Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03585062
Details
2021-01-08
Interventional
240 
Paclitaxel
Pancreatic Neop… Neoadjuvant Che… Pancreatic Canc…
The paclitaxel-albumin halt production.
-
NCT01569035
Details
2021-01-07
Interventional
4200 
Warfarin
Oligohydramnios
-
-
NCT03514277
Details
2021-01-06
Interventional
419 
Bupivacaine
Intervertebral … Intervertebral … Low Back Pain Radiculopathy Spondylolisthes… Spondylolysis Deformity of Sp… Lumbar Disc Deg… Lumbar Disc Her… Lumbosacral Rad… Stenosis
PI decision to close study early
Early termination leading to small numbers of subjects analyzed
NCT03342859
2017-000468-13
Details
2021-01-06
Interventional
110 
Ulipristal acet…
Leiomyoma Myofibroma
Due to findings in the preclinical carcinogenicity studies for vilaprisan (BAY1002670)
-
NCT03205046
Details
2021-01-06
Interventional
1/225 
Acalabrutinib
DLBCL Richter Syndrom…
Sponsor's decision not to pursue further development of the combination in DLBCL
Enrollment to this study was stopped early by the sponsor and an abbreviated CSR was generated.
NCT02619617
Details
2021-01-05
Interventional
228 
Pasireotide
Cluster Headach… Headache Cluster Headach…
Novartis decision based on Cohort 1 results
Terminated (Non-efficacy in first Phase 2a cohort.)
NCT02388165
2014-002644-40
Details
2021-01-05
Interventional
23450 
Vaccines
Staphylococcal …
Study terminated by sponsor
-
NCT02029274
2013-001799-39
Details
2021-01-05
Interventional
217 
Siponimod
Dermatomyositis Active Dermatom…
The study was terminated prematurely after an interim analysis for futility. The study did not provide any evidence for efficacy of BAF312 in dermatomyositis.
-
NCT01801917
Details
2021-01-05
Interventional
214 
Siponimod
Polymyositis
-
-
NCT00760929
2008-001736-12
Details
2021-01-05
Interventional
2171 
Antibodies, Mon… Erlotinib Hydro…
Carcinoma, Non-… Lung Neoplasms Non-Squamous No…
The study was terminated due to the termination of the clinical development program.
Development of the study drug R1570 was discontinued based on the available clinical data and the large number of molecules targeting the pathway. Not all efficacy parameters described in the protocol were assessed.
NCT03063359
Details
2020-12-31
Interventional
322 
Fentanyl Morphine
Acute Pain Pain, Acute
The new pain protocols imposed by the HAS make it difficult to include new patients in the study
-
NCT01721317
2012-003105-10
Details
2020-12-30
Interventional
46 
Ezogabine
Seizures
After reevaluation of the benefit: risk profile of ezogabine/retigabine, GSK does not believe the early adjunctive treatment study population is appropriate.
-
NCT03487198
Details
2020-12-29
Interventional
365 
Brexpiprazole
Depression Depressive Diso… Depressive Diso… Major Depressiv…
In consideration of the progress now and the expected enrollment in the next few years,the NDA will not be acquired before the patent went out.
-
NCT02559817
Details
2020-12-28
Interventional
2101 
Linaclotide
Constipation Irritable Bowel… Syndrome Irritable Bowel…
-
Due to slow participant enrollment, further screening was terminated. This decision was not due to any safety concern.
NCT01092975
Details
2020-12-28
Interventional
11 
Oxymetazoline Phenylephrine
Mucositis Stomatitis
formulation/dose changes; planned changes to safety monitoring/reporting
-
NCT02862535
Details
2020-12-24
Interventional
1
[4 Refs]
36 
Nivolumab Oxaliplatin
Adenocarcinoma Gastric Adenoca…
Study was terminated due to sponsor's decision to not pursue further development of andecaliximab in oncology
-
NCT01156415
Details
2020-12-24
Interventional
3837 
Agomelatine
Depression Depressive Diso… Depressive Diso… Major Depressiv…
-
-
NCT00738387
2008-002309-38
Details
2020-12-24
Interventional
3900 
Docetaxel Vadimezan
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
-
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NCT00662597
Details
2020-12-24
Interventional
31285 
Carboplatin Paclitaxel Vadimezan
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
-
-
NCT04681027
Details
2020-12-23
Interventional
315 
Oxymorphone
Chronic Pain Pain, Postopera… Postsurgical Pa…
Study Suspended 06Feb2020 per FDA Request
-