Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01832727
2013-001169-18
Details
2020-07-13
Interventional
1/2
[1 Refs]
65 
Dexamethasone
Multiple Myelom… Neoplasms, Plas…
Enrollment halted during phase 2 to reformulate the investigational product
-
NCT01550510
Details
2020-07-13
Interventional
1/24 
Ascorbic Acid Camptothecin Irinotecan
Colorectal Neop… Stage IV Colore…
Closed: low enrollment, many treatment options available for Colorectal Cancer
-
NCT03003728
Details
2020-07-10
Interventional
20 
Elotuzumab Melphalan
Multiple Myelom… Neoplasms, Plas…
Withdrawal of study support
-
NCT03628053
Details
2020-07-09
Interventional
30 
Blinatumomab Inotuzumab Ozog… Tisagenlecleuce…
Leukemia Leukemia, Lymph… Precursor Cell … Acute Lymphobla…
Novartis is no longer pursuing this study because of planned investigation of novel CAR-T therapies in this patient population.
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NCT04271839
Details
2020-07-07
Interventional
40 
Fluticasone Formoterol Fuma…
Asthma Persistent Asth…
The trial has been terminated early due to the SARS-CoV-2 pandemic.
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NCT04236453
2019-002245-37
Details
2020-07-07
Interventional
116 
Cobicistat Cobicistat mixt… Darunavir Emtricitabine Emtricitabine t… Emtricitabine, … Tenofovir
Healthy
COVID-19 pandemic impacted the BE assessment of the trial. The clinical team decided to terminate the trial in order to start a new pivotal BE trial
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NCT03925155
Details
2020-07-07
Interventional
3
[1 Refs]
0 
Chlorhexidine Iodine
Cesarean Sectio…
The study was withdrawn from the IRB
-
NCT03492710
Details
2020-07-07
Interventional
30 
Antibodies Immunoglobulins Immunoglobulins…
Immunologic Def… Primary Immunod… Primary Immune …
A change in sponsor's developmental strategy
-
NCT03010423
Details
2020-07-07
Interventional
48 
Nicorandil
Coronary Artery… Coronary Diseas… Myocardial Isch… Non-obstructive…
The study was terminated early, due to the lack of approval of data exportation from the Office of Human Genetic Resource Administration (OHGRA) China.
The study was terminated early and due to the lack of approval of data exportation from the Office of Human Genetic Resource Administration (OHGRA) China, the data could not be extracted. Therefore, no data available for the analyses.
NCT02169284
Details
2020-07-07
Interventional
250 
Erlotinib Hydro…
Carcinoma Urinary Bladder… Bladder Carcino… Recurrent Bladd…
-
-
NCT02708849
Details
2020-07-02
Interventional
13 
Ketamine Lamotrigine
Mental Disorder…
-
-
NCT03471559
Details
2020-07-01
Interventional
18 
Cannabidiol
Pharmacokinetic…
Two step study, step two was not feasible based on results from phase one.
-
NCT03043274
Details
2020-06-30
Interventional
423 
Cangrelor
Infarction Myocardial Infa… ST Elevation My… STEMI - ST Elev…
-
The study was terminated because of slow recruitment.
NCT02561897
Details
2020-06-30
Interventional
45 
Edoxaban Warfarin
Atrial Fibrilla…
Did not meet enrolment target for phase 1
-
NCT03053050
2016-004374-18
Details
2020-06-29
Interventional
3
[7 Refs]
808 
Selonsertib
Fatty Liver Non-alcoholic F… Nonalcoholic St…
This study was terminated early due to lack of efficacy based on the results of the Week 48 analysis as prespecified in the clinical study protocol.
Based on the results of the Week 48 analysis, the study was terminated early for lack of efficacy as prespecified in the clinical study protocol.
NCT02138838
2013-004958-18
Details
2020-06-29
Interventional
355 
Cinacalcet
Hyperparathyroi… Hyperparathyroi… Kidney Diseases Neoplasm Metast… Renal Insuffici… Chronic Kidney …
Amgen decided to terminate the study early to be able to meet US regulatory timelines fo filing. Subjects in treatment were rolled over to the 20140159 study.
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NCT04329403
Details
2020-06-26
Interventional
30 
Adapalene
Acne Vulgaris
Market reasons
-
NCT04231682
Details
2020-06-26
Interventional
20 
Denosumab
Osteoporosis
Grant support was withdrawn from Amgen Pharmaceuticals
-
NCT03891979
Details
2020-06-26
Interventional
40 
Ciprofloxacin Metronidazole Pembrolizumab
Adenocarcinoma Pancreatic Canc…
Suspended due to Primary Investigator's decision
-
NCT03827473
Details
2020-06-25
Interventional
21 
Abiraterone Ace… Androgen Antago… Androgens Ascorbic Acid Cortisone Docetaxel Estrogens, Conj… Hormones Methyltestoster… Prednisone
Hypersensitivit… Prostatic Neopl… Castration-Sens… Metastatic Pros… Stage IV Prosta… Stage IVA Prost… Stage IVB Prost…
The trial was closed because the changing standard of care landscape, making this trial not impactful anymore.
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