Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03396861
Details
2020-08-21
Interventional
11 
Aflibercept
Macular Edema Irvine-Gass Syn…
Low enrollment
-
NCT03000660
Details
2020-08-21
Interventional
13 
Dexamethasone Venetoclax
Amyloidosis Immunoglobulin … AL Amyloidosis
partial clinical hold per FDA
-
NCT04520620
2020-001823-15
Details
2020-08-20
Interventional
40 
Enoxaparin
Sars-CoV2
End of the COVID 19 epidemic in the region and decision to participate in a national study on the same subject (COVI-DOSE).
-
NCT01866917
Details
2020-08-20
Interventional
1/235 
Ropivacaine
Pain
Pharmacy stopped dispensing study medication
Limitations of this study include interim analysis with limited sample size, thus it may result in inadequate power. Early termination due to pharmacist refusal to dispense the experimental Rx (no AEs/SAEs recorded). Only an abstract was written.
NCT01302613
Details
2020-08-20
Interventional
1/20 
Capecitabine Leucovorin Oxaliplatin
Adenocarcinoma Rectal Neoplasm… Stage II Rectal… Stage III Recta…
Drug shortage
-
NCT00914940
Details
2020-08-20
Interventional
241 
Fludarabine Fludarabine pho… Tacrolimus Thiotepa
Graft vs Host D… Leukemia Myelodysplastic… Preleukemia Syndrome Graft Versus Ho…
Did not reach one of the primary endpoints of decreased total acute GVHD
-
NCT00513552
Details
2020-08-20
Interventional
40 
Clarithromycin Clofazimine Rifabutin
Crohn Disease Mycobacterium a… Paratuberculosi… Crohn's Disease
No patient
-
NCT04398290
Details
2020-08-19
Interventional
20 
Nitric Oxide
COVID-19 Hypoxia Respiratory Ins… Hypoxemia Hypoxemic Respi…
IRB AND FDA REVIEWS DEFERRED
-
NCT04360759
Details
2020-08-18
Interventional
30 
Chloroquine Hydroxychloroqu…
COVID-19 Covid-19 HIV
Equipoise for hydroxychloquine was lost
-
NCT04273191
Details
2020-08-18
Interventional
40 
Brexanolone
Depression Depression, Pos… Depressive Diso… Postpartum Depr…
Sage Therapeutics has decided not to proceed with this study at this time
-
NCT03679975
Details
2020-08-18
Interventional
29 
Riluzole
Amyotrophic Lat… Motor Neuron Di… Sclerosis
The study is no longer required
-
NCT02326844
Details
2020-08-18
Interventional
23 
Talazoparib
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Study was closed by the Cancer Therapy Evaluation Program (CTEP)
-
NCT00789464
Details
2020-08-18
Interventional
20 
Sulfamethoxazol… Trimethoprim
Communicable Di… Infections Urinary Tract I… Recurrent Urina…
Withdrawn by PI
-
NCT00006472
Details
2020-08-18
Interventional
24 
Carboplatin Fluorouracil Paclitaxel
Esophageal Neop… Esophageal Canc…
-
-
NCT03488810
Details
2020-08-17
Interventional
30 
Androgen Antago… Androgens Hormones Nonsteroidal An…
Prostatic Neopl… Prostate Cancer
Extended study timelines and additional budget could no longer be supported.
-
NCT03413891
Details
2020-08-17
Interventional
4222 
Tranexamic Acid
Hemorrhage Tooth Extractio…
Advice from DSMB
-
NCT00825123
Details
2020-08-17
Interventional
42 
Metoprolol
Central Arteria…
-
-
NCT02875067
Details
2020-08-14
Interventional
1/26 
Lenalidomide Pembrolizumab
Hodgkin Disease Lymphoma Relapsed Hodgki… Relapsed Non-Ho…
Merck's decision for early termination of the data
-
NCT00330668
2019-000844-81
Details
2020-08-14
Interventional
3114 
Mecasermin
Failure to Thri… Growth Disorder…
Unacceptable frequency of hypoglycemia observed at and above 200 ug/kg/day
The study was terminated by the sponsor due to an unacceptably high incidence of hypoglycaemia observed in approximately 50% of the subjects receiving 200 μg/kg rhIGF-1 or greater QD.
NCT03598816
Details
2020-08-13
Interventional
20 
Durvalumab Tremelimumab
Carcinoma Carcinoma, Rena… Renal Cell Carc…
FDA Contingencies unresolved
-