Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00141310
Details
2021-02-01
Interventional
2-
Sildenafil Citr…
Eclampsia Pre-Eclampsia Pre-eclampsia
Study prematurely discont'd 20-Apr-2006 after interim analysis suggested sample size could be reduced without losing power. No safety concerns led to decision.
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NCT00150306
Details
2021-01-29
Interventional
3-
Sertraline
Stress Disorder… Stress Disorder…
Please see Detailed Description below for termination reason.
-
NCT03055312
Details
2021-01-28
Interventional
336 
Bicalutamide
Breast Neoplasm… Triple Negative… Metastatic Trip…
-
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NCT01838044
Details
2021-01-28
Interventional
4180 
Celecoxib Pregabalin
Back Pain Low Back Pain Chronic Low Bac…
Recruitment terminated on 3Apr2015 due to slow recruitment rate and lack of operational feasibility. Study was not terminated for reasons of safety/efficacy.
The study was terminated as it had been determined that it was no longer operationally feasible to continue the trial. The study termination was not due to a safety issue or finding.
NCT01302938
Details
2021-01-28
Interventional
418 
Tolterodine Tar…
Urinary Bladder… Overactive Blad…
Stop date for randomization: 31/5/2012. Recruitment terminated due to lack of recruitment. No new safety issues were identified.
The study was terminated prematurely due to low participant enrollment and due to relatively small sample size; results should be interpreted with caution. Early termination of the study was not related to any safety concern.
NCT01145417
Details
2021-01-28
Interventional
3217 
Pregabalin
Neuralgia HIV-1 Infection Neuropathic Pai…
See termination reason in detailed description.
The parent double blind trial A0081244 (NCT01049217) was stopped at interim analysis due to lack of efficacy and therefore this open label extension study was also terminated.
NCT01049217
Details
2021-01-28
Interventional
3377 
Pregabalin
Neuralgia Peripheral Nerv… Neuropathy
See termination reason in detailed description.
Based on Data Monitoring Committee (DMC) interim efficacy analysis results indicating a low probability for success, the study was terminated on April 2, 2012; the termination was unrelated to any safety findings that could impact participant health.
NCT00905437
Details
2021-01-28
Interventional
372 
Pregabalin
Pain, Periopera…
The Study was terminated on May 24th 2012 due to a slow recruitment rate. The study was not terminated for reasons of safety or efficacy.
As the enrollment rate was very low, the study was prematurely terminated. The number of enrolled participants was too low for meaningful formal statistical conclusions.
NCT00635531
Details
2021-01-28
Interventional
416 
Alprazolam
Panic Disorder
Please see Detailed Description for termination reason.
-
NCT00635076
Details
2021-01-28
Interventional
43 
Alprazolam
Panic Disorder
Please see Detailed Description for the termination reason.
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NCT00634790
Details
2021-01-28
Interventional
449 
Alprazolam
Panic Disorder
Please see Detailed Description for termination reason.
-
NCT02282514
Details
2021-01-27
Interventional
1/2
[1 Refs]
23 
Cyclophosphamid… Methylprednisol… Methylprednisol… Rituximab Thymoglobulin
Stiff-Person Sy… Syndrome
Could not predict who would respond, relapse or go into remission
-
NCT00766142
Details
2021-01-26
Interventional
2
[1 Refs]
18 
Calcium Cetuximab Fluorouracil Leucovorin Levoleucovorin Oxaliplatin
Carcinoma Colorectal Neop… Peritoneal Neop… Colorectal Canc… Primary Periton…
In 2008, new data highlighted that Cetuximab had no efficacy in case of KRAS mutation. As such, eligibility criteria were revised and limited to KRAS wild-type. Inclusions were thus slown down considerably, and the trial was stopped.
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NCT03339401
Details
2021-01-25
Interventional
229 
Brincidofovir
Adenoviridae In… Adenovirus
terminated due to low enrollment rate
The study was terminated in May 2019 due to poor subject accrual rates. As a result, statistical analyses were not performed. Limited demographic, efficacy, and safety data are provided for the 29 subjects who were enrolled as descriptive summaries.
NCT00407797
Details
2021-01-25
Interventional
4136 
Pregabalin
Seizures Partial Seizure…
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NCT04456088
Details
2021-01-22
Interventional
20 
Nitric Oxide
COVID-19 Coronavirus Inf… Pneumonia, Vira… Respiration Dis… Respiratory Tra… Corona Virus In… Respiratory Dis… SARS-CoV 2
Terminated (halted prematurely)
-
NCT02602210
Details
2021-01-22
Interventional
3100 
Hydrocortisone Hydrocortisone …
Fibrosis Liver Cirrhosis Sepsis
low inclusion rate
-
NCT02446886
Details
2021-01-22
Interventional
415 
Adrenocorticotr… Hormones Melanocyte-Stim… beta-Endorphin
Multiple Sclero… Sclerosis
Slow enrollment
-
NCT01702558
2012-001547-46
Details
2021-01-22
Interventional
2182 
Ado-Trastuzumab… Capecitabine Maytansine Trastuzumab
Breast Neoplasm… Stomach Neoplas… Breast Cancer Gastric Cancer
The sponsor decided to terminate study after 70% of participants had experienced a progression-free survival event.
The sponsor decided to terminate the study after 70% of participants had experienced a PFS event. Participants were allowed to continue treatment by enrolling into study NCT00781612 or by moving to commercial drug, depending on their country.
NCT00738777
2008-000644-13
Details
2021-01-22
Interventional
2-
Anastrozole Fulvestrant Tamoxifen
Breast Neoplasm… Breast Cancer
in preparation for an amendment
-