Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00265382
Details
2021-03-03
Interventional
3221 
Ziprasidone
Schizophrenia
Please see Detailed Description for termination reason.
The AE tables were amended to incorporate previously unreported AEs that were found during an independent audit and verified by the investigators.
NCT00163241
Details
2021-03-03
Interventional
3-
Celecoxib
Osteoarthritis Osteoarthritis,…
Please see detailed description for termination reason.
-
NCT03811951
Details
2021-03-02
Interventional
24 
Insulin
Smoking Cessati…
Different study initiation
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NCT02255461
Details
2021-03-02
Interventional
135 
Palbociclib
Astrocytoma Central Nervous… Choroid Plexus … Glioblastoma Gliosarcoma Medulloblastoma Meningioma Neoplasms Neoplasms, Neur… Nervous System … Neuroectodermal… Neuroectodermal… Oligodendroglio… Pinealoma Recurrence Childhood Choro… Childhood Epend… Childhood Grade… Childhood High-… Childhood High-… Childhood Medul… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child… Recurrent Child…
Data for the primary objectives is complete and the MTD identified in Stratum II.
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NCT03474510
Details
2021-03-01
Interventional
40 
Bupivacaine Ropivacaine
Pain, Postopera… Shoulder Osteoa…
Investigator Decision
-
NCT02684617
Details
2021-03-01
Interventional
175 
Pembrolizumab
Hematologic Neo… rrCLL rrDLBCL rrMM
Business Reasons
-
NCT03832673
Details
2021-02-26
Interventional
20 
Pembrolizumab
Urinary Bladder… Muscle-invasive…
Regolatory National Agency (AIFA) not approved
-
NCT01714817
2012-000714-11
Details
2021-02-26
Interventional
3695 
Abatacept Mycophenolic Ac… Prednisone
Lupus Nephritis Nephritis
Inability to meet protocol objectives.
Study terminated early after review of Year 1 data. Only Year 2/LTE data captured within blind was analyzed. Outcomes related to renal responses were not calculated due to lack of data caused by the early termination.
NCT01334047
Details
2021-02-26
Interventional
1/25 
Vaccines
Carcinoma, Ovar… Ovarian Neoplas… Recurrence Recurrent Epith…
The study needed to be terminated due to new knowledge about cancer vaccines. A new protocol with an expected more efficient vaccine is currently being written.
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NCT00961844
2008-006253-41
Details
2021-02-26
Interventional
1/215 
Temozolomide
Melanoma Metastatic Mali…
Logistical problems
-
NCT00864097
2009-009318-41
Details
2021-02-26
Interventional
3607 
Diclofenac Tanezumab
Osteoarthritis Osteoarthritis,…
See termination reason in detailed description.
Due to United States Food and Drug Administration (FDA) imposed clinical hold, further study drug dosing was stopped prematurely and study was terminated.
NCT02687269
Details
2021-02-25
Interventional
40 
Ranolazine
Myocardial Stun…
Inability to produce placebo tablets similar to the drug tested
-
NCT02687100
Details
2021-02-25
Interventional
40 
Beclomethasone
Pharyngitis Anesthesia, End…
Due to instillation site of the cortisone and the development of the related SARS-Cov2 infection, it was preferred to terminate the trial and develop it again without beclomethasone
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NCT03814148
Details
2021-02-24
Interventional
30 
Indapamide
Hypertension Arterial Hypert…
The design of this protocol was rewritten due to regulatory recommendations.
-
NCT01087203
Details
2021-02-24
Interventional
273 
Tanezumab
Diabetic Neurop… Peripheral Nerv… Diabetic Periph…
See termination reason in detailed description.
This study was terminated following a United States (US) Food and Drug Administration (FDA) partial clinical hold.
NCT04084158
Details
2021-02-23
Interventional
2-
Albumin-Bound P… Paclitaxel
Carcinoma Carcinoma, Squa… Esophageal Squa…
combination arm delevelped significant poor prognosis
-
NCT03224585
Details
2021-02-23
Interventional
25 
Interleukin 1 R…
Pericarditis Acute Pericardi…
Study was terminated because dramatic benefits seen during the first 24 hours of drug administration combined with COVID restrictions on research activities suggested it was both unethical and unnecessary to complete the planned enrollment
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NCT00324740
Details
2021-02-23
Interventional
1/214 
Isotretinoin Vorinostat
Carcinoma, Rena… Recurrent Renal… Stage III Renal… Stage IV Renal …
-
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NCT03696212
Details
2021-02-21
Interventional
1/218 
Pembrolizumab
Adenocarcinoma Adenocarcinoma … Carcinoma, Non-… Lung Neoplasms Non-small Cell …
Based on the totality of the generated combined safety and efficacy data in the interim period, the company decided to terminate the combination study in NSCLC patients. There are no subjects on study drug at this time or in the EOT Follow-up period.
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NCT03490942
Details
2021-02-21
Interventional
249 
Glucagon Glucagon-Like P…
Diabetes Mellit… Diabetes Mellit… Hypoglycemia Hypoglycemia Un…
Primary endpoint was not met
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