Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03474263
Details
2020-06-24
Interventional
20 
Antibodies Antibodies, Mon…
Amyotrophic Lat… Motor Neuron Di… Sclerosis
seeking research grant support
-
NCT03051698
Details
2020-06-24
Interventional
437 
Anti-Bacterial … Ciprofloxacin Complement C1 I… Metronidazole Vancomycin
Angioedemas, He… Asthma
Interim analysis showed no differences between groups
-
NCT04140591
Details
2020-06-23
Interventional
2/310 
Propranolol Proton Pump Inh…
Fibrosis Liver Cirrhosis Peptic Ulcer Ulcer
1. Most patients with liver cirrhosis already use PPI and NSBB 2. 90 % Peptic ulcer size is smaller than 5cm
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NCT04363203
Details
2020-06-22
Interventional
3-
Azithromycin Hydroxychloroqu…
COVID-19 SARS-CoV-2
concerns related to study drug
-
NCT04283136
Details
2020-06-22
Interventional
10 
Padsevonil
Epilepsy Healthy Partici…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures
-
NCT04361552
Details
2020-06-18
Interventional
30 
Immunoglobulin … Immunoglobulins
COVID-19 Coronary Artery… Cytokine Releas… Infections Kidney Failure,… Lung Diseases, … Pulmonary Disea… Stroke Cerebrovascular… Chronic Obstruc… Chronic Renal F… Diabetes Mellit… Malignant Neopl… SARS Coronaviru…
Study abandoned due to drug billing issues
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NCT02419105
Details
2020-06-18
Interventional
391 
Cholecalciferol Testosterone Vitamin D
Hypogonadism Pre-frail Senio…
Delayed recruitment mainly due to a screening to inclusion rate much lower than expected. Due to the delayed recruitment IMP reached the end of its shelf life.
-
NCT00000276
Details
2020-06-18
Interventional
1-
Bupropion
Cocaine-Related…
-
-
NCT03588806
Details
2020-06-17
Interventional
411 
Oxycodone
Chronic Pain Deglutition Dis… Deglutition Opioid Use
Study halted permanently and will not resume; participants are no longer being examined or receiving intervention.
-
NCT01439867
2011-004618-40
Details
2020-06-17
Interventional
218 
Cinacalcet
Hyperparathyroi… Hyperparathyroi… Kidney Diseases Neoplasm Metast… Renal Insuffici… Chronic Kidney …
Amgen decided to terminate the study early to be able to meet US regulatory timelines fo filing. Subjects in treatment were rolled over to the 20140159 study.
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NCT04434378
Details
2020-06-16
Interventional
4170 
Tamsulosin
Hernia Hernia, Inguina… Urinary Retenti… Post Operative …
Significant difference not reached on interim analysis
-
NCT04285268
Details
2020-06-16
Interventional
20 
Antibodies Antibodies, Mon… Antineoplastic … Bortezomib Immunoglobulins Rituximab Venetoclax
Burkitt Lymphom… Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Recurrence High Grade B-Ce… Recurrent Burki… Recurrent Diffu… Recurrent High … Refractory Burk… Refractory Diff… Refractory High…
funding available
-
NCT03908944
Details
2020-06-12
Interventional
20 
Methadone
Headache Pain, Postopera… Postoperative P…
PI- Dr. Jellish passed away. The study was terminated with the IRB
-
NCT04149444
Details
2020-06-11
Interventional
20 
Trifluridine
Breast Neoplasm… Triple Negative… Metastatic Trip…
Sponsor withdrew support
-
NCT03318757
Details
2020-06-11
Interventional
40 
Bupivacaine
Orthognathic Su…
The research could not be conducted as it was denied by the IRB.
-
NCT02056301
Details
2020-06-11
Interventional
462 
Hydromorphone Morphine
Funnel Chest Pectus Excavatu…
New method of pain control pushed by surgeons.
-
NCT04203511
Details
2020-06-09
Interventional
30 
Carboplatin Etoposide Paclitaxel Pemetrexed
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Sponsor Strategic/Business Decision
-
NCT03349840
Details
2020-06-09
Interventional
4273 
Insulin Insulin Glargin… Insulin, Globin…
Diabetes Mellit… Type2 Diabetes
The study was terminated by the IRB and the Institutional Official after the MOPH and WCMQ audits
-
NCT03002012
Details
2020-06-09
Interventional
3
[1 Refs]
22 
Fluconazole Sertraline
AIDS-Related Op… Communicable Di… Cryptococcosis Infections Opportunistic I… Cryptococcal In…
SAEs with n=1 serotonin syndrome, n=2 SAEs after sertraline interruption.
Trial was terminated early by the NIAID DSMB for excess harm.
NCT02872935
Details
2020-06-09
Interventional
422 
Glycopyrrolate
Nausea Vomiting
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