Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01774578
Details
2020-05-28
Interventional
2/3135 
Docetaxel Gemcitabine Pemetrexed
Carcinoma, Non-… Lung Neoplasms Non-small Cell … Non-small Cell … Progression of …
-
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NCT00614601
Details
2020-05-28
Interventional
29 
Vaccines
Pancreatic Neop… Pancreatic Canc…
Sponsor proceeded with a phase III study for same indication.
-
NCT03565406
Details
2020-05-21
Interventional
111 
Ipilimumab Mocetinostat Nivolumab
Melanoma
recruiting or enrolling participants has halted prematurely and will not resume; participants are no longer being examined or treated
-
NCT03361228
Details
2020-05-21
Interventional
1/25 
Pembrolizumab
Neoplasms Solid Tumors
Study was terminated early based on emerging data with epacadostat and pembrolizumab.
-
NCT02321319
Details
2020-05-21
Interventional
35 
Hydromorphone
Chronic Pain
Business decision - product discontinued
-
NCT03580382
Details
2020-05-20
Interventional
1/23 
Antibodies Trametinib
Melanoma
Per regulatory coordinator, the sponsor is no longer supporting the study.
-
NCT03506620
Details
2020-05-20
Interventional
40 
Ropivacaine
Femoracetabular… Femoroacetabula…
Unforeseen cost restrictions of the drug halted the execution of this study altogether.
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NCT02017600
Details
2020-05-20
Interventional
248 
Fluorouracil
Carcinoma Carcinoma, Squa… Esophageal Neop… Esophageal Squa… Localized Squam…
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NCT04066790
Details
2020-05-19
Interventional
212 
Paclitaxel Trastuzumab
Breast Neoplasm… Breast Cancer
We terminated this trial and initiated a new one including pertuzumab.
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NCT03150420
Details
2020-05-19
Interventional
329 
Sodium thiosulf…
Calciphylaxis
Inability to accrue subjects that met the exclusion criterion "Any prior (within the past 30 days) or current Sodium Thiosulfate treatment".
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NCT02624986
2015-002100-83
Details
2020-05-18
Interventional
1/225 
Obinutuzumab Rituximab
Lymphoma Lymphoma, Folli… Lymphoma, Large… Non-Hodgkin's L…
Sponsor's decision to terminate the study after Phase 1; will not proceed with Phase 2.
Due to the overall modest benefit achieved with the maximum tolerated dose during the dose escalation phase, the Sponsor decided not to open the expansion phase and terminated the study. Consequently, some planned analyses could not be performed.
NCT02909257
Details
2020-05-14
Interventional
4
[10 Refs]
31 
Bupivacaine
Knee Injuries Osteoarthritis,…
inadequate methodology to determine primary outcome
-
NCT01570361
Details
2020-05-14
Interventional
4255 
Anti-Arrhythmia…
Atrial Fibrilla…
The sponsor decided to terminate the study early due to enrolment not proceeding in accordance with expectations, independently from the study outcome.
As the study was terminated early without having met primary effectiveness or futility criteria, the study results should be interpreted with caution.
NCT01318590
Details
2020-05-13
Interventional
32 
Bupivacaine Triamcinolone Triamcinolone A… Triamcinolone d… Triamcinolone h…
Pancreatitis Pancreatitis, C…
Closed by CHUM REB for incomplete documentation of research activities.
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NCT02282904
Details
2020-05-12
Interventional
1/27 
Busulfan Cyclophosphamid… Fludarabine Sirolimus
Granuloma Granulomatous D… Chronic Granulo…
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NCT00303719
Details
2020-05-12
Interventional
2342 
Antilymphocyte … Cyclophosphamid… Cyclosporine Cyclosporins Fludarabine Mycophenolic Ac…
Kidney Neoplasm… Multiple Myelom… Myelodysplastic… Neoplasms, Plas… Plasmacytoma Kidney Cancer Leukemia Lymphoma Plasma Cell Neo…
IRB Study Closure
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NCT02906696
Details
2020-05-11
Interventional
28 
Bosutinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo… Blasts Under 15… Blasts Under 15… Blasts Under 30… Blasts Under 30… Chronic Phase C…
Terminated per PI's request due to competing priorities.
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NCT03053063
2016-004148-13
Details
2020-05-07
Interventional
3
[8 Refs]
883 
Selonsertib
Fatty Liver Non-alcoholic F… Nonalcoholic St…
This study was terminated early due to lack of efficacy based on the results of the Week 48 analysis as prespecified in the clinical study protocol.
Based on the results of the Week 48 analysis, the study was terminated early for lack of efficacy as prespecified in the clinical study protocol.
NCT02061774
Details
2020-05-06
Interventional
421 
Acetaminophen
Low Back Pain
Preliminary analysis showed not clinically significant. Study ended and closed 1/11/2018
Early Termination due to preliminary analysis showed not clinically significant
NCT02385669
Details
2020-05-05
Interventional
1/23 
Ipilimumab
Melanoma
why study stopped
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