Friedrichs, M. (2023). A web-based annotation tool for clinical trial failure reasons. GMS Medizinische Informatik, Biometrie Und Epidemiologie, 19, Doc02. doi: 10.3205/mibe000241

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7805 Trials matched filter criteria

Status:   Withdrawn   Suspended   Terminated
Trial Updated /
Type
Status Phase Were
Results
Reported
Reported
Actual
Enrollment
(MeSH) Terms Why Stopped
Limitations And Caveats
Annotator decisions
NCT00451035
Details
2021-07-15
Interventional
2
[1 Refs]
29 
Panobinostat
Leukemia Leukemia, Myelo… Leukemia, Myelo… Chronic Myeloid…
-
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NCT00449761
Details
2021-07-15
Interventional
2
[1 Refs]
27 
Panobinostat
Blast Crisis Leukemia Leukemia, Myelo… Leukemia, Myelo… Leukemia, Myelo…
-
-
NCT00445068
Details
2021-07-14
Interventional
238 
Panobinostat
Multiple Myelom… Neoplasms, Plas…
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-
NCT03200600
Details
2021-07-13
Interventional
4126 
BB 1101 Dexamethasone Dexamethasone 2… Dexamethasone a… Flurbiprofen Flurbiprofen ax…
Carcinoma, Non-… Delirium Dexamethasone Flubiprofen Axe… Surgery--Compli…
Protocol violation occurred frequently during the postoperative period.
-
NCT03231397
Details
2021-07-09
Interventional
42 
Fluorodeoxygluc…
Aneurysm Aortic Aneurysm Aortic Aneurysm… Rupture Abdominal Aorti…
We were unable to recruit more subjects who met the inclusion/exclusion criteria and we have closed the study.
-
NCT01395953
Details
2021-07-09
Interventional
20 
Buspirone
Autism Spectrum… Autistic Disord… Child Developme… Autism Spectrum…
This study was withdrawn due to competing research interests and slow recruitment.
-
NCT00001962
Details
2021-07-09
Interventional
2100 
Daclizumab
Anemia Anemia, Aplasti… Anemia, Diamond… Red-Cell Aplasi… Aplastic Anemia Diamond Blackfa… Pure Red Cell A…
DSMB recommended closing the study and publishing the results
-
NCT04955262
Details
2021-07-08
Interventional
10 
Nivolumab
Melanoma Metastatic Mela…
Did not initiate due to business reasons. IND is inactive.
-
NCT03802227
Details
2021-07-08
Interventional
18 
Oxycodone
Chronic Pain Moderate to Sev…
Sponsor Decision
The study was originally planned for 24 patients. However enrollment was stopped due to the CDP being stopped at 8 and therefore limits the generalizability of this data.
NCT03040024
Details
2021-07-08
Interventional
471 
Ketamine
Delirium Otolaryngeal Ca…
Halted due to COVID 19; we believe we have adequate data for analysis
-
NCT02565511
2015-002715-15
Details
2021-07-08
Interventional
2/3480 
Umibecestat
Alzheimer Disea… Alzheimers Dise…
-
The study was terminated due to unexpected changes in cognitive function, brain volume loss, and body weight loss. Cohort II (CNP520) treatment was stopped and evaluated through an off-treatment follow-up period. After the decision to terminate Cohort II of the study (CNP520), treatment with CAD106 (Cohort I) was also terminated
NCT01784861
Details
2021-07-08
Interventional
1/223 
Everolimus
Neuroendocrine … Pancreatic Neop… Adenocarcinoma
Pharmaceutical company decision
-
NCT01070888
Details
2021-07-07
Interventional
46 
Budesonide Formoterol Fuma…
Asthma Asthma, Exercis… Exercise Induce…
Unable to reach target goal
-
NCT02440568
Details
2021-07-06
Interventional
1/222 
Cytarabine Homoharringtoni… Idarubicin
Acute Myeloid L…
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-
NCT04946162
Details
2021-07-02
Interventional
40 
Tadalafil
Pneumonia Respiratory Dis… ARDS, Human COVID Sars-CoV2
The investigators never completed the IRB application due to decrease in need to conduct the study.
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NCT01919190
Details
2021-07-02
Interventional
467 
Bupivacaine
Pain
Due to reasons unrelated to safety; primary endpoint signal seen during pre-specified interim analysis.
-
NCT03730402
Details
2021-07-01
Interventional
434 
Bupivacaine
Opioid Use
There were not enough attendings/residents working on the study throughout the COVID-19 pandemic in order to enroll the number of patients required to meet statistical significance.
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NCT03639779
Details
2021-07-01
Interventional
45 
Sodium thiosulf…
Calcinosis Calcinosis Cuti…
Time and resource constraints
The study had to be closed early due to lack up support/resources.
NCT04655183
Details
2021-06-30
Interventional
1/20 
Niraparib
Breast Neoplasm… Advanced Solid … Breast Cancer
Trial withdrawn based on portfolio prioritization; oral ATRi M1774 in combination with niraparib is under investigation in DDRiver Solid Tumor 301
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NCT03854396
Details
2021-06-30
Interventional
30 
Dehydroepiandro…
Communicable Di… Infections Recurrence Syndrome Urinary Tract I… Menopause Postmenopausal … Postmenopausal … Postmenopause Recurrent Urina…
due to termination of ISR by PI with agreement by grant sponsor
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