Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02728323
Details
2020-08-12
Interventional
396 
Levobupivacaine
Pain, Postopera… Pain
Terminated
-
NCT02728310
Details
2020-08-12
Interventional
3
[1 Refs]
96 
Levobupivacaine
Pain, Postopera… Pain
Terminated
-
NCT01868984
Details
2020-08-12
Interventional
210 
Heparin Paclitaxel
Constriction, P… Fistula Fistula Stenosi…
catheters no longer available - difficult to recruit subjects
-
NCT01685658
2015-002381-23
Details
2020-08-12
Interventional
40 
Acetaminophen Ketoprofen
Colic Emergencies Renal Colic Acute Renal Col…
same study already published
-
NCT03035253
Details
2020-08-11
Interventional
116 
Antibodies, Bis…
Colorectal Neop… Metastatic Colo…
-
-
NCT01225172
Details
2020-08-11
Interventional
277 
Letrozole
Breast Neoplasm… Breast Cancer
Business objectives have changed.
-
NCT03449524
Details
2020-08-10
Interventional
269 
CXA-10
Hypertension Pulmonary Arter… PAH
LOE
-
NCT04327401
Details
2020-08-07
Interventional
3299 
Dexamethasone
Acute Lung Inju… Coronavirus Inf… Pneumonia, Vira… Respiratory Dis… Respiratory Dis… Acute Respirato… Coronavirus Inf…
The Data Monitoring Committee recommended to stop the trial based on the Recovery Trial results, which was accepted by the CoDEX Steering Committee.
-
NCT02566889
2015-001653-32
Details
2020-08-06
Interventional
453 
Infliximab
Inflammatory Bo… Intestinal Dise…
Study was terminated due to the inability to enroll a sufficient number of the required subject population
Study was terminated due to the inability to enroll a sufficient number of the required participants.
NCT01341730
Details
2020-08-06
Interventional
441 
Atorvastatin Pioglitazone
Atherosclerosis Carotid Artery … Coronary Artery…
-
-
NCT03587129
Details
2020-08-05
Interventional
2
[15 Refs]
1 
Apatinib
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
No patient enter this study.
-
NCT03006562
Details
2020-08-05
Interventional
4
[1 Refs]
501 
Heparin
Embolism Lymphocele Pulmonary Embol… Thromboembolism Thrombosis Venous Thromboe… Venous Thrombos… Deep Venous Thr… Lymphocele Afte… Prostate Cancer
Early stopping point based on 2nd interim analysis (planned per protocol)
The study met a futility end point at the 2nd interim analysis (pre-planned in the study protocol) leading to an appropriate decision for early closure and termination rather than continuing to planned enrollment of N=666.
NCT03469258
Details
2020-08-03
Interventional
24 
Pancreatin Pancrelipase
Adenocarcinoma Pancreatic Neop… Pancreatic Canc…
Sponsorship for trial was halted after company acquisition
Early termination per sponsor leading to small numbers of subjects enrolled. Those subjects who were enrolled did not meet pathologic criteria to remain on study and would have been replaced had the study continued.
NCT01677572
2012-000349-10
Details
2020-08-03
Interventional
1197 
Immunoglobulin …
Alzheimer Disea… Alzheimer's Dis…
Study was discontinued based on futility analysis conducted on Phase 3 trials (NCT02477800 and NCT02484547) and not based on safety concerns.
-
NCT04412252
Details
2020-07-31
Interventional
20 
Tofacitinib
COVID-19 Pneumonia
Due to the pursuit of other SARS-CoV-2-related research including alternative trials with tofacitinib, this trial was canceled prior to subject enrollment.
-
NCT04329611
Details
2020-07-31
Interventional
3148 
Hydroxychloroqu…
COVID-19
Enrolment was suspended on 22may2020, after Mehra et al (Lancet 2020) then stopped due to lack of Covid19 cases.
-
NCT03907813
Details
2020-07-31
Interventional
40 
Bupivacaine
Pain, Postopera… Opioid Use
change in design
-
NCT03740945
Details
2020-07-31
Interventional
3
[8 Refs]
0 
Dehydroepiandro…
Atrophy Breast Neoplasm… Vaginal Atrophy…
Business decision to not perform this study.
-
NCT03681951
Details
2020-07-31
Interventional
28 
Pembrolizumab
Pancreatic Neop… Neoplasms, Panc…
The study was terminated following an internal review of the company's current research and development portfolio.
-
NCT03619005
Details
2020-07-31
Interventional
30 
Dehydroepiandro…
Hypokinesia Sexual Dysfunct… Hypoactive Sexu…
Business decision to not continue this study (only few subjects were screened).
-