Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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Trial ID Phase Status Type
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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02475369
Details
2021-05-12
Interventional
421 
Pancreatin Pancrelipase
Celiac Disease
The trial was terminated prematurely by the sponsor for administrative reasons.
Early termination by the sponsor leading to a small number of subjects analyzed.
NCT02097732
Details
2021-05-12
Interventional
24 
Ipilimumab
Brain Neoplasms Melanoma Neoplasm Metast… Brain Metastase… Metastatic Mela…
Study halted prematurely due to a change in the standard of care treatment
Study halted prematurely due to a change in the standard of care treatment.
NCT01562626
Details
2021-05-12
Interventional
1/2-
Flucytosine
Cancer Neoplasms Tumors
-
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NCT03292653
2017-002774-39
Details
2021-05-11
Interventional
232 
(2S,3R,4R,5S,6R…
Heart Failure Cardiac Failure…
1st two cohorts provided the required data, therefore 3rd cohort was not deemed necessary
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NCT03673735
2018-002730-21
Details
2021-05-10
Interventional
30 
Durvalumab
Carcinoma Squamous Cell H…
Company withdrew interest
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NCT03658213
Details
2021-05-10
Interventional
30 
Goserelin
Breast Neoplasm… Breast Cancer
CTP of LARES has been out of the expire date, we are trying RWS pathway for the indication expend
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NCT00809783
Details
2021-05-10
Interventional
32147 
Tanezumab
Osteoarthritis
See termination reason in detailed description.
Due to FDA imposed clinical hold, enrollment was stopped prematurely and, therefore, not all study procedures and visits occurred as planned.
NCT03844932
Details
2021-05-07
Interventional
2235 
Cyclosporine Cyclosporins
Colitis Colitis, Ulcera… Ulcer
The Sublimity Board of Directors carefully evaluated the IA data: the 9.6% treatment remission difference for 75mg BID vs placebo (due to an increase in placebo response rate) was determined not sufficient to continue to fund the study
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NCT04469062
2019-001653-99
Details
2021-05-06
Interventional
30 
Mirikizumab Vedolizumab
Colitis Colitis, Ulcera… Ulcer Ulcerative Coli…
The trial was terminated secondary to a business decision, the original scientific question rendered moot by the external scientific community.
-
NCT04173611
Details
2021-05-06
Interventional
120 
Bupivacaine
Healthy
Terminated for strategic and administrative reasons
-
NCT02959437
Details
2021-05-06
Interventional
1/270 
Azacitidine INCB057643 Pembrolizumab
Neoplasm Metast… Neoplasms Advanced Malign… Metastatic Canc… Solid Tumors
Study terminated by Sponsor
-
NCT00003056
Details
2021-05-06
Interventional
3105 
Cyclosporine Cyclosporins Methotrexate
Graft vs Host D… Leukemia Lymphoma Graft Versus Ho…
Interim analysis indicated study should be terminated
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NCT01541670
Details
2021-05-05
Interventional
14 
Antibodies
Lupus Erythemat… Lupus Nephritis Nephritis Systemic Lupus …
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-
NCT01089725
Details
2021-05-05
Interventional
3385 
Tanezumab
Osteoarthritis Arthritis Pain
See termination reason in detailed description.
Due to United States Food and Drug Administration (FDA) imposed clinical hold, enrollment was stopped prematurely and, therefore, was insufficient to yield adequate power to fulfill the primary objectives.
NCT01126216
2005-003484-23
Details
2021-05-04
Interventional
3221 
Cisplatin Paclitaxel
Head and Neck N… Head and Neck C…
After an Interims analysis the Data Safety Monitoring board recommended this because no significant difference between the two arms was seen and was not expected with an reasonable recruitment of patients. No interruptions of the trial were made.
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NCT04342221
2020-001224-33
Details
2021-05-03
Interventional
330 
Hydroxychloroqu…
COVID-19 COVID-19, Hydro…
Reduced acceptance of IMP
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NCT03749590
2009-013294-18
Details
2021-05-03
Interventional
3327 
Magnesium Sulfa…
Pancreatitis Post-ERCP Pancr…
The design of the MagPEP trial is no longer in compliance with the current state of science.
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NCT02899702
Details
2021-05-03
Interventional
40 
Immunoglobulins…
Communicable Di… Infections Shock Shock, Septic Staphylococcal … Streptococcal I… Staphylococcal … Streptococcal I…
no EC approval obtained
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NCT02860494
2018-002531-18
Details
2021-05-03
Interventional
2/30 
Everolimus
Angiofibroma Sclerosis Tuberous Sclero… Facial Angiofib…
Pharmaceutical and financial difficulties
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NCT03376854
Details
2021-04-30
Interventional
20 
Neuromuscular B…
Acute Lung Inju… COVID-19 Hypothermia Respiratory Dis… Respiratory Dis… Respiratory Dis… Sars-CoV2
Competition from other studies and initiation of a larger multi center trial
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