Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04333628
Details
2020-10-14
Interventional
2/35 
Chloroquine
COVID-19
Teminated due to changes in treatment guidelines .
-
NCT04212065
Details
2020-10-14
Interventional
40 
Buprenorphine
Opioid-Related … Opioid Use Diso…
closed due to new safety concerns of subcutaneous buprenorphine in pregnant patients
-
NCT04049578
Details
2020-10-14
Interventional
12 
Balovaptan
Autism Spectrum… Autistic Disord… Child Developme…
Recent analysis of Phase II balovaptan data in paediatric ASD did not support the continuation of this study. No new safety concerns were identified.
Study was terminated with 2 participants enrolled. Due to low enrollment number patient analysis are not provided to protect participant confidentiality.
NCT03068754
Details
2020-10-14
Interventional
2/3143 
Adrenocorticotr…
Amyotrophic Lat… Motor Neuron Di… Sclerosis
As recommended by the study's independent Data and Safety Monitoring Board (DSMB)
-
NCT03013127
Details
2020-10-14
Interventional
212 
Pembrolizumab
Osteosarcoma
Inclusion of patients was stopped because ≤2 patients had clinical benefit.
-
NCT02941016
Details
2020-10-14
Interventional
40 
Alirocumab Evolocumab
Inflammation Lipid Lowering,…
Logistic reasons
-
NCT03052517
2016-001560-11
Details
2020-10-12
Interventional
32538 
Indoleacetic Ac…
Asthma
Company Decision
-
NCT03862053
Details
2020-10-09
Interventional
40 
Ophthalmic Solu…
Conjunctivitis Conjunctivitis,… Hypersensitivit… Allergic Conjun…
not enough time to complete trial;covid
-
NCT03106753
Details
2020-10-09
Interventional
434 
Bupivacaine Terbutaline
External Cephal…
Interim analysis to assess concern for spinal anesthesia and increased cesarean delivery rate.
-
NCT02829372
2015-002926-38
Details
2020-10-09
Interventional
136 
Antibodies Antibodies, Bis… Antibodies, Mon…
HER2 Expressing…
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention
-
NCT04342156
Details
2020-10-08
Interventional
30 
Hydroxychloroqu…
COVID-19 Coronavirus Inf… Coronavirus Inf… Hydroxychloroqu…
The number of patients with COVID-19 in Singapore was coming down for the community and the concerns about the potential side effects particularly when the baseline ECG and serum electrolytes was not proposed.
-
NCT04088266
Details
2020-10-08
Interventional
40 
Buprenorphine Naloxone
Evaluation of Q…
Study delayed indefinetly
-
NCT00152308
Details
2020-10-08
Interventional
4-
Ethanol MTOR Inhibitors Sirolimus Temsirolimus
Coronary Diseas…
Slow enrolement
-
NCT04561817
Details
2020-10-06
Interventional
20 
Ipatasertib Paclitaxel
Carcinoma, Ovar… Ovarian Neoplas…
Evolving data with Ipatasertib that changes the known risk / benefit background in pursuing future studies.
-
NCT03107325
Details
2020-10-06
Interventional
4
[1 Refs]
0 
Fluorodeoxygluc…
Neoplasms Childhood Neopl…
No subjects who met the study criteria agreed to participate in two years prior to the COVID-19 crisis.
-
NCT00017433
Details
2020-10-06
Interventional
2-
Arsenic Trioxid…
Multiple Myelom… Neoplasms, Plas… Plasmacytoma Multiple Myelom…
-
-
NCT04575558
Details
2020-10-05
Interventional
20 
Azithromycin Hydroxychloroqu…
Sars-CoV2
Withdrawn due to lack of study centers interested in participating.
-
NCT04206865
Details
2020-10-05
Interventional
40 
Sacubitril and … Valsartan Vasodilator Age…
Cardiac Output,… Shock, Cardioge… Cardiogenic Sho…
New study initiated
-
NCT02253992
2014-002241-22
Details
2020-10-05
Interventional
1/2232 
Nivolumab
Lymphoma, B-Cel… Lymphoma, Non-H… Advanced B-cell… Advanced Solid …
-
-
NCT00551733
2007-004167-22
Details
2020-10-05
Interventional
3
[1 Refs]
-
Albumin-Bound P… Carboplatin Paclitaxel Paclitaxel poli…
Carcinoma, Non-… Lung Neoplasms Lung Cancer
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