Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03967288
Details
2024-02-16
Interventional
427 
Bupivacaine Chloroprocaine Procaine
Anesthesia, Spi…
Four patients required conversion to GETA (2 in each study arm)
-
NCT03940690
Details
2024-02-16
Interventional
3-
Bevacizumab
Retinal Telangi… Telangiectasis Coats Disease
awaiting results of interim analysis
-
NCT02315157
Details
2024-02-16
Interventional
10 
Bendamustine Hy…
Leukemia, Plasm… Multiple Myelom… Neoplasms, Plas… Plasma Cell Leu…
Withdrawn by PI
-
NCT06018116
Details
2024-02-15
Interventional
20 
Antibodies, Mon… Avelumab Bicalutamide
Carcinoma, Tran… Metastatic Urot…
Results of EV302 study do not make it feasible to complete a study in second line avelumab immunotherapy. The new standard of care make this study not pertinent.
-
NCT05378763
Details
2024-02-15
Interventional
3-
Docetaxel
Carcinoma, Non-… NSCLC
The study has not enrolled any patients. The study design is under discussion and will likely be redesigned in consultation with the FDA.
-
NCT04428333
2019-003981-42
Details
2024-02-15
Interventional
2/3118 
Fluorouracil Pembrolizumab
Carcinoma Carcinoma, Squa… Head and Neck N… Squamous Cell C… Neoplasms, Head…
The trial was stopped by the sponsor based on assessment of the clinical data
Data are reported following the interim analysis decision to stop further accrual into the study and discontinue feladilimab/placebo. The study primary completion analysis results should be interpreted with consideration of the immature data
NCT04341311
Details
2024-02-15
Interventional
14 
Panobinostat
Brain Neoplasms Diffuse Intrins… Glioma Gliosarcoma Diffuse Glioma Pediatric Brain… Pediatric Brain… Pediatric Brain… Pediatric Cance…
Withdrawal of support from BMS
-
NCT03818776
Details
2024-02-15
Interventional
17 
Durvalumab
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Safety
-
NCT06259630
Details
2024-02-14
Interventional
40 
Nicotine
Tobacco Use Dis… Nicotine Addict… Nicotine Use Di…
Investigators no longer wanted to pursue this research topic
-
NCT05379179
Details
2024-02-14
Interventional
43 
Fentanyl Ketamine
Poisoning Rattlesnake Env…
After 20 months of active enrollment and a lack of qualified/interested subjects, the Investigator, Meghan Spyres, MD, decided to terminate recruitment before meeting the stated enrollment objectives.
Significant limitations were not reaching the target number of patients, extremely low enrollment resulted in termination.
NCT05219604
Details
2024-02-14
Interventional
43 
Diphenhydramine Promethazine
Central Nervous… Pharmacokinetic…
Institution decision
-
NCT04814875
Details
2024-02-14
Interventional
1/216 
Carboplatin Doxorubicin Liposomal doxor…
Carcinoma Carcinoma, Endo… Carcinoma, Ovar… Fallopian Tube … Fallopian Tube … High Grade Seri… Ovarian Cancer Primary Periton…
For technical reasons, it was decided by the sponsor to close the ongoing ovarian cancer study, AM ATX101-03, immediately.
-
NCT04652518
Details
2024-02-14
Interventional
2185 
Pirfenidone
COVID-19 Respiration Dis… Respiratory Tra… Covid19 Post-acute COVI…
Part A of the study was completed; Part B of the study was terminated
-
NCT03958383
Details
2024-02-14
Interventional
1/2-
Ipilimumab Nivolumab
Melanoma
Administrative
-
NCT03179995
Details
2024-02-14
Interventional
223 
Octreotide
Major Liver Res…
Grantor closed study
-
NCT06113289
Details
2024-02-13
Interventional
1/2-
Decitabine and …
Leukemia Leukemia, Myelo… Leukemia, Myelo… Acute Myeloid L…
PI Request
-
NCT04533737
2019-004099-20
Details
2024-02-13
Interventional
4
[1 Refs]
113 
Brodalumab
Psoriasis Plaque Psoriasi… Psoriasis Vulga…
The recruitment was terminated early due to delays and slow recruitment that significantly jeopardized the trial timelines. There were no safety concerns related to the early termination of the trial.
-
NCT04401995
Details
2024-02-13
Interventional
2-
Nivolumab
Melanoma
Evaluation in process, pending new trial with similar agents
-
NCT04162873
Details
2024-02-13
Interventional
2-
Celecoxib
Carcinoma Head and Neck N… Laryngeal Neopl… Oropharyngeal N… Paranasal Sinus… Recurrence Clinical Stage … Clinical Stage … Nasal Cavity an… Oral Cavity Car… Pathologic Stag… Pathologic Stag… Recurrent Hypop… Recurrent Laryn… Recurrent Nasal… Recurrent Oral … Recurrent Oroph… Stage III Hypop… Stage III Laryn… Stage III Oroph… Stage IV Hypoph… Stage IV Laryng… Stage IV Oropha… Stage IVA Hypop… Stage IVA Laryn… Stage IVA Oroph… Stage IVB Hypop… Stage IVB Laryn… Stage IVB Oroph… Stage IVC Hypop… Stage IVC Laryn… Stage IVC Oroph…
Pending confirmation of additional funding
-
NCT02864953
NCT04950972
2017-004854-41
Details
2024-02-13
Interventional
3535 
Glyburide
Brain Edema Edema Infarction Stroke Stroke, Acute
Early completed to operational challenges and other strategic considerations, not for efficacy or safety reasons
Early termination of trial due to operational challenges and other strategic considerations, not for efficacy or safety reasons.