Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00299988
Details
2019-12-11
Interventional
224 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Alzheimer Disea… Alzheimer's Dis…
-
The study was terminated due to the results from another phase III study with IVIG: PMC5409846, NCT00818662
NCT02689219
Details
2019-12-10
Interventional
218 
Brentuximab Ved…
Carcinoma, Embr… Neoplasms Neoplasms, Germ… Testicular Neop… Embryonal Carci… Germ Cell Tumor… Nonseminomatous… Testicular Canc… Testis Cancer
lack of funding/ benefit
-
NCT02115386
Details
2019-12-10
Interventional
37 
Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Philadelphia Po…
Study was terminated by Novartis
-
NCT01218867
Details
2019-12-10
Interventional
1/224 
Aldesleukin Cyclophosphamid… Fludarabine
Kidney Neoplasm… Melanoma Neoplasm Metast… Neoplasms Neoplasms, Seco… Metastatic Canc… Metastatic Mela… Renal Cancer
No objective responses were observed.
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NCT02434146
Details
2019-12-09
Interventional
1/23 
Oxymetazoline Phenylephrine
Neoplasm Oral Mucosa Transplant-Rela…
A company in China has decided to license the product
This study was closed prematurely due to decreased numbers of eligible subjects. The full target accrual number was not achieved, and no study conclusions could be made.
NCT01816048
Details
2019-12-09
Interventional
28 
Fluorides Listerine Sodium Fluoride
Prostatic Neopl… Prostate Cancer
Study supporter (Takeda) ended study drug for prostate cancer; enrollment ended prematurely.
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NCT00985946
Details
2019-12-09
Interventional
215 
Panobinostat
Neuroendocrine …
Study did not meet statistical requirements to continue.
This study was terminated early because of the use of objective response rate as the primary outcome measure, which is a shortcoming of this study.
NCT03851263
Details
2019-12-06
Interventional
40 
Evolocumab
Coronary Artery…
Admisnitrative issues
-
NCT01797965
2012-003176-39
Details
2019-12-04
Interventional
31501 
Daclizumab
Multiple Sclero… Multiple Sclero… Sclerosis Relapsing-Remit…
Study terminated because of differences in the participant population under study compared with indicated Zinbryta use in most countries.
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NCT01258868
Details
2019-12-03
Interventional
144 
Celecoxib
Esophageal Neop… Mesothelioma Mesothelioma, M… Sarcoma Thymoma Esophageal Canc… Lung Cancer Mesolthelioma Thoracic Sarcom…
-
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NCT02825342
Details
2019-12-02
Interventional
460 
Citalopram Proton Pump Inh…
Chest Pain Infarction Myocardial Infa… Chest Pain Rule…
Primary endpoint was reached.
-
NCT01157975
Details
2019-12-02
Interventional
20 
Pioglitazone Prednisone
Hepatitis Hepatitis A Hepatitis C
Study was completed in another site
-
NCT02527460
Details
2019-11-29
Interventional
11 
Interleukin 1 R…
Communicable Di… Infections Nervous System … Neuroinflammato… HIV Infections Neurologic Diso…
-
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NCT01375556
Details
2019-11-29
Interventional
133 
Ethanol
Alcoholism Genetics
-
-
NCT00230490
Details
2019-11-29
Interventional
2-
Adefovir Pradefovir
Hepatitis Hepatitis B Hepatitis B, Ch…
Adverse findings from nonclinical carcinogenicity studies.
-
NCT03343067
Details
2019-11-27
Interventional
311 
Estradiol Norethindrone Norethindrone A…
Endometriosis
The study was terminated early for business reasons, not for safety concerns.
Due to early study termination at Treatment Month 6 with low subject enrollment, no clinically or statistically meaningful efficacy conclusions can be made. The study was terminated early for business reasons, not for safety concerns.
NCT03811418
2017-004749-25
Details
2019-11-26
Interventional
30 
Docetaxel Pertuzumab Trastuzumab Vinorelbine
Breast Neoplasm… Advanced Breast… HER2-positive B…
Study approved with treatment regimen based on current guidelines. However, reimbursement of IMP was not feasible.
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NCT02112045
Details
2019-11-26
Interventional
290 
Melphalan
Multiple Myelom… Neoplasms, Plas…
Terminated due to results of interim analysis
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NCT00140140
Details
2019-11-26
Interventional
1/216 
Albumin-Bound P… Lenograstim Paclitaxel Trastuzumab Vinorelbine
Breast Neoplasm… Stage IV (Metas…
Unable to determine the optimum tolerated dose
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NCT03335293
Details
2019-11-25
Interventional
40 
Epinephrine Epinephryl bora… Racepinephrine
Cesarean Sectio… Pregnancy
Due to FDA constraints on the off label use of the medications we will not be able to conduct this evaluation.
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