Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00380874
Details
2021-02-11
Interventional
464 
Pregabalin
Peripheral Nerv… Chemotherapy-In…
See detailed description for termination reason
Due to lack of symptom emergence, enrollment was halted, and endpoint modified because primary assumptions upon which it was powered (emergence of symptomatology) were not met, and not all endpoints were able to be reliably analyzed.
NCT03368859
2017-003669-87
Details
2021-02-09
Interventional
270 
Bevacizumab Fluorouracil Irinotecan Leucovorin
Colorectal Neop… Cancer
Study may continue
-
NCT02697162
Details
2021-02-09
Interventional
2/30 
Anti-Infective … Octenidine
Catheter-Relate… Infections Urinary Bladder… Neurogenic Blad…
Withdrawal of research institution from participating
-
NCT04416399
Details
2021-02-08
Interventional
2146 
Budesonide
COVID-19 Coronavirus Inf… Infections Coronavirus Inf…
Independent statistical review advice
-
NCT00960804
Details
2021-02-08
Interventional
321 
Tanezumab
Osteoarthritis
See termination reason in detailed description.
Due to FDA-imposed clinical hold, enrollment stopped prematurely, thus inadequate power to fulfill primary objectives.Efficacy data beyond Week 32 not collected.Change in planned analysis added results of >=70%, 90% reduction in WOMAC pain subscale.
NCT04382625
Details
2021-02-05
Interventional
40 
Hydroxychloroqu…
COVID-19 Pneumonia SARS-CoV-2 Pneu…
Secondary to other study results, suspended for a scientific review
-
NCT02240160
2013-004459-19
Details
2021-02-05
Interventional
16 
Nabiximols
Healthy Volunte…
-
-
NCT03998592
Details
2021-02-04
Interventional
10 
Vaccines
Rheumatic Fever
Agreement between interested partied ended
-
NCT03680911
Details
2021-02-04
Interventional
37 
Acetylcysteine N-monoacetylcys…
Anosmia Craniocerebral … Wounds and Inju… Head Trauma
Poor participant compliance
-
NCT03319823
Details
2021-02-04
Interventional
40 
Sodium Chloride…
Hypertension Nocturia High Blood Pres…
Due to the Pandemic, we decided to end this study.
-
NCT00863772
Details
2021-02-04
Interventional
3220 
Tanezumab
Osteoarthritis
See termination reason in detailed description.
Due to US FDA imposed clinical hold (effective 23 June 2010), study was terminated early and planned sample size was not achieved. Due to change in planned analysis pre-specified outcome measure 'time to discontinuation due to lack of efficacy' was removed.
NCT02893332
Details
2021-02-03
Interventional
3-
Erlotinib Hydro… Gefitinib
Adenocarcinoma Adenocarcinoma … Stage IV EGFR M…
After interim analysis, IRB recommend termination.
-
NCT00750919
2007-005237-10
Details
2021-02-02
Interventional
3184 
Mirtazapine
Dyssomnias Mental Disorder… Parasomnias Sleep Disorders… Sleep Initiatio… Sleep Wake Diso… Sleep Disorders
This trial was stopped prematurely due to the Sponsor's decision not to continue the development of esmertazapine for this indication.
This study was terminated due to the Sponsor's decision not to continue development of esmertazapine for this indication.
NCT00638157
Details
2021-02-02
Interventional
424 
Daptomycin Gentamicins
Endocarditis Endocarditis, B… Infective Endoc…
commitment completed
As the study was terminated prematurely, conclusions that can be drawn from the efficacy results are limited.
NCT00584779
Details
2021-02-02
Interventional
48 
Gabapentin
Renal Insuffici… PK Properties O…
See detailed description for termination reason
-
NCT04729088
Details
2021-02-01
Interventional
10 
Isosorbide Isosorbide Dini… Isosorbide-5-mo…
Healthy Subject… Pharmacokinetic…
The sponsor will no longer develop the experimental drug.
-
NCT03721679
Details
2021-02-01
Interventional
1/2
[3 Refs]
7 
Atezolizumab Durvalumab Nivolumab Pembrolizumab Poly ICLC
Solid Cancer
Recruiting target patients is intermittent making it impracticable to enroll the required study sample. The administrative responsibilities have been met with extraordinary challenges. Current funding does not match the incurring costs.
-
NCT03515707
Details
2021-02-01
Interventional
20 
Busulfan Etoposide Etoposide phosp… Podophyllotoxin
Leukemia Leukemia, Myelo… Leukemia, Myelo… Neoplasm, Resid… Acute Myeloid L… Minimal Residua…
PI recommended closure
-
NCT03484650
Details
2021-02-01
Interventional
30 
Lidocaine
Hernia, Ventral Pain, Postopera… Post Operative …
Lack of available resources to complete study
-
NCT02730091
Details
2021-02-01
Interventional
398 
Anastrozole Letrozole Vinorelbine
Breast Neoplasm… Breast Cancer
-
-