Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04379492
Details
2020-10-30
Interventional
20 
Hydroxychloroqu…
COVID-19 COVID19 SARS-Cov-2 Sars-CoV2
Emerging evidence does not support the use of HCQ for treatment or prevention of SARS -CoV2 infection. No pts have been enrolled.
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NCT02802514
Details
2020-10-30
Interventional
45 
Exenatide Glucagon-Like P… rGLP-1 protein
Nausea Diabetes Mellit…
-
-
NCT02793154
Details
2020-10-30
Interventional
44 
Exenatide rGLP-1 protein
Diabetes Mellit… Diabetes Mellit…
Early termination due to insufficient enrollment.
-
NCT02757391
Details
2020-10-30
Interventional
11 
Aldesleukin Cyclophosphamid… Immunologic Fac… Immunomodulatin… Interleukin-2 Pembrolizumab
Adenocarcinoma Carcinoma Cholangiocarcin… Colorectal Neop… Esophageal Neop… Stomach Neoplas… Colorectal Aden… Metastatic Chol… Metastatic Colo… Metastatic Dige… Metastatic Esop… Metastatic Gast… Metastatic Panc… Stage IV Colore… Stage IV Esopha… Stage IV Gastri… Stage IV Pancre… Stage IVA Color… Stage IVB Color…
Study halted prematurely and will not resume; participants are no longer being examined or receiving intervention.
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NCT01668654
Details
2020-10-30
Interventional
34 
Ezogabine
Epilepsy Lennox Gastaut …
FDA placed a clinical hold on the Pediatric Program requiring retigabine discontinuation in subjects; early termination allows for timely reporting of results.
This study was terminated early and only 4 of the planned 500 participants were enrolled. Due to the early study termination and small sample size, many planned analyses were not completed therefore lmiited results data were available.
NCT01195779
2010-020312-12
Details
2020-10-30
Interventional
24 
Vaccines
Influenza, Huma… Influenza Influenza Vacci…
The study was terminated for logistic reasons not related to safety or efficacy of the vaccine.
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NCT01114503
2009-016747-19
Details
2020-10-30
Interventional
22 
Methylprednisol… Methylprednisol… Methylprednisol… Prednisolone Prednisolone ac… Prednisolone he… Prednisolone ph…
Eye Diseases Graves Ophthalm…
Clinical study in Graves' ophthalmopathy terminated until there is a better understanding of an efficacious dose with Otelixizumab from other clinical studies.
The study was terminated due to the need of better understanding of an efficacious dose with otelixizumab from other clinical studies.
NCT00206375
Details
2020-10-30
Interventional
416 
Hormones
Hypothyroidism
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NCT04363866
Details
2020-10-29
Interventional
20 
Hydroxychloroqu…
COVID-19 SARS-CoV-2
discontinued in favor of more promising directions that may benefit patients
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NCT04274933
2019-003452-36
Details
2020-10-29
Interventional
14 
Capecitabine Venetoclax
Breast Neoplasm… Disease Progres… Breast Cancer Cancer
Company Decision
-
NCT01987596
Details
2020-10-29
Interventional
323 
Lenograstim
Choroid Plexus … Medulloblastoma Neuroblastoma Neuroectodermal… Neuroectodermal… Osteosarcoma Pinealoma Retinoblastoma Sarcoma Wilms Tumor Childhood Choro… Childhood Medul… Childhood Pineo… Childhood Soft … Childhood Supra… Recurrent/Refra… Unspecified Chi… Wilms Tumor and…
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NCT04088903
Details
2020-10-28
Interventional
10 
Daratumumab
Allosensitizati… Heart Transplan…
Protocol changed to use subcutaneous rather than intravenous daratumumab.
-
NCT01355575
2010-021515-17
2010-021515-17
Details
2020-10-28
Interventional
415 
Rifaximin
Fatty Liver Liver Diseases Non-alcoholic F… NAFLD Nonalcoholic Fa… Nonalcoholic St…
Primary endpoint data review concluded no further patients required.
-
NCT04371406
2020-001702-35
Details
2020-10-27
Interventional
30 
Azithromycin Hydroxychloroqu…
COVID-19 Covid-19
Regulatory approvals have not been obtained
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NCT01673386
Details
2020-10-27
Interventional
258 
Sunitinib Tivozanib
Carcinoma Carcinoma, Rena… Metastatic Rena…
Sponsor
The Sponsor terminated Study AV-951-12-205 before enrollment was completed, following the negative decision of the US FDA.
NCT04344288
2020-001553-48
Details
2020-10-26
Interventional
211 
Prednisone
COVID-19 Pneumonia Pneumonia, Vira… Viral Pneumonia…
Competent Authority's decision
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NCT04231864
Details
2020-10-26
Interventional
20 
Antibodies, Mon… Durvalumab Immunoglobulin … Immunoglobulins
Carcinoma Epstein-Barr Vi… Nasopharyngeal … Recurrence Epstein-Barr Vi… Metastatic Naso… Recurrent Nasop… Stage III Nasop… Stage IV Nasoph… Stage IVA Nasop… Stage IVB Nasop…
Feasibility
-
NCT03526536
Details
2020-10-26
Interventional
440 
Insulin Insulin, Globin…
Insulin Resista… Kidney Failure,… Diabetes Mellit… End-Stage Renal…
The study required more participants than anticipated for statistical significance.
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NCT02418754
NCT02603484
Details
2020-10-26
Interventional
2505 
Aflibercept
Macular Degener… Wet Macular Deg… Neovascular Age…
No additional efficacy seen with REGN2176-3 over aflibercept alone
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NCT02189889
Details
2020-10-23
Interventional
1/25 
Ferrosoferric O…
Anemia Cardiovascular … Cardiovascular …
Initial patients were seen at St Paul Hospital. Enrollment changes occurred with the move to Clements Hospital. We were unable to identify an infusion room at CUH despite an exhaustive search for alternatives and forced to terminate early.
Early termination leading to small numbers of subjects analyzed.