Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03212352
Details
2020-05-01
Interventional
4342 
Mifepristone Misoprostol
Early Pregnancy…
Advised by DSMB based on interim-analysis, highly significant difference.
-
NCT03015831
Details
2020-05-01
Interventional
3254 
Colchicine
Atrial Fibrilla… Cardiac Surgery Colchicine Adve…
Statistical analysis of interim data showed no advantage of colchicine
-
NCT00092287
2004-001091-40
Details
2020-04-30
Interventional
34 
Lanreotide Octreotide Somatostatin
Carcinoid Tumor Malignant Carci… Serotonin Syndr… Syndrome
-
-
NCT03400254
Details
2020-04-28
Interventional
1/20 
Gedatolisib Hydroxychloroqu…
Breast Neoplasm… Breast Cancer
due to business decision regarding the study drug.
-
NCT03378973
Details
2020-04-28
Interventional
47 
Dexmedetomidine
Spinal Fusion
No longer clinically relevant
-
NCT02400645
Details
2020-04-28
Interventional
169 
Bupivacaine Ketorolac
Pain, Postopera… Postoperative P…
It was determined that one member of the team had falsified data.
-
NCT00003645
Details
2020-04-28
Interventional
364 
Bicalutamide Flutamide Goserelin Leuprolide
Prostatic Neopl… Recurrence Prostate Cancer
Per PI request
-
NCT00632827
Details
2020-04-27
Interventional
221 
Carmustine Cyclophosphamid… Cytarabine Denileukin dift… Doxorubicin Etoposide Gemcitabine Lenograstim Leucovorin Liposomal doxor… Methotrexate Vincristine Vinorelbine
Lymphoma Lymphoma, T-Cel… Lymphoma, T-Cel… Peripheral T-Ce…
Manufacturing shortage of both Diftitox and Doxil
Enrollment was terminated prematurely due to manufacturing shortages of Doxil and Denileukin Diftitox (Ontak). All eligible patients who received at least one dose of study regimen were included in the analyses
NCT00433342
Details
2020-04-27
Interventional
19 
Floxacillin
Kidney Diseases Renal Insuffici… Chronic Kidney …
-
-
NCT03920839
Details
2020-04-24
Interventional
10 
Carboplatin Gemcitabine Paclitaxel Pemetrexed
Carcinoma, Non-… Mesothelioma Mesothelioma, M… Advanced and/or… Advanced/Metast… Stage IIIB Not …
As of November 4, 2019 the study was halted prematurely and will not resume.
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NCT02452775
Details
2020-04-24
Interventional
13 
Monatide (IMS 3… Poly ICLC
Carcinoma, Ovar… Fallopian Tube … Ovarian Neoplas… Fallopian Tube … Primary Ovarian… Primary Periton…
-
-
NCT01312376
Details
2020-04-24
Interventional
118 
Bevacizumab Cyclophosphamid… Fludarabine Vaccines
Fallopian Tube … Fallopian Tube … Ovarian Carcino… Primary Periton…
-
-
NCT03949842
Details
2020-04-22
Interventional
40 
Adrenergic Agen… Cholinergic Age… Fluticasone Muscarinic Anta… Xhance
Lung Diseases Pulmonary Disea…
The decision to end the study was based on a change in GSK strategy. No subjects were enrolled into the study.
-
NCT03507374
Details
2020-04-21
Interventional
120 
Alirocumab
Atherosclerosis Hemorrhage Intracranial Ar… Intracranial At… Intraplaque Hem… Stroke
Funding withdrawn
-
NCT03075553
Details
2020-04-21
Interventional
212 
Nivolumab
Enteropathy-Ass… Immunoblastic L… Intestinal Dise… Leukemia Leukemia, T-Cel… Leukemia-Lympho… Lymphoma Lymphoma, Extra… Lymphoma, Large… Lymphoma, Non-H… Lymphoma, T-Cel… Lymphoma, T-Cel… Mycoses Mycosis Fungoid… Recurrence Blastic Plasmac… HTLV-1 Infectio… Hepatosplenic T… NK-Cell Lymphom… Primary Systemi… Recurrent Adult… Recurrent Anapl… Recurrent Angio… Recurrent Enter… Recurrent Mycos… Refractory Adul… Refractory Anap… Refractory Angi… Refractory Ente… Refractory Myco… Refractory Nasa… Refractory Peri…
due to poor response
-
NCT00776373
Details
2020-04-21
Interventional
1/24 
Cytarabine Etoposide Sirolimus
Burkitt Lymphom… Leukemia Leukemia, Lymph… Lymphoma Precursor Cell … ALL Burkitt's Lymph… CML Lymphoblastic L…
-
-
NCT03381859
Details
2020-04-20
Interventional
40 
Elbasvir-grazop… Grazoprevir
Communicable Di… Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Infections Hepatitis C Vir…
HCV treatment expansion occurred in Egypt
-
NCT01998828
2013-004105-11
Details
2020-04-20
Interventional
239 
N-(cyanomethyl)…
Polycythemia Polycythemia Ve… Thrombocythemia… Thrombocytosis Essential Throm…
-
-
NCT02265510
Details
2020-04-17
Interventional
1/283 
Azacitidine Bortezomib Dexamethasone Gemcitabine Lenalidomide Paclitaxel Pomalidomide
Neoplasms Advanced Malign… Metastatic Canc… Solid Tumors
-
-
NCT02020278
Details
2020-04-17
Interventional
33 
Tolvaptan
Hyponatremia
Issues with recruitment and enrollment made the trial impossible or highly impracticable. Termination of this trial was not due to safety reasons.
This trial was prematurely terminated due to challenges in enrollment. The trial was not terminated due to safety reasons. Due to early termination of the study, no efficacy data were collected.