Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00054210
Details
2020-10-05
Interventional
3-
Albumin-Bound P… Carboplatin Paclitaxel Paclitaxel poli…
Carcinoma, Non-… Lung Neoplasms Lung Cancer
-
-
NCT00054197
Details
2020-10-05
Interventional
3
[1 Refs]
-
Gemcitabine Paclitaxel Paclitaxel poli… Vinorelbine
Carcinoma, Non-… Lung Neoplasms Lung Cancer
-
-
NCT00054184
Details
2020-10-05
Interventional
3-
Docetaxel Paclitaxel Paclitaxel poli…
Carcinoma, Non-… Lung Neoplasms Lung Cancer
-
-
NCT00020969
Details
2020-10-05
Interventional
2
[1 Refs]
-
Arsenic Trioxid…
Leukemia Myelodysplastic… Myelodysplastic… Myeloproliferat… Preleukemia Syndrome Myelodysplastic…
-
-
NCT00017069
Details
2020-10-05
Interventional
2-
Arsenic Trioxid… Dexamethasone
Multiple Myelom… Neoplasms, Plas… Plasmacytoma Multiple Myelom…
-
-
NCT02353780
Details
2020-10-01
Interventional
410 
Abatacept Certolizumab Pe… Etanercept Infliximab Tumor Necrosis …
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Low enrollment
Due to the small number of patients enrolled in each group, it was not possible to perform statistical analyses of the primary endpoints. These are fairly broad measures that require large numbers to identify patterns in subset changes.
NCT04085393
Details
2020-09-30
Interventional
20 
Granisetron
Nausea Vomiting Chemotherapy-in…
sponsor withdrew study
-
NCT02476955
Details
2020-09-30
Interventional
141 
Albumin-Bound P… Anastrozole Carboplatin Paclitaxel
Endometrial Neo… Ovarian Neoplas… Endometrial Can… Ovarian Cancer Solid Tumors
-
-
NCT01942993
Details
2020-09-30
Interventional
23 
Vemurafenib
Melanoma
standard of care has changed
Too few subjects to assess for correlation. Also no subject underwent tissue tumor biopsy which were not mandatory.
NCT01080222
Details
2020-09-30
Interventional
2152 
Peginterferon a… Ribavirin
Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Infections Virus Diseases Chronic Hepatit…
Study discontinued
-
NCT02505087
Details
2020-09-29
Interventional
2/37 
Acetylcysteine N-monoacetylcys…
Genetic Disease… Muscular Diseas… Selenoprotein N…
-
-
NCT02283905
Details
2020-09-29
Interventional
42 
Amphotericin B Liposomal ampho… Voriconazole
Blastomycosis
Poor enrollment numbers of patients
-
NCT01103024
2009-015509-38
Details
2020-09-29
Interventional
30 
Antibodies, Mon…
Uveitis
Core study in non-infectious active uveitis was terminated
-
NCT04116359
Details
2020-09-28
Interventional
1/20 
Cisplatin Etoposide Etoposide phosp… Podophyllotoxin
Carcinoma Metastatic NUT … Unresectable NU…
Other - Protocol moved to Disapproved
-
NCT03925428
Details
2020-09-28
Interventional
10 
Entinostat Histone Deacety…
Carcinoma Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H… Lymphoma, T-Cel… Neoplasms Pancreatic Neop… Advanced Lympho… Advanced Malign… Ann Arbor Stage… Ann Arbor Stage… Ann Arbor Stage… Ann Arbor Stage… Refractory B-Ce… Refractory Lymp… Refractory Mali… Refractory Panc… Refractory T-Ce… Stage II Pancre… Stage IIA Pancr… Stage IIB Pancr… Stage III Pancr… Stage IV Pancre… Unresectable Pa…
Other - Protocol moved to Disapproved
-
NCT03391856
Details
2020-09-25
Interventional
2/315 
Acetylcysteine N-monoacetylcys…
Thrombocytopeni… Stem Cell Trans…
protocol changed
-
NCT01821963
Details
2020-09-24
Interventional
31 
Interferon alph… Interferon-alph… Interferons Peginterferon a… Ribavirin
Carcinoma Carcinoma, Hepa… Communicable Di… Infections Infection
Low referral rate due to new therapeutic options.
-
NCT01697293
Details
2020-09-24
Interventional
1/234 
Albumin-Bound P… Cyclophosphamid… Doxorubicin Liposomal doxor… Paclitaxel
Breast Neoplasm… Breast Adenocar… Estrogen Recept… HER2/Neu Negati… Recurrent Breas… Stage IIB Breas… Stage IIIA Brea… Stage IIIB Brea… Stage IIIC Brea… Stage IV Breast…
criteria for continuing enrollment in Phase 2 portion was not met
-
NCT01690468
Details
2020-09-24
Interventional
1/215 
Carboplatin
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Enrollment stopped prior to Phase 1b, change in strategic focus
-
NCT00506948
Details
2020-09-24
Interventional
213 
Antilymphocyte … Mycophenolic Ac… Sirolimus Thymoglobulin
Hematologic Neo… Myelodysplastic… Neoplasms Preleukemia Hematological M… Leukemia Lymphoma Myelodysplastic…
Halted due to high incidence of veno-oclusive disease of the liver.
A decision to terminate this trial was made due to the high incidence of veno-occlusive disease of the liver in participants receiving this graft-versus-host disease (GVHD) prophylaxis regimen.