Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02817113
Details
2021-04-30
Interventional
14 
Cetuximab Fluorouracil
Head and Neck N…
Strategy change
-
NCT02038699
Details
2021-04-30
Interventional
1/20 
TIC10 compound
Glioblastoma Triple Negative… Advanced Colore… Advanced Gliobl… Advanced Non-sm… Advanced Triple…
Protocol not activated.
-
NCT00784693
Details
2021-04-30
Interventional
248 
Tanezumab
Endometriosis
Further recruitment into the study was ceased on 10th December 2009, not attributed to safety. All patients recruited in the study completed all study visits.
Nerve growth factor (NGF) results were reported only for plasma since a reliable assay was not available for analyzing NGF in urine. Study was prematurely terminated and recruitment was stopped due to futility shown in pre-planned interim analysis.
NCT04374942
Details
2021-04-29
Interventional
313 
Hydroxychloroqu…
Coronavirus Inf… Coronavirus Pre-Exposure Pr… SARS-CoV 2
Due to unproven issues associated with hydroxychloroquine use and safety, further complicated by media and political misinformation which in effect rendered all global studies on HCQ to stop enrolling participants.
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NCT03935815
Details
2021-04-28
Interventional
1
[5 Refs]
26 
Ropivacaine
Laparoscopic My… Quadratus Lumbo…
Closed prior to completion secondary to surgeon leaving UCLA
-
NCT03846258
Details
2021-04-28
Interventional
40 
Pharmaceutical …
Acidosis Acute Kidney In… Renal Insuffici… Acute Kidney Fa… Metabolic Acido…
Due to the fact that we were unable to find subjects who met all inclusion and exclusion criteria it was determined to withdraw this study.
-
NCT03348735
Details
2021-04-28
Interventional
433 
Capsaicin Lidocaine Pregabalin
Neuralgia Neuropathic Pai…
Low inclusion rate
-
NCT02651116
Details
2021-04-28
Interventional
4131 
Dextromethorpha… Levomethorphan
Cough
The study was prematurely discontinued due to slow enrollment during the 2019/2020 cold season. No safety or efficacy concerns led to the decision to terminate
-
NCT01185366
Details
2021-04-28
Interventional
273 
Everolimus Sunitinib
Carcinoma Carcinoma, Rena… Kidney Neoplasm… Kidney Cancer
-
-
NCT04365582
Details
2021-04-27
Interventional
30 
Azithromycin Hydroxychloroqu… Lopinavir Ritonavir
COVID
The PI decided.
-
NCT04126044
Details
2021-04-27
Interventional
10 
Bevacizumab
Pharmacokinetic…
The study was withdrawn prior to enrollment after a comprehensive review of the biosimilars market and the company's global manufacturing network.
-
NCT03426137
Details
2021-04-27
Interventional
23 
Ketorolac Oxycodone
Acute Pain Opioid Use Spine Fusion Trauma
The focus of the project has shifted to publishing a protocol for future trials because we were unable to recruit. Three participants signed the consent forms but withdrew before the randomization.
Early termination due to logistical and funding issues, which lead to no analyzable data. A protocol paper has been published should other investigators wish to use the study design (DOI: 10.1136/bmjopen-2019-030623).
NCT03051672
Details
2021-04-27
Interventional
2
[1 Refs]
8 
Pembrolizumab
Breast Neoplasm… Metastatic Brea…
Based on two-stage design, the study ended at stage 1 with no evidence of promise based on pre-specified decision rule.
-
NCT01999335
Details
2021-04-27
Interventional
133 
Dexamethasone Pomalidomide
Multiple Myelom… Neoplasms, Plas…
A program evaluation identified that the safety profile and pharmacokinetic (PK) characteristics of the formulation used in all oprozomib studies required further optimization and thus enrollment in OPZ007 was halted during dose-expansion.
-
NCT04455958
Details
2021-04-26
Interventional
20 
Lopinavir Ritonavir
COVID-19 Laboratory Infe… Neoplasms Hematopoietic a… Malignant Solid… Symptomatic COV…
limited resources
-
NCT04303377
2018-001065-17
Details
2021-04-26
Interventional
20 
Evolocumab
Infarction Myocardial Infa… ST Elevation My… ST-elevation My…
The sponsor required early termination of the economic agreement due to a supposed extension of the enrollment period for bureaucracy reasons and for the concomitant Covid -19 Pandemic
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NCT01972854
Details
2021-04-26
Interventional
392 
Pharmaceutical … Riboflavin
Keratoconus
-
-
NCT01893359
Details
2021-04-26
Interventional
1/22 
Dextrans Ophthalmic Solu… Riboflavin
Astigmatism Hyperopia Hyperopic Astig…
-
-
NCT01643252
Details
2021-04-26
Interventional
30 
Ophthalmic Solu… Pharmaceutical … Riboflavin
Corneal Disease… Dilatation, Pat… Corneal Ectasia
This study was withdrawn for business reasons.
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NCT04663269
Details
2021-04-23
Interventional
45 
Dexamethasone
Kidney Calculi Kidney Stone Surgery
Drop out from surgeons from 3 to 1. It will take too long to feasibly accrue with only one provider.
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