Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01021423
Details
2019-11-19
Interventional
39 
Lenalidomide
Lymphoma Lymphoma, Mantl… Lymphoma, Non-H… Mantle Cell Lym… Non-Hodgkin's L…
Terminated by sponsor due to new unpublished data that rendered the current design of the study no longer clinically relevant. There were no safety concerns.
Study terminated early. Most analyses were not performed.
NCT00670748
Details
2019-11-19
Interventional
245 
Aldesleukin Cyclophosphamid… Fludarabine Fludarabine pho…
Carcinoma, Rena… Melanoma Neoplasm Metast… Neoplasms Neoplasms, Seco… Metastatic Canc… Metastatic Mela… Metastatic Rena…
A more highly selected protocol with ESO TCR opened for pts with melanoma
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NCT00537511
Details
2019-11-19
Interventional
1/2
[1 Refs]
22 
Etoposide Etoposide phosp… Pomalidomide
Carcinoma, Smal…
This study was terminated for administrative reasons.
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NCT03665350
2018-001057-26
Details
2019-11-18
Interventional
210 
Insulin
Diabetes Mellit… Diabetes Mellit… Heart Failure
Insulin-HF study was prematurely ended due principally to low recruitment rate.
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NCT02853071
Details
2019-11-18
Interventional
20 
Estramustine
Breast Neoplasm… Breast Cancer
withdrawal industrial
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NCT02452970
Details
2019-11-15
Interventional
24 
Gemcitabine
Cholangiocarcin…
Resensitization or clinical benefit was not observed
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NCT02343939
2016-003353-16
Details
2019-11-15
Interventional
1/2148 
Azacitidine Cytarabine Daunorubicin Decitabine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
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NCT02299115
Details
2019-11-14
Interventional
30 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph… Vigabatrin
Spasm Spasms, Infanti… Infantile Spasm…
Most centres are now using oral steroids as 1st line treatment so question of efficacy is no longer of high interest.
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NCT00531271
Details
2019-11-14
Interventional
1/2-
Docetaxel
Breast Neoplasm… Metastatic Brea…
-
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NCT00529373
Details
2019-11-14
Interventional
316071 
Calcium Calcium Carbona… Calcium, Dietar… Cholecalciferol Vitamin D
Osteoporosis Osteoporosis, P… Postmenopausal …
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The study was terminated early due to an observed increase in risk of stroke in Protocol MK-0822-018.
NCT00109109
Details
2019-11-14
Interventional
1
[1 Refs]
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Vorinostat
Multiple Myelom… Neoplasms, Plas…
-
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NCT03675854
Details
2019-11-13
Interventional
40 
Cefazolin
Peritonitis Peritoneal Dial…
New data from another study show that a positive result is unlikely.
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NCT01118975
Details
2019-11-13
Interventional
1/212 
Lapatinib Vorinostat
Breast Neoplasm… Neoplasm Metast… Breast Cancer
Lost sponsorship for study drug
The most important limitation of this study is that the Phase II efficacy portion was terminated early by the sponsor.
NCT03477864
Details
2019-11-12
Interventional
10 
Antibodies Antibodies, Mon… Antineoplastic … Cemiplimab Immunoglobulins Ipilimumab
Prostatic Neopl… Stage III Prost… Stage IIIA Pros… Stage IIIB Pros… Stage IIIC Pros… Stage IV Prosta… Stage IVA Prost… Stage IVB Prost…
Study was not accruing
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NCT02661815
Details
2019-11-08
Interventional
16 
Bevacizumab Paclitaxel Ricolinostat
Fallopian Tube … Fallopian Tube … Ovarian Cancer Primary Periton…
Company decided not to move forward with further accrual.
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NCT02741076
Details
2019-11-06
Interventional
444 
Analgesics, Opi… Morphine Oxycodone Oxymorphone
Chronic Pain Narcotic-Relate… Opioid-Related … Substance-Relat… Drug Abuse Narcotic Abuse Opiate Addictio…
Inability to recruit sufficient no. of subjects over an acceptable time period
This study was terminated because it could not recruit the planned study population. Randomized study participants were too few to show changes in pain intensity scores or clinical effects. The safety profile reflects current prescribing information.
NCT03678792
Details
2019-11-05
Interventional
30 
Buprenorphine Buprenorphine, … Morphine Naloxone Tramadol
Opioid-Related … Opioid Withdraw…
Infeasible to conduct at this time.
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NCT03154333
Details
2019-11-05
Interventional
254 
Diacerein
Epidermolysis B… Epidermolysis B…
Futility
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NCT02289222
Details
2019-11-05
Interventional
1/248 
Dexamethasone Pembrolizumab Pomalidomide
Multiple Myelom… Neoplasms, Plas…
Due to the inclusion of an IMid in combination with pembrolizumab, Study Sponsor terminated the study.
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NCT00730847
2017-000458-20
Details
2019-11-05
Interventional
4743 
Vaccines
Papillomavirus … Human Papilloma…
GSK received exemption from PDFDA on conduct of this post-marketing surveillance (PMS) study.
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