Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03398837
Details
2021-03-29
Interventional
3365 
Dronabinol Lenabasum
Scleroderma, Di… Scleroderma, Sy… Sclerosis Diffuse Cutaneo…
Sponsor terminated open-label extension
-
NCT03890341
Details
2021-03-26
Interventional
10 
Betadex Drospirenone Drospirenone an… Ethinyl Estradi… Midazolam
Healthy
Stopped due to a strategic decision.
-
NCT02353754
Details
2021-03-26
Interventional
412 
Bupivacaine Morphine
Pain
Slow enrollment. None of the subjects received EXPAREL.
-
NCT04683237
Details
2021-03-25
Interventional
2/30 
Liraglutide Megestrol Megestrol Aceta…
Endometrial Hyp… Hyperplasia Infertility Atypical Endome… Fertility Issue… Obese
Based on our latest research results, we will revise the protocol and design a better study. Since no participants are enrolled till now, we withdraw this study.
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NCT00257192
Details
2021-03-25
Interventional
3284 
Ziprasidone
Schizophrenia
Please see Detailed Description for termination reason.
The AE tables were amended to incorporate previously unreported AEs that were found during an independent audit and verified by the investigators.
NCT03042312
Details
2021-03-24
Interventional
271 
Pluvicto
Prostatic Neopl… Metastatic Cast…
Recruitment was stopped before the target sample size was achieved.
The study began on 05-Jul-17 as an Investigator Initiated Trial and sponsorship was transferred to Endocyte on 01-Jun-18. Recruitment was stopped before the target sample size was achieved based on strategic considerations.
NCT01146561
2010-019012-21
Details
2021-03-23
Interventional
22 
Tanezumab
Pancreatitis Pancreatitis, C… Chronic Pancrea…
See termination reason in detailed description.
Due to FDA clinical hold, the study was prematurely terminated with only 2 participants were enrolled and randomized to placebo treatment and hence, efficacy and pharmacokinetic analysis was not performed.
NCT02750514
Details
2021-03-22
Interventional
2295 
Dasatinib Ipilimumab Linrodostat Nivolumab Relatlimab
Carcinoma, Non-… Advanced Cancer
The standard of care for the patient population changed and we were unable to accrue any longer.
This study was terminated early by sponsor for reasons unrelated to safety.
NCT00055575
Details
2021-03-22
Interventional
2197 
Butylscopolammo… Scopolamine
Bipolar Disorde… Depression Depressive Diso… Mood Disorders Bipolar Depress… Healthy Unipolar Depres…
-
-
NCT04495010
2020-000070-16
Details
2021-03-19
Interventional
20 
Ipilimumab Nivolumab
Melanoma
Business objectives have changed
-
NCT00130312
NCT00342238
Details
2021-03-19
Interventional
4968 
Glucuronyl gluc…
Diabetic Nephro… Kidney Diseases Diabetic Nephro…
No difference in protein excretion at 6&12 months. No safety issues.
-
NCT03992326
Details
2021-03-18
Interventional
16 
Cyclophosphamid… Fludarabine Interleukin-2
Neoplasms Solid Tumor, Ad…
Internal competitive study that is open
-
NCT03003195
Details
2021-03-18
Interventional
20 
Monatide (IMS 3…
Neoplasm Metast… Neoplasms Neoplasms by Si… Neoplasms, Seco… Metastatic Canc…
Lack of Funding
-
NCT02272699
Details
2021-03-18
Interventional
2/30 
Nimotuzumab Paclitaxel
Carcinoma Carcinoma, Squa… Esophageal Squa…
Because there are questions about adjuvant radiotherapy in this study, the clinical trial is under re-design.
-
NCT01093638
Details
2021-03-18
Interventional
233 
Insulin
Premature Birth Premature Birth…
-
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NCT02605694
2015-004729-15
Details
2021-03-17
Interventional
20 
Prednisone Rituximab
Lymphoma Lymphoma, Folli…
Sponsor is focusing on studies which can enable registration of duvelisib
-
NCT02576275
Details
2021-03-17
Interventional
30 
Bendamustine Hy… Rituximab
Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, Folli… Lymphoma, Non-H… Follicular Lymp… Indolent Non-Ho… Marginal Zone L… Small Lymphocyt…
The scope of the program has been reduced to focus resources on studies which can potentially enable the registration of duvelisib.
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NCT00610935
Details
2021-03-17
Interventional
382 
Peramivir
Influenza, Huma… Influenza
This study was terminated for administrative reasons.
The study was terminated at the discretion of the Sponsor after 82 of the planned 600 subjects were enrolled. The reason for study termination was to allow the Sponsor to focus development efforts on a more concentrated formulation which would also allow evaluation of higher doses of peramivir administered intramuscularly.
NCT03723824
Details
2021-03-16
Interventional
4
[3 Refs]
14 
Elbasvir-grazop… Grazoprevir
Communicable Di… Hepatitis Hepatitis A Hepatitis C Hepatitis C, Ch… Hepatitis, Chro… Infections Chronic Hepatit… Kidney Transpla… Liver Transplan…
COV-19 pandemic
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NCT03549689
Details
2021-03-15
Interventional
20 
Dolutegravir Lamivudine Tenofovir
Bone Diseases, … HIV-1-infection HIV/AIDS Osteopenia
Withdrawn by drug manufacturer
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