Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02399917
Details
2019-09-24
Interventional
236 
Azacitidine
Leukemia Leukemia, Biphe… Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Acute Biphenoty… Acute Myeloid L… Recurrent Acute… Refractory Acut…
This study was terminated early due to response rates not meeting the anticipated minimum of 30%.
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NCT01874236
Details
2019-09-24
Interventional
428 
Bupivacaine
Arthralgia SI Joint Pain
Data could not be interpreted. Re-design efforts failed.
-
NCT01873495
Details
2019-09-24
Interventional
27 
Homoharringtoni…
Leukemia, Myelo… Leukemia, Myelo… Acute Myelogeno…
-
Accrual was halted early due to the inability of 30% of subjects to complete the intended consolidation and maintenance.
NCT00727194
Details
2019-09-24
Interventional
2
[1 Refs]
14 
Eculizumab
Muscle Weakness Myasthenia Grav…
-
Small sample size limited ability to detect intercohort differences. Carryover effect from Treatment Period (TP) 1 warrants cautious interpretation of TP 2 data. Study terminated early; 13 patients received eculizumab or placebo in TP2.
NCT00078897
Details
2019-09-24
Interventional
31621 
Selenium
Adenomatous Pol… Colorectal Neop… Polyps Precancerous Co… Adenomatous Col… Colorectal Canc… Precancerous Co…
Concluded - Terminated by PI
-
NCT03315052
Details
2019-09-23
Interventional
4
[1 Refs]
0 
Budesonide Mycophenolic Ac… Prednisone Tacrolimus
Acute Cellular … Liver Transplan…
Delay in IRB approval
-
NCT02618668
Details
2019-09-23
Interventional
290 
Ketamine Propofol
Cholangitis Pancreatitis
-
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NCT01964755
Details
2019-09-23
Interventional
26 
Doxorubicin Formyltetrahydr… Hydroxyurea Leucovorin Levoleucovorin Methotrexate Rituximab Tetrahydrofolat… Zidovudine
Epstein-Barr Vi… Hodgkin Disease Lymphoma Lymphoma, Non-H… Lymphoprolifera… Virus Diseases Epstein Barr Vi… Epstein Barr Vi… Post-Transplant…
Investigator Decision
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NCT03456661
2014-002589-56
Details
2019-09-20
Interventional
4-
Dexmedetomidine Levobupivacaine
Breast Cancer Mastectomy, Mod…
The surgical approach has changed.
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NCT02551055
2015-001032-38
Details
2019-09-20
Interventional
132 
Docetaxel Paclitaxel Serabelisib
Adenocarcinoma Advanced and Me…
Business Decision; No Safety Or Efficacy Concerns.
Due to the early termination of the study, the pharmacokinetic data collected was not processed further. Therefore, the planned secondary endpoints of PK summary statistics are not reported.
NCT01599754
Details
2019-09-20
Interventional
3724 
Axitinib
Carcinoma, Rena… Kidney Neoplasm… Clear Cell Rena…
Primary endpoint did not reach statistical significance
-
NCT00140894
Details
2019-09-20
Interventional
4-
Rofecoxib
Adenomatous Pol… Colorectal Neop… Nasopharyngeal …
-
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NCT03788889
Details
2019-09-19
Interventional
40 
Ketamine Lorazepam Phenobarbital
Substance Withd… Syndrome Alcohol Withdra…
internal practice and policy limitations including time commitment / workflow issues
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NCT03766607
Details
2019-09-19
Interventional
20 
Paclitaxel Ramucirumab Trastuzumab
Stomach Neoplas… Gastric Cancer
Competing other studies
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NCT03286582
Details
2019-09-19
Interventional
210 
Clobetasol
Pemphigoid, Bul… Bullous Pemphig…
Terminated with partial enrollment completed
-
NCT02769169
Details
2019-09-19
Interventional
2/3
[6 Refs]
5 
Ranibizumab
Polypoidal Chor… Vascular Diseas…
study protocol changed
-
NCT01202721
Details
2019-09-18
Interventional
385 
Atenolol Telmisartan
Aortic Valve Di… Bicuspid Aortic… Heart Diseases Cardiac Disease
Terminated early due to lack of study feasibility and poor patient recruitment
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NCT03978494
2018-002672-40
Details
2019-09-17
Interventional
10 
Tacrolimus
Kidney Transpla…
company decision
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NCT03110575
Details
2019-09-17
Interventional
3189 
Cyclobenzaprine
Stress Disorder… PTSD
Stopped early due to inadequate separation on primary efficacy endpoint in the lead-in HONOR study, TNX-CY-P301
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NCT03062540
Details
2019-09-17
Interventional
3358 
Cyclobenzaprine
Stress Disorder… PTSD
Stopped early due to inadequate separation on primary efficacy endpoint at Week 12 according to Interim Analysis conducted on the first 274 (50%) patients.
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