Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00058188
Details
2020-12-08
Interventional
353 
Calcium Cholecalciferol Vitamin D Zoledronic Acid
Osteoporosis Prostatic Neopl… Prostate Cancer
Closed by the research committee
-
NCT02566707
Details
2020-12-07
Interventional
29 
Atazanavir Sulf… Dolutegravir Lamivudine
HIV-1 Infection
due to introduction of another integrase inhibitor, recruitement was not feasible anymore.
-
NCT01607346
2012-002260-26
Details
2020-12-04
Interventional
410 
Ezogabine
Seizures Epilepsy
-
The study was terminated after 10 of 100 subjects had been enrolled. Statistical analyses were not performed as the sample size enrolled was too small to allow for these analyses to be meaningful. The data are presented as summary statistics only.
NCT00673920
Details
2020-12-04
Interventional
3314 
Methotrexate Ocrelizumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Based on analysis of results and consideration of available treatments, the overall benefit to risk profile of ocrelizumab was not favorable in RA.
-
NCT03655444
Details
2020-12-03
Interventional
1/26 
Nivolumab
Carcinoma Carcinoma, Squa… Squamous Cell C… Head and Neck S…
Provider of drug decided to discontinue study.
-
NCT03426995
2017-003997-15
Details
2020-12-02
Interventional
148 
Cantharidin
Arthritis, Rheu…
The trial was terminated for strategic reasons following the emergence of new data.
-
NCT03597022
2017-003324-67
Details
2020-11-30
Interventional
224 
Immunoglobulin … Immunoglobulins Lipoprotein-ass…
Hemophilia A Hemophilia A an…
Due to thrombosis
Acceptable safety and tolerability of befovacimab was not demonstrated in the study, prompting early termination of the study. The "post-hoc" SAP was used for analyses. The other SAP was pre-specified but became not applicable after the termination.
NCT01908751
Details
2020-11-30
Interventional
391 
Cholecalciferol Ergocalciferols Vitamin D Vitamins
Femoral Neck Fr… Fractures, Bone Hip Fractures
Continuing beyond the pilot phase of the trial was deemed unfeasible
-
NCT01494584
Details
2020-11-30
Interventional
25 
Ezogabine
Epilepsy
Terminated after placing the study on hold at the request of the FDA
-
NCT00588835
2007-003347-73
Details
2020-11-30
Interventional
4-
Aprepitant Dexamethasone Ondansetron
Tumor
-
-
NCT03206788
Details
2020-11-27
Interventional
27 
Losartan
Cystic Fibrosis Fibrosis
due to slow enrollment and approval of the Trikafta for CF patients
-
NCT00406419
Details
2020-11-27
Interventional
31015 
Methotrexate Ocrelizumab
Arthritis Arthritis, Rheu… Rheumatoid Arth…
Based on analysis of results and consideration of available treatments, the overall benefit to risk profile of ocrelizumab was not favorable in RA.
-
NCT02538614
Details
2020-11-25
Interventional
12 
BI 836826 Idelalisib
Leukemia Leukemia, Lymph… Leukemia, Lymph… Chronic Lymphoc…
-
-
NCT02435095
Details
2020-11-25
Interventional
4174 
Antipsychotic A…
Schizophrenia
slow patient recruitment, low patient-commpliance, high dropout rates,
-
NCT04290442
Details
2020-11-24
Interventional
40 
Ropivacaine
Acute Pain Anesthesia, Con… Arthroplasty, R…
initially cessation due to covid, then fellow doing the study graduated with no time to complete the study; will take up again if a current fellow takes on the project
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NCT02882711
Details
2020-11-24
Interventional
210 
Ketamine
Bipolar Disorde… Depression Depressive Diso… Depressive Diso… Depressive Diso… Major Depressiv… Treatment Resis…
Increasing off-label practice of IV ketamine administration for treatment-resistant depression.
Not reaching the target number of participants needed to achieve target power
NCT00269828
NCT00317824
Details
2020-11-24
Interventional
3-
Albumin-Bound P… Paclitaxel Paclitaxel poli…
Lung Neoplasms NSCLC
-
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NCT00079911
Details
2020-11-24
Interventional
47 
Valacyclovir
Herpes Genitali… Herpes Simplex
Terminated
-
NCT03488147
Details
2020-11-23
Interventional
20 
Esomeprazole
Deglutition Dis… Joint Diseases Osteoarthritis Degenerative Jo… Dysphagia GERD
Change in Investigational Drug Service policies resulting in the need to change the operational design of the overall protocol.
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NCT04365231
Details
2020-11-20
Interventional
30 
Azithromycin Hydroxychloroqu…
COVID-19 COVID19
no authorization obtained
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