Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03537547
Details
2020-06-05
Interventional
46 
Antidepressive … Antipsychotic A… Psychotropic Dr…
Depression Depressive Diso… Depressive Diso… Depression, Uni… Depressive Epis… Major Depressiv…
Per sponsor and PI institution discussions
-
NCT02573857
Details
2020-06-05
Interventional
1/216 
Artefenomel
Malaria
-
-
NCT04347512
Details
2020-06-04
Interventional
30 
Azithromycin Hydroxychloroqu…
COVID-19 Sars-CoV-2, Com…
In view of the notices concerning hydroxychloroquine issued by the regulatory authorities, we withdraw the protocol
-
NCT04001231
Details
2020-06-04
Interventional
10 
Exenatide
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
The study is stopped based upon strategic considerations impacting the clinical development of exenatide once-weekly suspension in China
-
NCT03115320
2016-003959-29
Details
2020-06-04
Interventional
462 
Chorionic Gonad…
Infertility
High cancellation rate in LH test group in interim analysis
-
NCT00958139
Details
2020-06-04
Interventional
361 
Permethrin
Lyme Disease
After year 1, there was insufficient statistical power to detect a difference in the primary outcome measure during planned study period.
-
NCT04184518
2019-001045-40
Details
2020-06-02
Interventional
20 
Cediranib Durvalumab
Melanoma Uveal Neoplasms Metastatic Canc… Uveal Melanoma
The Cediranib producer laboratory decided to stop the development of this product.
-
NCT03718143
Details
2020-06-02
Interventional
26 
Adavosertib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Preleukemia Primary Myelofi… Syndrome Acute Myeloid L… Myelofibroses
Safety concerns
-
NCT03411473
Details
2020-06-02
Interventional
22 
Pembrolizumab
Carcinoma, Non-… NSCLC Stage IV
Trial will not proceed due to changes in the treatment landscape.
-
NCT02842125
Details
2020-06-02
Interventional
1/24 
Capecitabine Nivolumab Pembrolizumab
Recurrence Metastatic Soli… Recurrent Head …
Arm C rolled into parallel study; Arms A and B halted for greater efficacy in Arm C
-
NCT01796470
Details
2020-06-02
Interventional
266 
Idelalisib
Hematologic Neo… Leukemia, Lymph… Lymphoma Lymphoma, Large… Lymphoma, Mantl… Chronic Lymphoc… Diffuse Large B… Indolent Non-Ho… Mantle Cell Lym…
Study was terminated due to safety measures.
As a result of the early termination of the trial for safety, the efficacy endpoints were not evaluable due to insufficient treatment exposure.
NCT00288522
2004-003937-14
Details
2020-06-02
Interventional
25 
Lanreotide
Eye Diseases Graves Ophthalm… Thyroid Disease… Thyroid-Associa…
-
-
NCT04114630
2019-001820-36
Details
2020-06-01
Interventional
30 
Erenumab
Migraine Disord… Migraine
No patients were enrolled and global prioritization of pipeline and research strategy
-
NCT00896025
Details
2020-06-01
Interventional
4255 
Acetylcysteine N-monoacetylcys…
Hepatic Insuffi… Liver Failure Liver Failure, … Acute Liver Fai… Fulminant Hepat…
This observational study was stopped after 140 patients were enrolled, no more funds available to continue.
Early termination lead to zero subjects analyzed.
NCT03050398
Details
2020-05-28
Interventional
38 
Letrozole
Breast Neoplasm… Breast Cancer
GCP issues.
-
NCT02648711
Details
2020-05-28
Interventional
141 
Bevacizumab Leucovorin Oxaliplatin
Neoplasms Solid Tumors
Company decision
-
NCT02405585
Details
2020-05-28
Interventional
210 
Fluorouracil Gemcitabine Irinotecan Leucovorin Oxaliplatin
Pancreatic Neop… Pancreatic Canc… Pancreatic Carc…
-
-
NCT02389985
Details
2020-05-28
Interventional
1/230 
Paclitaxel
Ovarian Cancer
Company decision
-
NCT01836432
Details
2020-05-28
Interventional
3302 
Albumin-Bound P… Capecitabine Fluorouracil Folfirinox Gemcitabine Irinotecan Leucovorin Oxaliplatin Paclitaxel
Neoplasms Pancreatic Neop… Locally Advance… Pancreatic Canc… Pancreatic Carc…
Company decision
-
NCT01826448
Details
2020-05-28
Interventional
113 
Vemurafenib
Melanoma Stage III or St… V600-mutated BR… V600-mutated BR…
No activity was observed. BRAFi-naïve participants should have received triple combination treatment (including MEK inhibitor). Continuation was not justified.
This study was terminated due to business decision before the planned sample size was reached; therefore, the planned outcome measure cannot be evaluated.