Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00539188
Details
2020-04-15
Interventional
26 
Acetylcysteine N-monoacetylcys…
Borderline Pers… Personality Dis… Self-Injurious …
Study terminated due to poor subject compliance.
-
NCT03118713
Details
2020-04-14
Interventional
433 
Glimepiride Ipragliflozin Metformin
Albuminuria Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
Business decision due to enrollment challenges
-
NCT01636609
Details
2020-04-13
Interventional
118 
Azacitidine Cytarabine Glycine Tosedostat
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Syndrome Acute Myeloid L… High Risk Myelo…
In 2013 the FDA put a temporary hold on the trial and the Phase II portion of this study was cancelled.
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NCT03093272
Details
2020-04-09
Interventional
29 
Docetaxel Leuprolide Prednisone
Prostatic Neopl… Prostate Cancer
Safety concerns
-
NCT02503501
Details
2020-04-09
Interventional
249 
Insulin glulisi…
Alzheimer Disea… Cognitive Dysfu… Alzheimer's Dis… Mild Cognitive …
Study will not have power to show a difference between groups.
-
NCT02162433
Details
2020-04-09
Interventional
492 
Dexmedetomidine
Hypertrophy Sleep Apnea, Ob… Tonsillitis Adenoiditis Adenotonsillar … Obstructive Sle…
Terminated due to a high number of protocol deviations secondary to non-study approved opioid administration.
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NCT00353457
Details
2020-04-09
Interventional
26 
Capecitabine Cetuximab Oxaliplatin
Adenocarcinoma Rectal Neoplasm… Rectal Cancer
new studies were finding that Erbitux was not beneficial
-
NCT04069234
Details
2020-04-08
Interventional
30 
Clopidogrel Ticagrelor
Coronary Artery… Diabetes Mellit… Myocardial Infa… Microvascular C…
Sponsor decided to stop the study due to commercial reasons.
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NCT03427021
Details
2020-04-08
Interventional
165 
Oxaliplatin
Hypersensitivit… GI Patients on …
final study report has been completed and submitted
-
NCT02263547
Details
2020-04-03
Interventional
114 
Colestipol Teriflunomide
Healthy Volunte… Teriflunomide E…
PK time points were not being met as expected. Determination that risks outweighed benefit.
small number of subjects analyzed with some lost to followup
NCT03002831
Details
2020-04-02
Interventional
2
[2 Refs]
13 
Tegafur
Pancreatic Neop… Advanced Cancer
Study halted prematurely and will not resume
-
NCT01847677
2012-003883-31
Details
2020-04-01
Interventional
271 
Bevacizumab Carboplatin Paclitaxel
Carcinoma, Ovar… Ovarian Neoplas… Cancer, Ovarian
-
-
NCT03680560
Details
2020-03-31
Interventional
16 
Trastuzumab
HER-2 Protein O… Solid Tumor
Business Reasons
-
NCT03232021
Details
2020-03-31
Interventional
2/30 
Pregabalin
Pregabalin on C…
All patients during the study period were subjected to peripheral blocks or were excluded from the study due to exclusion criteria
-
NCT02855086
Details
2020-03-31
Interventional
1/23 
Antibodies Antibodies, Mon… Antineoplastic … Cetuximab Immunoglobulins
Brain Neoplasms Glioma Neoplasms Brain Neoplasm Malignant Gliom…
logistics
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NCT02365870
Details
2020-03-31
Interventional
44 
Rotigotine
Anxiety Disorde… Parkinson Disea…
Funding cycle completed
-
NCT02622724
2014-005260-15
Details
2020-03-30
Interventional
3301 
Interferon beta… Interferon-beta Interferons
Acute Lung Inju… Respiratory Dis… Respiratory Dis… Syndrome Respiratory Dis…
Day 90 results indicate IMP did not reduce mortality or ventilator free days
As the study was terminated early, only a limited amount of data was available at Day 180 and Day 360.
NCT00398008
Details
2020-03-30
Interventional
20 
Buprenorphine Naltrexone
Opioid-Related … Substance-Relat… HIV Infections Opiate Dependen…
Study was never able to start in IRAN
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NCT04132011
Details
2020-03-27
Interventional
40 
Analgesics, Opi… Hydromorphone Morphine Oxycodone
Chronic Pain
No recruitment (Feasibility study).
-
NCT04024384
Details
2020-03-27
Interventional
20 
Daratumumab
Multiple Myelom… Neoplasms, Plas…
Promotor decision
-