Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

Filter:

Trial ID Phase Status Type
Results Reported Result Refs Exist Enrollment From To
Free Text
Annotations

7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03121963
Details
2021-06-22
Interventional
40 
Acetaminophen Acetaminophen, … Celecoxib Gabapentin Hydrocodone Oxycodone
Pain Management
This protocol was difficult to enroll into, and changes to personnel have made it difficult to main this study. Data collection was not completed and therefore, no data analysis was performed. The PI has made the decision to close this study.
-
NCT02323230
Details
2021-06-22
Interventional
24 
Cyclophosphamid…
Lymphoma Lymphoma, B-Cel… Lymphoma, Large… Diffuse Large B…
new study
-
NCT02128230
Details
2021-06-22
Interventional
220 
BB 1101 Cisplatin Cyclophosphamid… Dexamethasone Dexamethasone a… Doxorubicin Etoposide Etoposide phosp… Lenalidomide Lenograstim Liposomal doxor… Melphalan Thalidomide
Multiple Myelom… Neoplasms, Plas…
Low enrollment and Futility as determined by Amgen's Carfilzomib NASCR program.
The study was terminated early due to futility as determined by Amgen's Carfilzomib NASCR program in addition to low enrollment.
NCT01760993
2012-003920-18
Details
2021-06-22
Interventional
32 
Lisdexamfetamin…
Schizophrenia
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized.
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized
NCT01760889
2012-003919-57
Details
2021-06-22
Interventional
31 
Lisdexamfetamin…
Schizophrenia
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized
NCT01738698
2012-003918-14
Details
2021-06-22
Interventional
34 
Lisdexamfetamin…
Schizophrenia
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized.
Study was discontinued due to non-safety related business prioritization decisions. No subjects were randomized
NCT04530617
Details
2021-06-21
Interventional
2
[28 Refs]
246 
Camostat
COVID-19 Covid19 Diabetes Hypertension Obesity
Results from the interim analysis
-
NCT04613102
Details
2021-06-18
Interventional
2/30 
Cannabidiol
Epidermolysis B… Itch Pain
The study protocol should to be updated (major updates), following the second Health Canada review /requests. The study has been withdrawn form the REB review and will not be performed at SickKids.
-
NCT04234516
Details
2021-06-18
Interventional
40 
Buprenorphine Buprenorphine, … Morphine Naloxone
Opioid-Related … Substance-Relat… Suicidal Ideati… Opioid-use Diso…
PI leaving the institute
-
NCT04126343
2019-002797-31
Details
2021-06-18
Interventional
154 
Moxifloxacin Padsevonil
Healthy Study P…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures
-
NCT04039919
2019-000703-32
Details
2021-06-18
Interventional
140 
Padsevonil
Healthy Partici…
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures
The study was terminated because the decision was made to terminate the PSL development program in focal-onset seizures on 22 May 2020.
NCT03809650
Details
2021-06-18
Interventional
39 
Macitentan
Hypertension Hypertension, P… Chronic Thrombo…
Due to a change in the development strategy
-
NCT03547778
Details
2021-06-18
Interventional
40 
Misoprostol
Office Hysteros…
Unable to get patients interested in the study
-
NCT03528564
Details
2021-06-18
Interventional
24 
Epoetin Alfa Ferric Oxide, S…
Anemia Anemia, Iron-De… Chronic Disease Iron Deficienci… Joint Diseases Anemia of Chron… Anemia, Iron De… Hip Arthropathy Knee Arthropath…
The primary reasoning is that we were unable to demonstrate feasibility, prior to and because of the impact of COVID on our research programs.
-
NCT01823835
2014-004852-77
Details
2021-06-18
Interventional
1/2152 
Palbociclib
Breast Neoplasm… Breast Cancer
The Sponsor decided to halt the development of GDC-0810, but not due to any safety concerns.
-
NCT01562041
Details
2021-06-18
Interventional
214 
Ranolazine
Cardiovascular … Vascular Diseas… Atherosclerotic…
-
-
NCT04611776
Details
2021-06-16
Interventional
20 
Atezolizumab Carboplatin Gemcitabine Paclitaxel Pemetrexed
Carcinoma, Non-… Carcinoma, Non-…
The positive results from IMpower010 demonstrated benefit by adding atezolizumab as adjuvant therapy in early stage NSCLC. These results raised ethical concerns of enrolling pts to best supportive care over checkpoint inhibition in this setting.
-
NCT04579133
Details
2021-06-16
Interventional
2140 
Durvalumab Olaparib
Carcinoma Carcinoma, Tran… Urinary Bladder… Bladder Cancer Urothelial Carc…
Not approved
-
NCT03768726
Details
2021-06-16
Interventional
323 
Ziprasidone
Bipolar Disorde…
Pfizer has decided to perform the pre-specified final analysis at the current enrollment using a re-estimation of the sample size.
Prioritization of outcome measures per study team's discretion.
NCT02075047
Details
2021-06-16
Interventional
3171 
Ziprasidone
Bipolar Disorde…
Based on recent input from FDA, the pre-specified final analysis will be performed at the current enrollment using a re-estimation of the sample size.
-