Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT02995642
Details
2021-05-21
Interventional
20 
Arginyl-glycyl-…
Aneurysm Aortic Aneurysm Aortic Aneurysm… Atherosclerosis Carotid Artery … Inflammation Carotid Atheros…
Resources not secured
-
NCT02056288
Details
2021-05-21
Interventional
478 
Fentanyl Ropivacaine
Fractures, Bone Supracondylar F…
Enrollment was suspended due to the duration of the study and poor follow-up response by participants.
-
NCT03540160
2017-004211-40
Details
2021-05-20
Interventional
3558 
Serlopitant
Dermatitis Prurigo Pruritus Psoriasis Atopic Dermatit… Prurigo Nodular…
No longer pursuing development of serlopitant
Due to a corporate decision to no longer pursue an indication of treatment for pruritus, and further to terminate the development program for serlopitant, the study was terminated prematurely.
NCT02975271
Details
2021-05-20
Interventional
21 
Serlopitant
Burns Pruritus
Business Reasons
-
NCT02966184
Details
2021-05-20
Interventional
48 
Albuterol
Status Asthmati…
Study Drug Backorder
-
NCT02693717
Details
2021-05-20
Interventional
27 
Pemetrexed
Carcinoma Carcinoma, Tran… Metastatic Urot…
The trial was closed due to the changing efficacy of treatments for metastatic urothelial cancer.
This protocol was stopped early as it was considered unethical. A new protocol with the same study drugs plus an immune check point drug was added. There is no data to report.
NCT01131325
Details
2021-05-20
Interventional
43 
Nilotinib
Leukemia Leukemia, Myelo… Leukemia, Myelo… Philadelphia Ch… CML Chronic Myeloge… Philadelphia Ch…
-
The study was terminated early due to slow enrollment.
NCT01736579
Details
2021-05-19
Interventional
36 
Antibodies Immunoglobulins Immunoglobulins… Rho(D) Immune G… gamma-Globulins
Alzheimer Disea… Alzheimer´s Di…
The study was terminated because the first Phase 3 did not demonstrate efficacy on the co-primary endpoints. The known safety profile remained unchanged.
This study was an extension of study 160701 and was stopped early due to lack of evidence of clinical benefit of IGIV treatment in Alzheimer's Disease patients in Baxalta study 160701. Summary tables available for safety data only.
NCT00582205
Details
2021-05-19
Interventional
221 
Cisplatin Paclitaxel
Carcinoma Carcinoma, Ovar… Fallopian Tube … Ovarian Neoplas… Uterine Neoplas… Fallopian Tube … Ovarian Cancer Primary Periton… Uterine Cancer
Study completed per investigator.
-
NCT02514252
Details
2021-05-18
Interventional
26 
Fentanyl
Breakthrough Pa… Advanced Cancer…
-
-
NCT02055690
2013-005471-40
Details
2021-05-17
Interventional
1/221 
Fosbretabulin
Carcinoma, Ovar… Neoplasms Ovarian Neoplas… Neoplasms, Ovar… Ovarian Cancer
Safety
-
NCT02047539
Details
2021-05-17
Interventional
11 
Aspirin
Mental Disorder… Psychotic Disor… Clinical High R…
-
-
NCT04818736
Details
2021-05-14
Interventional
40 
Vaccines
Vaccine-Prevent… Vaccine Prevent…
Vaccine roll out plans increased so timing was no longer feasible
-
NCT00985621
2009-013329-41
Details
2021-05-14
Interventional
3614 
Oxycodone Tanezumab
Osteoarthritis
See termination reason in detailed description.
Due to the US FDA imposed clinical hold (effective 23 June 2010), study was terminated early and planned sample size was not reached. The primary time-point was changed from Week 16 to Week 8, as per change in planned analysis.
NCT03786419
Details
2021-05-13
Interventional
20 
Atezolizumab
Mesothelioma Mesothelioma, M… Malignant Pleur… Malignant Pleur…
Publication of study results of ICI use in MPM as first line therapy
-
NCT02722304
Details
2021-05-13
Interventional
37 
Alpha 1-Antitry… Protease Inhibi…
Alpha 1-Antitry… Lung Diseases Lung Diseases, … Pulmonary Disea… Alpha1-antitryp… Chronic Obstruc…
-
The Data Monitoring Committee (DMC) reviewed the available efficacy and safety data and unanimously recommended to terminate the study. The decision was based on the very low number of enrollees, and the slow rate of participant enrollment.
NCT02429934
Details
2021-05-13
Interventional
1/228 
Abatacept
Arthritis Lupus Erythemat… Systemic Lupus …
Response rate in placebo group for primary outcome was 100% on interim analysis.
-
NCT00994890
Details
2021-05-13
Interventional
2679 
Tanezumab
Osteoarthritis Osteoarthritis,… Osteoarthritis,…
See termination reason in detailed description.
Due to United States FDA imposed clinical hold, enrollment was stopped and study was terminated prematurely. Due to this, injection-site reaction data were not collected beyond Week 40 and NIS data were not collected beyond Week 48.
NCT04854044
Details
2021-05-12
Interventional
10 
TIC10 compound
Glioblastoma Gliosarcoma Recurrence Recurrent Gliob… Recurrent Glios… Recurrent Supra… Supratentorial …
The P.I. is not prepared to move forward at this thime
-
NCT04359511
Details
2021-05-12
Interventional
30 
Hydrocortisone Prednisone
COVID-19 Pneumonia
COMPETITOR TEST (RECOVERY)
-