Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02905981
Details
2020-09-22
Interventional
21 
Citric Acid Sodium Citrate
Anemia Anemia, Iron-De… Deficiency Dise… Iron Deficienci… Iron-Refractory…
Limited subjects, patient compliance
Study terminated after one patient was enrolled. Patient discontinued due to lack of improvement in hemoglobin levels and subject compliance issues. Termination after only one subject enrolled does not allow definitive conclusions to be reached.
NCT02664922
Details
2020-09-22
Interventional
435 
Ketamine Propofol Remifentanil Sevoflurane
Heart Diseases Cardiac Disease
Poor study design and too many study groups.
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NCT02188719
Details
2020-09-22
Interventional
115 
Acetaminophen Anti-Infective … Antilymphocyte … Diphenhydramine Everolimus Ganciclovir Liver Extracts Methylprednisol… Mycophenolic Ac… Prednisone Promethazine Tacrolimus Thymoglobulin Valganciclovir
Liver Transplan…
The trial could not be completed within the grant timeline.
Enrollment was terminated due to several factors:high number of ineligible subjects, slow enrollment, and manufacturing difficulties within the constraints of the funding period.
NCT04220476
Details
2020-09-21
Interventional
20 
Letrozole Palbociclib
Breast Neoplasm… Breast Cancer
Initiating a new study with revised Statistics.
-
NCT01916187
Details
2020-09-21
Interventional
10 
Imetelstat Motesanib dipho…
Neuroblastoma
drug company withdrew support following re-examination of benefit-risk assessment for the investigational use of imetelstat in this population
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NCT00894751
Details
2020-09-21
Interventional
198 
Dexmedetomidine Propofol
Anesthesia Magnetic Resona…
low enrollment and high participant withdraw
-
NCT00167661
Details
2020-09-21
Interventional
1/233 
Alemtuzumab
Disorder Relate…
Enrollment suspended pending protocol revision to change study to observational
-
NCT01915303
Details
2020-09-18
Interventional
268 
Cabergoline Pasireotide
ACTH-Secreting … Pituitary ACTH … Cushings Diseas…
-
-
NCT00539838
Details
2020-09-17
Interventional
333 
Azathioprine Immunosuppressi… Methotrexate Methylprednisol… Mycophenolic Ac… Ocrelizumab Prednisone
Lupus Erythemat… Systemic Lupus …
The study was terminated prematurely when the decision was made that ocrelizumab was not likely to benefit this patient population.
The study was terminated before any patients reached the Week 48 visit. Therefore, the safety analysis included all safety data for the 33 randomized patients that were available up to the data cutoff date (22 March 2010)
NCT04334967
Details
2020-09-16
Interventional
413 
Ascorbic Acid Hydroxychloroqu…
COVID-19 Coronavirus Inf… 2019 Novel Coro… 2019-nCoV Corona Virus In… SARS-CoV-2
suspected unfavorable risk/benefit assessment
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NCT03116971
Details
2020-09-16
Interventional
12 
Etoposide Peposertib
Lung Neoplasms Small Cell Lung… Small Cell Lung…
Enrollment in the study was prematurely terminated due to recruitment challenges and not due to concerns of safety for the participants.
-
NCT02436135
Details
2020-09-16
Interventional
110 
Idelalisib
Polycythemia Polycythemia Ve… Primary Myelofi… Thrombocythemia… Thrombocytosis Myelofibrosis
-
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NCT04440488
Details
2020-09-14
Interventional
40 
Alpha 1-Antitry… Protease Inhibi…
Alpha 1-Antitry… Emphysema Lung Diseases Lung Diseases, … Pulmonary Disea… Alpha1-antitryp… Chronic Obstruc…
Reevaluation of development strategy
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NCT04402580
Details
2020-09-14
Interventional
230 
Mycophenolic Ac… Rituximab
Nephrosis Nephrotic Syndr… Syndrome Nephrotic Syndr…
due to unexpectedly high rate of relapse in the active comparator arm.
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NCT03038477
Details
2020-09-14
Interventional
20 
Durvalumab
Pancreatic Canc…
Cancelled by PI
-
NCT01466855
Details
2020-09-14
Interventional
136 
Topotecan
Retinoblastoma
Competing studies
-
NCT03959852
Details
2020-09-11
Interventional
46 
Fentanyl Ketamine
Acute Pain Pain, Acute
Residency completed.
-
NCT03382912
Details
2020-09-11
Interventional
252 
Nivolumab
Carcinoma, Non-… Lung Neoplasms Non Small Cell …
The CYPRESS-2 trial was closed early after the planned final analysis because the risk benefit ratio is unfavorable.
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NCT03298412
2016-003255-30
Details
2020-09-11
Interventional
210 
Blinatumomab
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Neoplasm, Resid… High-risk Diffu…
Early Closure due to rare patient population
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NCT00625898
Details
2020-09-10
Interventional
33509 
Bevacizumab Carboplatin Cyclophosphamid… Docetaxel Epirubicin Fluorouracil Trastuzumab
Breast Neoplasm… Breast Cancer
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