Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT05169944
Details
2024-02-22
Interventional
1-
Magrolimab
Brain Neoplasms Neoplasms Recurrence Brain Cancer Brain Tumor Adu… Brain Tumor, Pe… Malignant Brain… Progressive Mal… Recurrent Brain…
FDA Partial Clinical Hold
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NCT04845035
Details
2024-02-22
Interventional
20 
Cytarabine Dasatinib Methotrexate Ponatinib
Leukemia Leukemia, Lymph… Philadelphia Ch… Precursor Cell … Acute Lymphobla…
The PI plans to revise the study design in a new protocol
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NCT04780464
2021-000125-27
Details
2024-02-22
Interventional
314 
Cyclophosphamid… Doxorubicin Liposomal doxor… Prednisolone Prednisone
Sarcoma Advanced Soft-t…
Withdrawal grant provider
-
NCT03901573
Details
2024-02-22
Interventional
1/231 
Atezolizumab
Carcinoma Carcinoma, Merk… Skin Neoplasms Cutaneous Squam… Melanoma Merkel Cell Car…
Strategic decision by sponsor
-
NCT03461952
Details
2024-02-22
Interventional
24 
Ipilimumab Nivolumab
Advanced Solid …
cfDNA screening data found that the prevalence of POLE/POLD1 mutations was lower than expected. It was determined that there are no feasible options to amend this study in a fashion that would not be duplicative of other currently accruing trials.
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NCT02865928
Details
2024-02-22
Interventional
442 
Bupivacaine
Pain, Postopera… Augmentation Mastopexy Outpatient Brea… Revision
We decided to terminate this study due to staffing changes and other limitations posed by the COVID-19 pandemic.
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NCT02721888
Details
2024-02-22
Interventional
4127 
Liraglutide
Diabetes Mellit… Fatty Liver Type 2 Diabetes
Failure of inclusion
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NCT05647447
Details
2024-02-21
Interventional
10 
SR 142801
Adenocarcinoma Hot Flashes Prostate Adenoc…
Development of the drug program has been discontinued
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NCT05607342
Details
2024-02-21
Interventional
11 
SR 142801
Adenocarcinoma Prostate Adenoc…
Development of the drug program has been discontinued
-
NCT04624113
Details
2024-02-21
Interventional
113 
Pembrolizumab
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
Ipsen bought out Epizyme
-
NCT04491136
Details
2024-02-21
Interventional
4201 
Sacubitril and …
Arrhythmias, Ca… Heart Failure
Company decision
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NCT04095689
Details
2024-02-21
Interventional
2-
Docetaxel Pembrolizumab
Breast Neoplasm… Triple Negative… Anthracycline-r… Triple Negative…
Stopping rules met per protocol, comprehensive review needed prior to enrolling again
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NCT03374670
Details
2024-02-21
Interventional
20 
Aflibercept
Polypoidal Chor… Vascular Diseas… Idiopathic Poly…
No patients were enrolled. Study terminated for portfolio reasons.
-
NCT05934942
Details
2024-02-20
Interventional
129 
Drospirenone an…
Healthy
Company decision
-
NCT05579977
2022-002834-15
Details
2024-02-20
Interventional
2902 
Semaglutide
Diabetes Mellit… Obesity
The decision to terminate clinical development of PF-07081532 is based on pharmacokinetic data from Phase 1 drug-drug-interaction studies and laboratory measurements of elevated transaminases in these Phase 1 studies as well as a Phase 2 study.
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NCT05168865
Details
2024-02-20
Interventional
40 
Estradiol Letrozole Progesterone
Abortion, Spont… Ovarian Disease… Polycystic Ovar… Frozen Embryo T… Hormone Replace… Letrozole Live Birth Miscarriage Polycystic Ovar…
unexpected slow recruitment and change of center frozen embryo transfer protocol
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NCT05060003
Details
2024-02-20
Interventional
27 
Atezolizumab
Melanoma Stage II Melano…
Sponsor made decision to terminate study.
-
NCT04984577
Details
2024-02-20
Interventional
2-
Edaravone
Cerebral Infarc… Ischemia Ischemic Stroke Stroke Acute Ischemic …
Strategic realignment of sponsors.
-
NCT03997448
Details
2024-02-20
Interventional
23 
Pembrolizumab
Adenocarcinoma Gastroesophagea…
Funder decision
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NCT00456963
Details
2024-02-20
Interventional
4-
Enalapril Losartan
Diabetes Mellit… Hypertension
Because of delay in approval of the protocol by a number of Ethics Commitees the trial was terminated on March 4, 2010. No patient had received any study drug.
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