Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00626210
Details
2019-10-28
Interventional
42 
Modafinil
Alzheimer Disea… Sleep Initiatio… Insomnia
-
Early termination leading to small numbers of subjects analyzed
NCT03028129
Details
2019-10-25
Interventional
4467 
Anti-Bacterial … Isoniazid
Tuberculosis Tuberculosis, P… Antibiotic Prop…
Interim analysis showed efficacy less than 2.5%.
Loss to follow-up Interruption of the study Arms presented differential group allocation Statistical power to detect the primary endpoint was 73%, lower than estimated in our sample size calculation
NCT02124850
Details
2019-10-25
Interventional
1
[1 Refs]
18 
Cetuximab Nivolumab
Squamous Cell C… Squamous Cell C…
-
-
NCT02408328
Details
2019-10-24
Interventional
20 
Caffeine Caffeine citrat…
Apnea
Transition to new position
-
NCT04012255
2018-003923-13
Details
2019-10-23
Interventional
129 
Semaglutide
Obesity Overweight
The trial was terminated for strategic reasons.
-
NCT03996486
2018-004566-34
Details
2019-10-22
Interventional
10 
Antibodies, Mon… Immunoglobulin … Immunoglobulins Lipoprotein-ass… Myeloma Protein… Paraproteins
Hemophilia A Hemophilia
Company decision
-
NCT03080480
Details
2019-10-22
Interventional
1/23 
Pioglitazone
Granuloma Granulomatous D… Chronic Granulo…
The results are negtive.
-
NCT01729104
Details
2019-10-22
Interventional
118 
Lenalidomide Rituximab
Lymphoma
Low response
-
NCT00866333
Details
2019-10-22
Interventional
249 
Entinostat
Hodgkin Disease Lymphoma Hodgkin's Lymph…
Terminated prior to completion of accrual per corporate decision.
-
NCT02500901
Details
2019-10-21
Interventional
12 
Niraparib
Prostatic Neopl… Metastatic Pros…
Suspended by funder
Study was terminated early by the funder.
NCT01766336
2012-005524-15
Details
2019-10-21
Interventional
2296 
Inositol
Aggression Alzheimer Disea… Psychomotor Agi… Alzheimer's Dis…
-
-
NCT01674010
2012-001935-30
Details
2019-10-21
Interventional
2309 
Inositol Lamotrigine Valproic Acid
Bipolar 1 Disor…
Business Decision
-
NCT03316339
Details
2019-10-18
Interventional
3316 
Dexmedetomidine Remifentanil
Opioid-Related … Anesthesia
Sponsor's decision
-
NCT03281681
Details
2019-10-18
Interventional
1/20 
Dianhydrogalact…
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Alternate study design for ovarian cancer under discussion
-
NCT00407407
NCT00405223
Details
2019-10-18
Interventional
16 
Albumin-Bound P… Carboplatin
Carcinoma Fallopian Tube … Neoplasms Ovarian Neoplas… Peritoneal Neop…
MTD not determined
-
NCT04130399
Details
2019-10-17
Interventional
20 
Folfirinox
Pancreatic Neop… Pancreatic Aden… Pancreatic Canc…
Study is being abandoned.
-
NCT02192697
Details
2019-10-17
Interventional
1/2124 
Naquotinib
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies.
-
NCT01747499
Details
2019-10-16
Interventional
1/254 
Azacitidine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Precursor Cell …
Enrolling 8 more patients would be statistically unlikely that the primary endpoint would be reached (reduce day 180 grade II-IV GVHD rates to 20% or less)
-
NCT03125187
Details
2019-10-15
Interventional
1-
Calcium heparin Heparin
Heparin
Delay in the R&D stage
-
NCT02657369
2015-001929-17
Details
2019-10-15
Interventional
234 
Lenvatinib
Carcinoma Thyroid Carcino… Thyroid Disease… Thyroid Neoplas…
Overall response rate was 3% (only 1 out of 33 participants had confirmed PR).
The study was terminated since overall response rate was 3% (only 1 out of 33 participants had confirmed PR).