Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03140722
Details
2021-02-21
Interventional
22 
Epoetin Alfa
Anemia Kidney Diseases Renal Insuffici… Dialysis-Depend…
Revised study design.
The Study was closed by the Sponsor as it was determined that it was more appropriate to initiate a new study that would explore the broader population utilizing a modified dosing approach (rather than amending the current protocol design).
NCT02244112
Details
2021-02-21
Interventional
143 
Midazolam
Neoplasms Advanced Non-Ce…
Why study stopped revised to "A program evaluation identified that the safety profile and pharmacokinetic (PK) characteristics of the formulation used in all oprozomib studies required further optimization and thus enrollment in OPZ009 was halted
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NCT00645229
Details
2021-02-21
Interventional
31 
Ziprasidone
Psychotic Disor… Schizophrenia Schizoaffective…
Please see Detailed Description for termination reason.
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NCT00585312
NCT00393016
NCT00534040
Details
2021-02-21
Interventional
3106 
Celecoxib
Adenomatous Pol… Colorectal Neop… Nasopharyngeal …
See termination reason in detailed description.
The study was early terminated and, due to the low number of participants, no efficacy analysis was performed. Only descriptive statistics was performed.
NCT00159757
Details
2021-02-21
Interventional
4-
Ziprasidone
Schizophrenia
See Detailed Description for Termination Reason
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NCT02620904
Details
2021-02-18
Interventional
49 
Mifepristone
Fetal Death Stillbirth Intrauterine Fe…
unable to recruit. Projected completion was 2018 however, enrollment and recruitment were difficult. The study was terminated due to inability to enroll.
Due to difficulty with recruitment the study was unable to be completed in the projected time frame. Despite efforts to enhance recruitment and extending the study duration very few persons were enrolled. Due to the limited enrollment no conclusions can be ascertained about the impact of mifepristone on the induction of labor in this setting.
NCT00640549
Details
2021-02-18
Interventional
441 
Atorvastatin
Diabetes Mellit… Diabetes Mellit… Hyperlipidemias Hyperlipoprotei… Hyperlipidemia Non-Insulin Dep…
See termination reason in detailed description.
-
NCT00040144
Details
2021-02-18
Interventional
2-
Dexelvucitabine
Hepatitis Hepatitis A Hepatitis B Hepatitis B, Ch… Hepatitis, Chro… Chronic Hepatit…
Safety concerns
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NCT04077398
Details
2021-02-16
Interventional
40 
Ropivacaine
Pain, Postopera… Analgesia Block Postoperative P…
covid interrupted initial start, then trainees involved finished program and no one took it on
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NCT03758729
Details
2021-02-16
Interventional
20 
Nivolumab
Melanoma
Internal Issues
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NCT03574857
Details
2021-02-16
Interventional
45 
Chlorothiazide Metolazone
Cardiovascular … Heart Failure Heart Failure A… Heart Failure W…
Low enrollment
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NCT03197025
Details
2021-02-16
Interventional
11 
Aldesleukin Interleukin-2
Carcinoma in Si… Carcinoma, Squa… Squamous Intrae… HPV-16 High Grade Squa… Human Papilloma…
The study was closed due to investigator discretion based on the lack of perceived clinical activity observed in the study.
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NCT02973711
Details
2021-02-16
Interventional
1/20 
Nilotinib
Leukemia, Myelo… Leukemia, Myelo… Leukemia, Chron…
lack of funding
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NCT04391868
Details
2021-02-15
Interventional
10 
Citric Acid Sildenafil Citr… Sodium Citrate
Healthy
The project has been transferred to Viatris
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NCT03678480
Details
2021-02-15
Interventional
20 
Ursodeoxycholic…
Bile Duct Disea… Biliary Tract D… Cholangitis Cholangitis, Sc… Digestive Syste… Gastrointestina… Adolescent Primary Scleros…
Corporate decision
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NCT03001349
Details
2021-02-15
Interventional
14 
Edotreotide Octreotide
Endocrine Gland… Meningioma Multiple Endocr… Multiple Endocr… Neoplasms Neuroendocrine … Von Hippel-Lind… Metastatic Well… Neuroendocrine … Somatostatin Po… Von Hippel-Lind…
Per PI Request
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NCT02384954
Details
2021-02-15
Interventional
1/243 
Rituximab
Lymphoma Lymphoma, B-Cel… Lymphoma, Non-H… Relapsed/Refrac…
Change in drug product development strategy.
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NCT00790478
Details
2021-02-12
Interventional
23 
Melatonin
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
-
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NCT04274907
Details
2021-02-11
Interventional
12 
Pembrolizumab Venetoclax
Carcinoma, Non-… Lung Neoplasms Cancer Non Small Cell …
Company Decision
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NCT03841773
Details
2021-02-11
Interventional
3192 
Cyclobenzaprine
Stress Disorder… PTSD
Interim Analysis results
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