Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03113084
Details
2019-10-14
Interventional
1-
Calcium heparin Heparin
Heparin
Delay in the R&D stage
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NCT02034916
2013-003076-12
Details
2019-10-14
Interventional
284 
Talazoparib
Breast Neoplasm… BRCA 1 Gene Mut… BRCA 2 Gene Mut…
Primary Analysis and study completed. Not stopped due to safety concerns.
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NCT03904849
Details
2019-10-11
Interventional
1/20 
Cannabidiol
Alcohol Drinkin… Alcoholism Alcohol Use Dis…
This study was intended to produce pilot data for a center grant component that will no longer be conducted.
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NCT00422201
Details
2019-10-11
Interventional
218 
Mifepristone
Cardiac Complex… Cushing Syndrom… Syndrome Cushing's Syndr…
-
As a consequence of the premature study end, analyses performed were primarily descriptive due to the reduced number of enrolled and completed patients.
NCT02776891
Details
2019-10-10
Interventional
20 
Citric Acid Gallium citrate Sodium Citrate
Burkitt Lymphom… Lymphoma Lymphoma, Large…
Unexpected dose production issues prevented study start up
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NCT02729961
Details
2019-10-10
Interventional
1/20 
Antibodies Antibodies, Mon… Antineoplastic … Brentuximab Ved… Ceritinib Immunoconjugate… Immunoglobulins
Lymphoma Lymphoma, Large… Lymphoma, Non-H… Anaplastic Larg… CD30-Positive N… Systemic Anapla…
Administrative closure
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NCT01390220
2011-001318-32
Details
2019-10-10
Interventional
3292 
Midazolam
Epilepsy Seizures
-
-
NCT01239342
Details
2019-10-10
Interventional
243 
Everolimus
Carcinoma Carcinoma, Rena… Kidney Neoplasm… Metastatic Kidn… Recurrent Renal… Stage III Renal… Stage IV Renal …
-
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NCT03296098
Details
2019-10-09
Interventional
2-
Ulipristal acet…
Contraception Healthy Female
Awaiting FDA approval to continue
-
NCT02972866
Details
2019-10-09
Interventional
30 
Budesonide
Rhinitis Rhinitis, Aller… Rhinitis, Aller…
Regulatory strategy
-
NCT02111096
2013-004275-12
Details
2019-10-09
Interventional
2174 
Metformin Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit…
The overall benefit-risk profile did not support continued development of LY2409021 for type 2 diabetes.
Terminated, The overall benefit-risk profile did not support continued development of LY2409021 for type 2 diabetes.
NCT02076594
2011-005537-39
Details
2019-10-09
Interventional
3171 
Capecitabine Docetaxel Epirubicin Oxaliplatin
Stomach Neoplas… Locally Advance… Metastatic Gast…
The interim analysis performed on 09 November 2018, showed the failure to achieve the primary objective of effectiveness of the experimental treatment.
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NCT02072096
2013-001473-24
Details
2019-10-09
Interventional
4192 
Acarbose Exenatide Glimepiride Insulin Glargin… Linagliptin Liraglutide Metformin Pioglitazone Sitagliptin Pho…
Diabetes Mellit… Diabetes Mellit…
The trial was terminated per protocol because of lack of feasibility.
The trial was terminated per protocol due to lack of feasibility. All participants completed the first 24 weeks of the study. Some participants continued into the Core study. Data was assessed from Baseline to last participant visit, up to 72 weeks.
NCT01545817
Details
2019-10-09
Interventional
274 
Everolimus
Carcinoma Carcinoma, Rena…
As the therapeutic landscape in renal cell carcinoma is changing, it has become apparent that information gained so far by CATChEz study is sufficient.
the trial terminated early because the information gained from this study was sufficient to meet the objectives for which the study had been set up and would be no longer clinically relevant for the second-line management of RCC patients.
NCT03104816
Details
2019-10-08
Interventional
428 
Acetaminophen Hydromorphone
Fusion of Spine…
Could not get an approval from Department Reviewer for the study continuation.
The trial was not completed and had very small amount of participants.
NCT02968901
Details
2019-10-08
Interventional
446 
Macitentan Tadalafil
Familial Primar… Hypertension Pulmonary Arter…
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NCT02227784
Details
2019-10-08
Interventional
3366 
Atorvastatin Evacetrapib Ezetimibe
Hyperlipidemias Hyperlipoprotei… Hyperlipidemia
Study termination due to program termination.
Early termination was due to program termination.
NCT01683656
Details
2019-10-08
Interventional
44 
Niacin
Atherosclerosis HIV
Withdrawal of IMP from the market. Data on risk-benefit ratio pending.
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NCT01352663
Details
2019-10-08
Interventional
30 
Insulin Insulin Glargin…
Diabetes Mellit… Type I Diabetes
Business strategy decision
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NCT01332331
2010-019547-19
Details
2019-10-08
Interventional
241 
Ambrisentan
Hypertension Hypertension, P… Pulmonary Arter…
Ongoing juvenile rat toxicology studies.
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