Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03207867
2017-000241-49
Details
2024-03-01
Interventional
2315 
Spartalizumab
Carcinoma, Rena… Lymphoma Lymphoma, Non-H… Triple Negative… DLBCL, Diffused… Head and Neck C… MSS, Microsatel… Melanoma NSCLC, Non Smal… Pancreatic Canc… RCC, Renal Cell… TNBC, Triple Ne… Urothelial Canc… mCRPC, Metastat…
Sponsor decision
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NCT05481112
Details
2024-02-29
Interventional
40 
Buprenorphine
Opioid-Related … Opioid Use Diso…
This study was not initiated due to policy changes in Massachusetts (the proposed study sites).
-
NCT04629196
Details
2024-02-29
Interventional
425 
Ustekinumab
Crohn Disease
Other effective drugs have been introduced to market since the beginning of the study.
-
NCT03711279
Details
2024-02-29
Interventional
299 
Apatinib
Sarcoma
Sponsor R & D Strategy Adjustment
-
NCT03585465
Details
2024-02-29
Interventional
1/2-
Capecitabine Cyclophosphamid… Nivolumab Vinblastine
Neoplasms Childhood Solid…
Interim analysis
-
NCT05703555
2022-003451-34
Details
2024-02-28
Interventional
20 
Maytansine
Stomach Neoplas… Metastatic Brea… Metastatic Gast… Metastatic Lung…
Due to the decision to discontinue the global clinical development program of tusamitamab ravtansine
-
NCT05683574
Details
2024-02-28
Interventional
30 
Amitriptyline Cyclobenzaprine Etoricoxib
Third Molar Ext…
Change in study strategy.
-
NCT05643573
2022-000758-28
2023-503794-38
Details
2024-02-28
Interventional
314830 
Apixaban
Atrial Fibrilla… Embolism Stroke Prevention of S…
Independent Data Monitoring Committee (IDMC) recommendation to stop the study
-
NCT05405686
Details
2024-02-28
Interventional
40 
Follicle Stimul…
Poor Response t…
withdrawn due to practical reasons
-
NCT05331053
Details
2024-02-28
Interventional
46 
Atorvastatin
Endometriosis
COVID halting human subjects research and preliminary data from this proposal were used to submit an NIH grant. The NIH grant was funded and 3 other protocols were launched.
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NCT04936971
Details
2024-02-28
Interventional
40 
Everolimus Mycophenolic Ac…
Cytomegalovirus… Kidney Transpla…
Impossibility to perform tests (elispot) of the study due to change of location of laboratory
-
NCT04921358
2022-001779-15
Details
2024-02-28
Interventional
3377 
Docetaxel Tislelizumab
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Due to safety risks and unfavorable risk-benefit assessment results, the sponsor has decided to voluntarily terminate the study.
-
NCT04058132
Details
2024-02-28
Interventional
2
[9 Refs]
1 
Sildenafil Citr…
Brain Injuries Brain Injuries,… Wounds and Inju… Traumatic Brain…
funding ran out after unanticipated length of time ( for IRB approval, CRADA, and start letter
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NCT03792503
Details
2024-02-28
Interventional
40 
Apatinib Pemetrexed
Carcinoma, Non-… Lung Neoplasms Advanced Non-sq…
abandon
-
NCT03190239
Details
2024-02-28
Interventional
20 
Apatinib Pemetrexed
Carcinoma, Non-… Lung Neoplasms Advanced Non-sq…
abandon
-
NCT03179163
Details
2024-02-28
Interventional
1/210 
Captopril Enalapril Hydrochlorothia…
Essential Hyper… Hypertension Hypertension,Es…
COVID shut down human subjects research and then the grant funding expired
-
NCT00609154
Details
2024-02-28
Interventional
1/220 
Glucagon Glucagon-Like P… Incretins
Diabetes Mellit… Type 2 Diabetes
Per source documents the study was terminated well in advance of targeted enrollment. A method for the analysis of insulin and proinsulin samples was never fully developed and validated. Study terminated upon expiration of IRB approval
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NCT06083675
Details
2024-02-26
Interventional
30 
Empagliflozin Metformin Semaglutide
Diabetes Mellit… Diabetes Mellit…
Due to internal reprioritization, trial was cancelled.
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NCT05700630
Details
2024-02-26
Interventional
10 
Vorinostat
Communicable Di… Infections Viremia ART Cd4+ Lymphocyte… HIV-1-infection Interleukin Lymphoid Tissue…
Abandoned
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NCT05474690
Details
2024-02-26
Interventional
30 
Carboplatin Cyclophosphamid… Docetaxel Epirubicin Pertuzumab Trastuzumab
Breast Neoplasm… Breast Cancer HER2-positive B…
The new treatment plan for HER2 positive breast cancer has entered the diagnosis and treatment guide. The treatment plan ECHP-THP in this study is not the optimal treatment plan, therefore this study was terminated.
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