Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT04056650
Details
2021-03-12
Interventional
457 
Caffeine
Cognitive Perfo…
Low enrollment
-
NCT01846182
Details
2021-03-12
Interventional
2112 
Duloxetine Hydr… Pregabalin
Gulf War Illnes…
Terminated by Funder
The study was closed by the sponsor. Recruiting was very difficult and there were multiple irregularities in enrollment, data collection, and study management. The data are unreliable for interpretation.
NCT00865280
Details
2021-03-12
Interventional
3143 
Linezolid Moxifloxacin
Communicable Di… Infections Skin Diseases Skin Diseases, … Skin Diseases, …
Terminated
Changes in Food and Drug Administration (FDA) criteria for the identification and enrollment of participants with complicated skin and skin structure infections as well as the primary endpoint led to administrative termination of the study.
NCT04372082
2020-002188-72
Details
2021-03-11
Interventional
30 
Diltiazem Hydroxychloroqu… Niclosamide
Sars-CoV2
evidence showed chloroquine is not effective against COVID-19
-
NCT00775268
Details
2021-03-11
Interventional
1/231 
Fluorodeoxygluc…
Lymphoma
-
-
NCT04239014
Details
2021-03-10
Interventional
20 
Olaparib
Carcinoma, Ovar… Ovarian Neoplas… Ovarian Cancer
Sponsor made the decision to terminate the DUETTE study based on the interim analysis of the VIOLETTE study (NCT03330847) investigating the combination of ceralasertib and Olaparib, where study closure was recommended due to insufficient efficacy.
-
NCT04222842
Details
2021-03-10
Interventional
1-
Vorolanib
Choroidal Neova… Myopia Neovascularizat… Myopic Choroida…
Day is not required for Anticipated dates.
-
NCT04057261
Details
2021-03-10
Interventional
30 
Liraglutide
Cardiovascular … Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
A study start is currently not foreseeable for organizational reasons. Due to the delays, research has also been focused on new compounds, which has reduced the interest in the potential results of the above-mentioned clinical trial.
-
NCT01127893
Details
2021-03-10
Interventional
31 
Tanezumab
Osteoarthritis
See termination reason in detailed description.
Due to the US FDA imposed clinical hold, enrollment and further dosing with study medication was stopped prematurely, only 1 participant was enrolled and the study was terminated early. Designation of outcomes as primary, secondary based on study team input as study did not specify them as primary or secondary.
NCT03661983
2018-002270-48
Details
2021-03-09
Interventional
436 
Aripiprazole
Tourette Syndro… Tourette's Diso…
Lack of feasibility for completion of the trial within a reasonable time frame.
This trial was terminated early due to the withdrawal of post-marketing commitment (PMC) to FDA. The planned interim analysis was not conducted either.
NCT01206296
Details
2021-03-09
Interventional
29 
Gemcitabine
Adenocarcinoma Pancreatic Aden…
Study suspended
-
NCT03258476
Details
2021-03-08
Interventional
40 
Guanfacine
Stress Disorder… Stress Disorder
Contract terminated
-
NCT04374279
Details
2021-03-05
Interventional
20 
Bicalutamide
COVID-19 SARS-CoV 2
Limited resources.
-
NCT03600467
Details
2021-03-05
Interventional
24 
Seviteronel
Androgen Recept… Solid Tumor
Sponsor
-
NCT03198221
Details
2021-03-04
Interventional
414 
Citric Acid Magnesium Oxide Picosulfate sod… Polyethylene gl…
Bowel Preparati…
Low enrollment due to difficult eligibility criteria and participant prep logistics
-
NCT04543916
Details
2021-03-03
Interventional
1/20 
Irinotecan Venetoclax
Lung Neoplasms Small Cell Lung… Refractory Smal… Relapsed Small …
AbbVie decided to stop trial involving Venetoclax for safety measures needed
-
NCT02796144
Details
2021-03-03
Interventional
471 
Metformin
Overweight Psychotic Disor… Schizophrenia Weight Loss Schizoaffective…
The FDA advised of a possible health risk associated with lorcaserin and the drug is being withdrawn.
-
NCT02340156
Details
2021-03-03
Interventional
21 
Temozolomide
Glioblastoma Recurrence RECURRENT GLIOB…
-
The number of participant was too small for statistical analysis. The study was terminated.
NCT00748566
Details
2021-03-03
Interventional
4172 
Ziprasidone
Mental Disorder… Metabolic Syndr… Psychotic Disor… Schizophrenia Schizophrenia S… Schizophrenia a…
See Detailed Description
The study was prematurely terminated by sponsor due to changes in organizational strategy and resources, not due to safety concerns.
NCT00359151
Details
2021-03-03
Interventional
422 
Celecoxib
Osteoarthritis Pain
This study was terminated early due to slow enrollment.
-