Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03579888
Details
2021-06-02
Interventional
14 
Cyclophosphamid… Fludarabine
Leukemia Leukemia, Lymph… Leukemia, Lymph… Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Lymphoma, Mantl… Lymphoma, Non-H… Precursor Cell … Recurrence B Acute Lymphob… Recurrent B Acu… Recurrent Chron… Recurrent Diffu… Recurrent Mantl… Recurrent Non-H… Recurrent Ph-Li… Recurrent Prima… Recurrent Small… Refractory B Ac… Refractory Chro… Refractory Diff… Refractory Mant… Refractory Non-… Refractory Ph-L… Refractory Prim… Refractory Smal…
Study halted prematurely
-
NCT02768558
Details
2021-06-02
Interventional
320 
Etoposide Nivolumab
Carcinoma, Non-… Lung Neoplasms Non-Small Cell …
Another treatment found efficacious
This study was terminated early due to the reporting of another study which changed this population's standard of care and rendered the control arm obsolete. Eight of the planned 550 analyzable participants were enrolled at the time of termination.
NCT02065401
Details
2021-06-02
Interventional
10 
Magnesium Hydro…
Healthy
This study was withdrawn until the evaluation of the nonclinical rat findings is complete.
-
NCT01927913
2013-000743-33
Details
2021-06-02
Interventional
20 
Deferasirox
Hemosiderosis Iron Metabolism… Iron Overload Metabolic Disea… Thalassemia beta-Thalassemi… Beta-thalassemi… Iron Chelation Transfusional H… Transfusional I…
This study was withdrawn until the evaluation of the nonclinical rat findings is complete.
-
NCT04482712
Details
2021-06-01
Interventional
1/20 
Sirolimus
Acute Lung Inju… COVID-19 Lung Injury Respiratory Dis… Respiratory Dis… Respiratory Ins… Syndrome Acute Lung Inju… Respiratory Fai… Sars-CoV2
The study was never submitted to IRB or approved, due to feasibility issues
-
NCT04060407
Details
2021-06-01
Interventional
1/20 
Ipilimumab Nivolumab
Melanoma Metastatic Mela…
Business Reasons
-
NCT04483635
Details
2021-05-28
Interventional
334 
Cholecalciferol Vitamin D
COVID-19
A premature discontinuation was recommended by the Data Safety Monitoring Board and agreed upon by the principal investigator, because the significantly lower recruitment than planned, in the context of mass vaccination of the target population.
-
NCT04274166
Details
2021-05-28
Interventional
20 
Antibodies, Mon…
Pyoderma Pyoderma Gangre…
Contracting never completed, closed the IRB
-
NCT03347526
Details
2021-05-27
Interventional
3-
Cosyntropin Vigabatrin
Spasm Spasms, Infanti… Infantile Spasm
Study on enrollment hold as a precaution per the pharmaceutical company.
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NCT00945802
Details
2021-05-27
Interventional
35 
BB 1101 Ciprofloxacin Dexamethasone Dexamethasone a…
Otitis Otitis Externa Acute Otitis Ex…
-
-
NCT00945646
Details
2021-05-27
Interventional
36 
Dexamethasone
Otitis Otitis Externa Otomycosis Acute Fungal Ot…
-
-
NCT04530474
Details
2021-05-26
Interventional
30 
Ivermectin
COVID-19 Covid19
WHO report
-
NCT04373044
Details
2021-05-26
Interventional
26 
Hydroxychloroqu…
COVID-19 Laboratory Infe… Symptomatic COV…
The study was terminated after the release of results of ACTT-2 (NCT04401579).
-
NCT02820441
Details
2021-05-26
Interventional
42 
Zopiclone
Sleep Apnea Syn… Sleep Apnea, Ce… Ventricular Dys…
-
-
NCT00571519
Details
2021-05-26
Interventional
394 
Metformin Pioglitazone
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes…
DSPD focusing on Study 301 to confirm the clinical profile before proceeding. Daiichi Sankyo Pharma Development terminated this study on 23 Apr 2008 because of changes in the clinical development plan with 94 of 2600 planned, randomized participants.
-
NCT00542191
Details
2021-05-26
Interventional
230 
Carboplatin Cyclophosphamid… Doxorubicin Paclitaxel
Breast Neoplasm… Triple Negative… Breast Cancer
Enrollment Completed
-
NCT02927405
Details
2021-05-25
Interventional
40 
Gabapentin
Pain, Postopera… Postoperative P…
Did not get the study to take off, did not recruit any subjects, and then closed the study.
-
NCT02860117
Details
2021-05-25
Interventional
30 
Ketamine
Pain Pain, Burning
change in hospital policy
-
NCT01220128
2010-019909-42
Details
2021-05-25
Interventional
266 
Aromatase Inhib… Carboplatin Cyclophosphamid… Docetaxel Doxorubicin Epirubicin Fluorouracil Paclitaxel Trastuzumab
Breast Neoplasm… Neoplasms, Brea…
Study termination due to negative Ph III of another study product from same technology platform.
-
NCT01376700
2011-000410-18
Details
2021-05-24
Interventional
3
[1 Refs]
22 
Factor VIII
Hemophilia A
It became unlikely to achieve the study objective of 50% reduction over published inhibitor rates. The Data Monitoring Committee supported this decision.
Early termination lead to: -No statistical tests done on risk factors & inhibitor formation. -FVIII consumption by participant not calculated due to large variation in # of EDs. -FVIII-Specific Antibody Isotypes summary statistics not done.