Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04267913
Details
2020-11-20
Interventional
20 
Antibodies Antibodies, Mon… Antineoplastic … BB 1101 Dexamethasone Dexamethasone a… Docetaxel Immunoglobulins Lexatumumab Ramucirumab
Carcinoma Lung Neoplasms Lung Squamous C… Recurrent Lung … Stage IV Lung C… Stage IVA Lung … Stage IVB Lung …
The pharmaceutical company sold the compound and pulled out.
-
NCT01383044
Details
2020-11-20
Interventional
465 
Carvedilol
Hemorrhage Variceal Bleedi…
slow enrollment
-
NCT01096290
Details
2020-11-20
Interventional
423 
Lubiprostone
Constipation
Number of needed participants could not be obtained
100 participants were needed to obtain statistical power. Only 23 participants were enrolled. Therefore, data analysis was not completed since a success rate could not be adequately demonstrated on such a small sample.
NCT04343001
Details
2020-11-19
Interventional
30 
Aspirin Losartan Simvastatin
COVID-19 Covid-19
Grant not obtained
-
NCT03962634
Details
2020-11-19
Interventional
23 
Carticaine Oxymetazoline Tetracaine
Dental Caries Periapical Peri… Periodontitis Apical Periodon… Caries,Dental
Drug is no longer being manufactured
-
NCT03760250
Details
2020-11-19
Interventional
26 
Imiquimod
Keloid Recurrence
Investigator decision
-
NCT03028012
Details
2020-11-18
Interventional
410 
Dexamethasone Ketorolac Lidocaine
Myofascial Pain
Poor enrollment.
Early termination of this study due to low subject enrollment, lack of participant follow-up to substantiated end of study measures. There was not enough reported data to provide statistically pertinent or relevant analysis.
NCT02942485
Details
2020-11-18
Interventional
48 
Metronidazole Tinidazole
Giardiasis GIARDIASIS
Extremely slow enrollment
The study was terminated due to the extremely slow patient enrollment: eight patients only have been referred and recruited during the two-year period. 6/8 patients fulfilled one or more of the exclusion criteria.
NCT04345692
Details
2020-11-17
Interventional
317 
Hydroxychloroqu…
COVID-19
RECOVERY Trial results - no efficacy
-
NCT04262388
Details
2020-11-17
Interventional
20 
Durvalumab
Adenocarcinoma Carcinoma Carcinoma, Non-… Carcinoma, Squa… Lung Neoplasms Squamous Cell C… Non-small Cell … Pancreatic Duct…
Overall clinical activity (ORR) for oleclumab + durvalumab is minimal across tumor types and does not support further evaluation of this doublet.
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NCT04262375
Details
2020-11-17
Interventional
20 
Durvalumab
Carcinoma, Rena… Non Small Cell … Renal Cell Carc…
Overall clinical activity (ORR) for oleclumab + durvalumab is minimal across tumor types and does not support further evaluation of this doublet.
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NCT04138485
2019-000906-31
Details
2020-11-17
Interventional
20 
Immunoglobulins
Scleroderma, Di… Scleroderma, Sy… Sclerosis Diffuse Cutaneo…
Due to business reasons, not safety issues
-
NCT02387164
Details
2020-11-17
Interventional
226 
Cholecalciferol Vitamin D
Diabetes Mellit… Prediabetic Sta…
The study was interrupted early and terminated when only 26 out of 80 patients were enrolled due to new clinical study results indicating that the current study would not be informative.
This study was interrupted early and terminated when only 26 out of 80 patients were enrolled. The patients were followed for 2 years rather than the planned 5 years.
NCT04158830
Details
2020-11-13
Interventional
4
[7 Refs]
0 
Aspirin
Pre-Eclampsia Preeclampsia
PI is no longer at this University.
-
NCT00796107
Details
2020-11-13
Interventional
26 
Letrozole
Breast Neoplasm… Breast Cancer
Due to the discontinuation of compound development, this study has been terminated.
Phase 2 of this study was not conducted.
NCT02897830
Details
2020-11-12
Interventional
246 
Dexamethasone Ixazomib Lenalidomide
Multiple Myelom… Neoplasms, Plas…
negatives results
-
NCT01925378
Details
2020-11-12
Interventional
20 
Nelfinavir
Uterine Cervica… Cervical Dyspla…
The study is going to open in a new site
-
NCT03037580
Details
2020-11-10
Interventional
384 
Treprostinil
Heart Failure Hypertension Hypertension, P… Heart Failure W… Pulmonary Hyper…
Terminated by sponsor
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NCT04183634
Details
2020-11-09
Interventional
131 
Rotigotine
Parkinson Disea…
Company Decision
-
NCT04364815
Details
2020-11-06
Interventional
30 
Hydroxychloroqu…
COVID-19
Investigators opted to change the design of the study.
-