Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02452385
Details
2020-01-13
Interventional
1-
Vorolanib
Macular Degener… Age-Related Mac…
Sponsor requirements
-
NCT00616122
Details
2020-01-13
Interventional
1/232 
Cyclophosphamid… Methotrexate Sunitinib
Breast Neoplasm… Breast Cancer
Risk to benefit ratio not acceptable
Based on published literature indicating significant toxicity and low response rate for combination sunitinib in the treatment of advanced breast cancer, the PI and Breast Oncology Site Committee closed enrollment after accrual of 32 participants.
NCT03210480
2016-001714-14
Details
2020-01-10
Interventional
485 
Lithium Carbona…
Bipolar Disorde…
Sponsor's decision due to slow enrollment rate.
-
NCT03181685
Details
2020-01-10
Interventional
460 
Cetrorelix Progesterone
Infertility In Vitro Fertil…
27 couples were recruited. This unexpected poor recruitment was due to more clinical pregnancies (for a better patients' selection) and more freeze-all cycles.
-
NCT02259491
Details
2020-01-10
Interventional
410 
Calcium
Wounds and Inju… Wound Healing
-
-
NCT04115020
Details
2020-01-09
Interventional
20 
Naltrexone
Arthritis Arthritis, Psor… Arthritis, Rheu… Chronic Pain Osteoarthritis
A pilot study was negative.
-
NCT04045730
Details
2020-01-09
Interventional
20 
Gemcitabine Paclitaxel Pembrolizumab
Adenocarcinoma Pancreas Adenoc…
Halozyme isn't allowing this trial to move forward until their current clinical trial results are released.
-
NCT04044651
Details
2020-01-09
Interventional
2/30 
Lenvatinib Nivolumab
Carcinoma Carcinoma, Hepa… Hepatitis Hepatitis B Hepatocellular …
Bristol-Myers Squibb company terminated this study
-
NCT02010645
Details
2020-01-02
Interventional
26 
Decitabine
Leukemia Myelodysplastic… Preleukemia Syndrome
PI Request
-
NCT02697292
Details
2019-12-30
Interventional
317 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Epilepsy Autoimmune Epil…
-
-
NCT02628769
2014-003077-42
Details
2019-12-30
Interventional
26 
Solithromycin
Lung Diseases Lung Diseases, … Pulmonary Disea…
-
Limitations of the trial such as small numbers of subjects analysed or technical problems leading to unreliable data.
NCT01470742
Details
2019-12-30
Interventional
30 
Capecitabine
Stomach Neoplas… Gastric Cancer
We stop because of problems such as insurance.
-
NCT03471351
Details
2019-12-27
Interventional
12 
Pembrolizumab Tenalisib
Hodgkin Disease Classical Hodgk…
At this point, the current study in HL does not fit into clinical development and regulatory strategy.
-
NCT02544152
Details
2019-12-27
Interventional
271 
Lubiprostone
Irritable Bowel… Syndrome
-
-
NCT02465528
Details
2019-12-27
Interventional
222 
Ceritinib
Glioblastoma Granuloma, Plas… Lymphoma Lymphoma, Large… Neoplasms Anaplastic Larg… Inflammatory My… Tumors With Abe…
-
-
NCT00937768
Details
2019-12-27
Interventional
216 
Goserelin Leuprolide
Prostatic Neopl… Prostate Adenoc… Stage IIA Prost… Stage IIB Prost… Stage III Prost… Stage IV Prosta…
-
-
NCT02115048
Details
2019-12-26
Interventional
244 
Afatinib Letrozole
Breast Neoplasm…
Study was completed as per amended protocol. Protocol was amended to close enrollment earlier than initially planned (study continued as per plan).
Enrolment was closed prematurely with only 44 participants enrolled compared to what was initially planned (150 participants). Thus, preventing appropriate statistical evaluation (primary/secondary objectives no longer applicable as per protocol).
NCT03693391
2018-002539-98
Details
2019-12-19
Interventional
122 
Fluorides
Healthy
stopped because of a business decision
-
NCT02790957
Details
2019-12-19
Interventional
225 
Plerixafor
Chronic Limb-Th… Wounds and Inju… Critical Limb I… Diabetes Wounds
Safety reasons
-
NCT01887691
Details
2019-12-19
Interventional
120 
Eszopiclone
Glucose Intoler… Prediabetic Sta… Diabetes Prediabetes Prediabetic
-
-