Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03241810
2017-000565-76
Details
2020-09-02
Interventional
222 
Fulvestrant
Breast Neoplasm… Metastatic Brea…
Merrimack Inc. terminated the trial early due to business decision
Sponsor (Merrimack Pharmaceuticals, INC.) terminated the trial early due to business decision
NCT03225924
Details
2020-09-02
Interventional
1/225 
Cyclophosphamid… Doxorubicin Prednisone Rituximab Vincristine
DLBCL
Stop of drug development
-
NCT03106571
Details
2020-09-01
Interventional
119 
Methamphetamine
Methamphetamine…
Deemed unable to enroll targeted participants in part due to COVID-19 shut downs
-
NCT01731691
Details
2020-08-31
Interventional
2/3
[1 Refs]
12 
Alpha 1-Antitry… Protease Inhibi…
Acquired Immuno… HIV Infections HIV Disease
Blinded review of the data suggested no significant diferences in outcomes.
Early termination leading to small numbers of subjects analyzed; Technical problems with measurement leading to unreliable or uninterpretable data.
NCT04351919
Details
2020-08-28
Interventional
40 
Azithromycin Hydroxychloroqu…
COVID-19 Patients With C…
- Interest in the use of HCQ is controversial.
-
NCT04349228
Details
2020-08-28
Interventional
30 
Hydroxychloroqu…
COVID-19 COVID19 Healthcare Work… Hydroxychloroqu… Prophylaxis Sars-CoV2
- Interest in the use of HCQ is controversial.
-
NCT04528927
Details
2020-08-27
Interventional
30 
Azithromycin Doxycycline
COVID-19 Respiratory Ins… COVID 19 Patients Hospit…
- Interest in the use of HCQ is controversial.
-
NCT03213626
Details
2020-08-27
Interventional
27 
Erlotinib Hydro…
Adenocarcinoma Pancreatic Aden…
There were no objective responses by patient 7.
-
NCT02346955
Details
2020-08-27
Interventional
127 
Pembrolizumab
Carcinoma, Non-… Bladder Cancer Colorectal Canc… Gastric Cancer Melanoma Non-small Cell … Ovarian Cancer
-
-
NCT01535157
NCT01550692
Details
2020-08-27
Interventional
1/212 
Fenretinide Ketoconazole Retinamide
Carcinoma Carcinoma, Ovar… Ovarian Neoplas… Cancer of Ovary Cancer of the O… Ovarian Cancer Ovary Neoplasms Primary Periton…
drug combination not providing any efficacy. Will use this data in opening new trial
-
NCT04053543
Details
2020-08-26
Interventional
233 
CXA-10
Hypertension Pulmonary Arter… PAH
LOE
-
NCT03351231
2017-003603-21
Details
2020-08-26
Interventional
1/27 
Nivolumab
Cancer
Inability to meet protocol objectives
-
NCT03232632
Details
2020-08-26
Interventional
17 
Flutemetamol
Amyloidosis Cardiac Amyloid…
intervention programming
-
NCT02971839
Details
2020-08-26
Interventional
211 
Ivacaftor
Cystic Fibrosis Fibrosis
Decision by Sponsor.
-
NCT02591199
Details
2020-08-26
Interventional
292 
Heparin Lidocaine
Cystitis Cystitis, Inter… Somatoform Diso… Syndrome Bladder Pain Sy… Interstitial Cy…
Prematurely terminated based on interim study analysis
-
NCT02558023
Details
2020-08-25
Interventional
314 
Nicardipine Urapidil
Hypertension Pre-Eclampsia Preeclampsia
no candidats
-
NCT00859495
Details
2020-08-25
Interventional
29 
Doxorubicin Pemetrexed
Mesothelioma Mesothelioma, M… Pleural Mesothe…
-
Study was terminated early due to the retirement of the study physician responsible for the P-32 radiotherapy, and the need for further funding.
NCT03498196
Details
2020-08-24
Interventional
1/21 
Avelumab
Urinary Bladder… Bladder Cancer Invasive Bladde… Metastatic Blad…
The sponsor of this study has terminated the study due to poor enrollment.
-
NCT01038856
Details
2020-08-24
Interventional
25 
Erlotinib Hydro…
Polycythemia Polycythemia Ve…
The study was terminated by the sponsor
-
NCT00443963
Details
2020-08-24
Interventional
40 
Esomeprazole Ranitidine
Dyspepsia
The study was not approved by the Human Studies Subcommittee.
-