Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03923361
Details
2019-12-18
Interventional
2/30 
Propofol
Depressive Diso… Treatment Resis…
Change in study design based on phase 1 data collection; patient burden was not feasible
-
NCT03269318
Details
2019-12-18
Interventional
42 
Montelukast Salmeterol Xina… Theophylline
Asthma
Change to Primary Endpoint resulted in development of new protocol
-
NCT01445340
NCT00477698
Details
2019-12-17
Interventional
16 
Romidepsin
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Lymphoma, T-Cel… Mycoses Mycosis Fungoid… Cutaneous T-Cel… Neoplasms
-
-
NCT01441128
Details
2019-12-17
Interventional
120 
Crizotinib Dacomitinib
Carcinoma Carcinoma, Larg… Carcinoma, Non-… Carcinoma, Squa… Lung Neoplasms Adenocarcinoma Carcinoma, Non-…
-
-
NCT01336985
Details
2019-12-17
Interventional
15 
Irinotecan
Colorectal Neop… Melanoma Neoplasm Metast… Neoplasms Neoplasm Metast…
-
-
NCT01122914
Details
2019-12-17
Interventional
11 
Interleukin 1 R…
Dermatitis Dermatitis, Ato… Eczema Allergic Diseas… Anakinra Atopic Dermatit… Kineret
-
-
NCT00973804
Details
2019-12-17
Interventional
14 
Sirolimus Tacrolimus
Hodgkin Disease Leukemia Lymphoma Lymphoma, Non-H… Multiple Myelom… Hodgkins Lympho… MDS Non-Hodgkins Ly…
-
-
NCT00754221
Details
2019-12-17
Interventional
3390 
Reboxetine
Fibromyalgia Myofascial Pain…
This study has been terminated early as the esreboxetine development program is being discontinued. There are no safety or efficacy concerns.
-
NCT00688805
Details
2019-12-17
Interventional
140 
Propranolol
Cocaine-Related… Cocaine Depende…
-
-
NCT00428272
NCT01445093
Details
2019-12-17
Interventional
130 
Antibodies, Mon… Interferon-gamm… Interferons Lexatumumab
Neuroblastoma Osteosarcoma Rhabdomyosarcom… Sarcoma Sarcoma, Ewing Ewing's Sarcoma
-
-
NCT00327080
Details
2019-12-17
Interventional
120 
Acetylcholine
Hypertension Hypertension, P… HIV
-
-
NCT00334685
Details
2019-12-16
Interventional
2136 
Pregabalin Reboxetine
Pain
The Data Monitoring Committee terminated the study on the basis of futility (insufficient clinical response).
-
NCT00022971
NCT00029367
Details
2019-12-16
Interventional
135 
Rituximab
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, Large… Lymphoma, Mantl… Chronic Lymphoc… Diffuse Large B… Follicular Lymp… Mantle Cell Lym… Small Lymphocyt…
-
-
NCT02806960
Details
2019-12-13
Interventional
112 
Glucagon
Diabetes Mellit… Diabetes Mellit… Diabetes Mellit…
Drug delivery was below target dose due to partial obstruction by aggregated particles.
The study drug was discovered to be delivering a potential sub-target dosing to some participants, due to partial obstruction of the delivery device by aggregation of particles. The study was terminated early with no safety concern for participants.
NCT00607256
Details
2019-12-13
Interventional
3500 
Reboxetine
Fibromyalgia Myofascial Pain…
-
-
NCT00028652
Details
2019-12-13
Interventional
1-
Interleukin-12
Neoplasm Metast… Metastatic Canc…
-
-
NCT02423083
Details
2019-12-12
Interventional
12 
Guanabenz
Multiple Sclero… Multiple Sclero… Sclerosis
-
-
NCT00287495
NCT00304122
Details
2019-12-12
Interventional
110 
Sorafenib
Sarcoma Sarcoma, Kaposi HHV-8 KSHV Kaposi's Sarcom…
-
-
NCT00094978
NCT00098644
Details
2019-12-12
Interventional
123 
Alvocidib Romidepsin
Carcinoma Carcinoma, Non-… Carcinoma, Smal… Esophageal Neop… Mesothelioma Mesothelioma, M…
-
-
NCT03371381
2016-002543-41
Details
2019-12-11
Interventional
1/212 
Nivolumab
Adenocarcinoma Adenocarcinoma …
Development of JNJ-64041757 in combination with nivolumab discontinued due to lack of clinical benefit observed in the Phase 1b portion of the study
Sponsor did not proceed to Randomized phase 2 of study or enroll additional participants in phase 1b as study was stopped early, that resulted in limited evaluation of planned participant-related outcomes, PK, immunogenicity and biomarker analyses.