Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT01898377
Details
2020-10-23
Interventional
29 
Imatinib Mesyla… Mycophenolic Ac…
Bronchiolitis O… Graft vs Host D… Chronic Graft-v…
New treatment option introduced for patients with the study indication
-
NCT01897714
Details
2020-10-23
Interventional
1/275 
Dexamethasone
Multiple Myelom… Neoplasms, Plas… Relapsed and/or…
The study was terminated at median 46-48 months long term follow-up and mature overall survival follow-up data.
Study is terminated and long-term follow-up ended due to Sponsor decision.
NCT00032773
Details
2020-10-23
Interventional
1/2-
Pentostatin
Graft vs Host D… Acute Graft Ver…
-
-
NCT03043651
Details
2020-10-22
Interventional
348 
Treprostinil
Hypertension Hypertension, P… Pulmonary Hyper…
Terminated by Sponsor
-
NCT02981459
Details
2020-10-22
Interventional
40 
Mirabegron
Cystitis, Inter… Bladder Irritab… Bladder Pain Sy… Urinary Frequen…
Withdrawn by Sponsor
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NCT02953561
Details
2020-10-22
Interventional
1/219 
Antibodies, Mon… Avelumab Azacitidine
Leukemia Leukemia, Myelo… Leukemia, Myelo… Myelodysplastic… Acute Myeloid L… Recurrent Acute… Refractory Acut…
PDOL request
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NCT02781805
Details
2020-10-22
Interventional
16 
Alendronate
Breast Neoplasm…
-
-
NCT02522975
Details
2020-10-22
Interventional
416 
Epoetin Alfa
Anemia Renal Anaemia
-
-
NCT02318368
Details
2020-10-22
Interventional
210 
Erlotinib Hydro…
Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Sponsor's decision
The Sponsor terminated Study AV-299-14-206 before enrollment was completed, effective 14-Sep- 2016, after determining that enrollment of subjects was much lower than expected, and that timely completion of the study was not feasible.
NCT02032173
Details
2020-10-22
Interventional
331 
Ranibizumab
Edema Macular Degener… Macular Edema Diabetes
Study was prematurely discontinued as it was unethical to continue based on a change in ranibizumab (RFB) marketing authorization.
-
NCT00328809
Details
2020-10-22
Interventional
40 
Spironolactone
Heart Failure Kidney Diseases Kidney Failure,… Congestive Hear… End Stage Renal…
personnel shortage
-
NCT03239860
Details
2020-10-20
Interventional
2220 
Antibodies Antibodies, Mon…
Multiple Sclero… Multiple Sclero… Sclerosis
Based on R&D strategic reasons, our co-development Partner financing the study disengaged from the development of GNbAC1.
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NCT04516603
Details
2020-10-19
Interventional
20 
4-Aminopyridine
Working Memory
Changement of study design. Restart spring 2021.
-
NCT03945227
Details
2020-10-19
Interventional
20 
Spartalizumab
Carcinoma, Non-… Stage III NSCLC
Due to the delay in the study shceduled, due to the start of competitive study and the approval of Durvalumab from the Ministry of Food and Drug Safety, it was judged that it was difficult to enroll subjects.
-
NCT03596723
Details
2020-10-19
Interventional
32 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Cataract Inflammation Ocular Inflamma…
NDA #210565 did not trigger the need for a Pediatric Research Equity Act study.
Due to stopping the study after just two subjects were enrolled, no meaningful conclusions could be reached.
NCT02876094
Details
2020-10-19
Interventional
21 
Celecoxib
Atrophy Muscular Atroph… Muscular Atroph… Spinal Muscular…
Terminated: Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention
-
NCT02709889
Details
2020-10-19
Interventional
1/2200 
Dexamethasone Rovalpituzumab …
Carcinoma Carcinoma, Neur… Glioblastoma Melanoma High Grade Gast… Large-Cell Neur… Malignant Melan… Medullary Thyro… Neuroendocrine … Other Neuroendo… Other Solid Tum…
Strategic considerations
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NCT01806064
Details
2020-10-19
Interventional
1/2173 
Axitinib
Carcinoma Carcinoma, Rena… Renal Cell Carc…
The study did not meet endpoint.
The study was terminated early due to lack of efficacy therefore protein biomarkers (P1b and P2), PK (P2), immunogenicity (P2) and disease control rate at 16 weeks by RECIST 1.1 and Choi criteria were not analyzed.
NCT01194960
Details
2020-10-19
Interventional
2
[1 Refs]
25 
Docetaxel
Prostatic Neopl… Hormone Refract…
-
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NCT00622466
Details
2020-10-19
Interventional
220 
Paclitaxel Sorafenib
Breast Neoplasm… Breast Cancer
Study sponsor requested that the study be permanently closed by letter.
-