Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03173963
Details
2020-02-25
Interventional
30 
Empagliflozin
Diabetes Mellit… Diabetic Nephro… Kidney Diseases Diabetes Mellit… Diabetic Kidney…
Original drug sponsor withdrew from study, replacement sponsor not obtained.
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NCT03035578
Details
2020-02-25
Interventional
1/20 
Morphine
Drug Effect Pain
research project has been abandoned primarily because of the excessive delays associated with past challenges in obtaining approval from Health Canada
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NCT02541604
2014-004697-41
Details
2020-02-25
Interventional
1/287 
Atezolizumab
Neoplasms Solid Tumor
Sponsor decision to terminate because limited investigational agent activity was observed.
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NCT01749293
Details
2020-02-25
Interventional
23 
Busulfan Cyclophosphamid… Fludarabine
Hematologic Neo… Neoplasms Hematologic Mal…
The protocol design is being reconfigured in order to open a new study.
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NCT02066311
Details
2020-02-24
Interventional
215 
Nelfinavir
Lupus Erythemat… Systemic Lupus …
Stage 1 terminated 6/1/18 prior to completion of Stage 1 due to low enrollment and efficacy
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NCT01629511
Details
2020-02-24
Interventional
1/215 
Antilymphocyte … Busulfan Clofarabine Gemcitabine Lenograstim Methotrexate Tacrolimus Thymoglobulin
Leukemia Leukemia, Lymph… Leukemia, Lymph… Leukemia, Proly… Allogeneic Hema… Chronic Lymphoc… Prolymphocytic … Richter Syndrom…
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Early termination leading to small number of subjects analyzed. This study never moved to Phase II, therefore was not analyzed.
NCT04279938
Details
2020-02-21
Interventional
10 
Pembrolizumab Rituximab
Lymphoma, Large… Relapsed or Ref…
Safety data on drug
-
NCT02134067
Details
2020-02-21
Interventional
130 
Paclitaxel TAS-119
Neoplasms Advanced Solid …
-
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NCT02448589
2014-001272-63
Details
2020-02-20
Interventional
174 
TAS-119
Advanced Solid …
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NCT02134912
Details
2020-02-20
Interventional
21 
Crizotinib Pemetrexed Tyrosine Kinase…
Adenocarcinoma … Carcinoma, Non-… Lung Neoplasms Adenocarcinoma … Large Cell Lung… Recurrent Non-s… Stage IV Non-sm…
science has moved forward and there is no intent to complete the study
The one patient that enrolled immediately withdrew consent [enrolled the day before the study closed]. No manuscript will be forthcoming.
NCT00544700
Details
2020-02-20
Interventional
3265 
Bevacizumab
Colorectal Neop… Colorectal Canc…
Data collection is completed. As no changes in the endpoints were expected in the future, no further data is needed.
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NCT04158700
2019-001156-18
Details
2020-02-19
Interventional
1/20 
Pembrolizumab
Neoplasms Advanced Cancer
The withdrawal is due to a strategic realignment and is not related to any particular safety or efficacy concern.
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NCT04220281
Details
2020-02-17
Interventional
1/240 
Nitroglycerin Propofol
Hypotension Hypotensive Ane…
the number of patients needed for the study have been collected
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NCT03982121
2017-005020-14
Details
2020-02-17
Interventional
10 
Ipilimumab Nivolumab
Colorectal Neop… Colorectal Canc…
Study never began because of withdrawal of the industrial partner
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NCT02596555
Details
2020-02-17
Interventional
4400 
Dabigatran
Embolism Pulmonary Embol…
1. Interim results suggested a reduction of sample size. 2. Anticipated length of enrolment period with resulting funding issues to pose a threat to the study.
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NCT02208063
Details
2020-02-17
Interventional
3121 
Cefazolin Cloxacillin Daptomycin Nafcillin Oxacillin Penicillins Telavancin Vancomycin
Bacteremia
Halted due to lack of statistical power. No safety concerns identified.
At the interim analysis, study was deemed to be inadequately powered & terminated prematurely.
NCT01671488
Details
2020-02-17
Interventional
1/211 
Mitomycin Mitomycins
Anus Neoplasms Anal Cancer
pilot data to be used for upcoming larger trial.
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NCT01669720
Details
2020-02-17
Interventional
210 
Aflibercept
Colorectal Neop… Metastatic Colo…
Lack of efficacy and enrollment
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NCT01057277
Details
2020-02-17
Interventional
13 
Everolimus
Head and Neck N… Head and Neck C…
Pharmaceutical co- re aligned their specialties- no longer will fund H&N ca
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NCT02771925
Details
2020-02-13
Interventional
4
[5 Refs]
25 
Gabapentin
Alcoholism Alcohol Depende…
Due to poor compliance of patients in the study.
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