Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT03639766
Details
2021-06-30
Interventional
43 
Botulinum Toxin… abobotulinumtox…
Raynaud Disease Raynaud Phenome…
Time and resource constraints
-
NCT03567616
2017-004232-11
Details
2021-06-30
Interventional
28 
Dexamethasone Pomalidomide Venetoclax
Multiple Myelom… Neoplasms, Plas…
Following results of the primary progression-free survival analysis from Study NCT02755597, company-sponsored MM studies were placed on partial clinical hold (PCH). Sponsor did not pursue release of the PCH for this study.
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NCT03285646
2017-001943-12
Details
2021-06-30
Interventional
363 
Fasinumab
Back Pain Low Back Pain Osteoarthritis Osteoarthritis,… Chronic Low Bac…
Due to implementation of an urgent safety measure, enrollment and dosing in R475-PN-1612 was stopped; enrolled participants entered the 20-week safety follow-up
Enrollment and study drug administration was stopped due to an urgent safety measure. As a result the small number of participants enrolled in this study limited the interpretability of the efficacy results.
NCT02631148
Details
2021-06-30
Interventional
212 
Melatonin
Prediabetic Sta… Obesity
International shortage of the chemical para-aminohippuric acid (PAH) due to manufacturing changes, led to inability to perform key measurements to meet trial objectives
-
NCT04943692
Details
2021-06-29
Interventional
3-
Metformin
Diabetes Mellit… Diabetes Mellit… Type 2 Diabetes
Administrative decision of the investigation direction
-
NCT04322396
Details
2021-06-29
Interventional
2117 
Azithromycin Hydroxychloroqu…
Communicable Di… Coronavirus Inf… Infections Virus Diseases Corona Virus In… Infection Viral
Recommended by the DSMB
Early termination based on recommendations from the DSMB leading to small numbers of subjects analyzed.
NCT01812759
Details
2021-06-29
Interventional
43 
Fentanyl Hydromorphone
Emergencies Pain
-
-
NCT00046163
Details
2021-06-29
Interventional
4-
Midodrine
Hypotension Hypotension, Or…
Study was terminated due to poor enrollment
-
NCT04762511
Details
2021-06-28
Interventional
117 
Vaccines
Herpes Simplex
To enable development of an enhanced version of the vaccine
-
NCT04534803
Details
2021-06-28
Interventional
30 
BCG Vaccine
COVID-19 Covid19
At this time it has been decided by the study team the the study will no longer take place in the United States.
-
NCT03032042
Details
2021-06-28
Interventional
40 
Albendazole Azithromycin
Helminthiasis Helminth Infect…
We were not able to secure IRB approval in the timeline necessary to do this study.
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NCT04131517
2019-002194-54
Details
2021-06-24
Interventional
114 
Ethinyl Estradi… Ethinyl estradi… Padsevonil
Healthy Female …
Based on available data, UCB has decided to stop development of padsevonil as adjunctive treatment of focal-onset seizures
The study was terminated on 22 May 2020 because the program developing padsevonil in focal-onset seizures was stopped.
NCT03577899
Details
2021-06-24
Interventional
31157 
Aflibercept
Macular Degener… Wet Macular Deg… Neovascular Age…
desired primary endpoint was not met
-
NCT01928446
Details
2021-06-24
Interventional
2/3519 
Lithium Carbona…
Bipolar Disorde… Depressive Diso… Mood Disorders Suicide Suicide, Attemp…
terminated early due to non-safety related DMC recommendations
-
NCT00809354
2008-004815-37
Details
2021-06-24
Interventional
32720 
Anti-Inflammato… Tanezumab
Osteoarthritis Osteoarthritis,… Arthritis
See termination reason in detailed description.
-
NCT00223938
Details
2021-06-24
Interventional
4112 
Ferric Compound… Ferric gluconat…
Anemia
The study was terminated because of significant enrollment challenges
-
NCT03630952
Details
2021-06-23
Interventional
31157 
Aflibercept
Macular Degener… Wet Macular Deg… Neovascular Age…
desired primary endpoint was not met
-
NCT04356677
Details
2021-06-22
Interventional
10 
Ribavirin
COVID-19 COVID19
Due to pandemic status changing in Canada prior to investigative sites being initiated for participation, and that concurrent participant recruitment in the global study BHC-RIB-5401-GL will achieve target enrollment across all countries.
-
NCT03219866
Details
2021-06-22
Interventional
440 
Budesonide Fluticasone-Sal… Ipratropium Tiotropium Brom…
Pulmonary Disea… COPD COPD Exacerbati…
Lower enrollment than Sponsor expected - Sponsor stopped study
-
NCT03190213
Details
2021-06-22
Interventional
26 
Pembrolizumab
Carcinoma, Neur… Neuroendocrine …
Update on clinical development: after discussions with the drug manufacturer, the PI has decided to discontinue the trial.
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