… NAFLD NASH - Nonalcoh… T2DM (Type 2 Di…
Due to MOH request.
-
NCT02011620
Details
2019-09-11
Interventional
40 
Isosorbide Isosorbide Dini… Isosorbide-5-mo…
Bone Diseases Diabetes Mellit… Diabetes Mellit… Bone Disease Endothelial Dys…
The sponsor was no longer in a position to sponsor a CTIMP. Study did not open.
-
NCT03397186
Details
2019-09-10
Interventional
20 
Trabectedin
Liposarcoma Liposarcoma, My… Sarcoma Metastatic Soft… Myxoid Liposarc… Round Cell Lipo… Stage III Soft … Stage IV Soft T… Unresectable So…
Administrative
-
NCT02688764
Details
2019-09-10
Interventional
385 
Calcium Calcium acetate
Hyperphosphatem…
The study was prematurely ended due to the modification of study requirements by the US Food and Drug Administration and the European Medicines Agency
The study was prematurely ended as a result of the modification of study requirements, as agreed with the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA).
NCT02615938
2013-003714-40
Details
2019-09-10
Interventional
2-
Hydroxychloroqu…
Lung Diseases Lung Diseases, … Children´s Int… Diffuse Parench… Interstitial Lu…
Correction of inspection findings
-
NCT02187367
2013-005335-25
Details
2019-09-10
Interventional
3106 
Cyclophosphamid…
Carcinoma, Non-…
Sponsor decision based on slow recruitment and new emerging drug combinations
-
NCT02058108
2012-004942-14
Details
2019-09-10
Interventional
353 
Telbivudine
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Herpesviridae I… Virus Diseases Chronic Hepatit…
Study terminated on the recommendation of an independent Data Monitoring Committee (DMC) subsequent to an interim efficacy analysis for futility.]
Due to early termination of the study and limited number of enrolled patients on track to complete 52 weeks of participation (8 patients overall), no formal analysis of Weeks 52 and 104 long-term efficacy endpoints (only descriptive analysis).
NCT03638635
Details
2019-09-09
Interventional
463 
Bupivacaine
Pain, Postopera… Colectomy Colorectal Surg… Opioid Use
Lack of personnel available to complete study.
Early termination due to lack of resources leading to incomplete data.
NCT02772120
Details
2019-09-09
Interventional
40 
Progesterone
Infertility
Before enrollment, suspended due to changing insurance coverage of study drugs.
-
NCT02289274
Details
2019-09-09
Interventional
10 
Aceclofenac Eperisone
Healthy
internal decision
-